Serum prolactin levels in psoriasis and correlation with cutaneous disease activity

Abstract

These results indicate that serum PRL levels may serve as a biological marker of psoriatic disease activity.

Elevated serum prolactin levels as a marker of inflammatory arthritis in psoriasis vulgaris

“…22,31,32 ). More recent publications have demonstrated the positive correlation between PASI score and serum PRL levels in 20 and 23 patients with PV treated with tacalcitol 21 and propylthiouracil 33 , respectively, and the serum PRL levels were increased in both studies in PV patients compared to healthy individuals. However, two recent studies with 30 PV patients did not detect hyperprolactinemia or elevated PRL levels compared to healthy controls 34,35 and although PRL levels decreased after treatment of newly diagnosed PV, no correlation with PASI was found 35 .…”

“…30% of patients were treated by biologics. This is in contrast to Dilmé-Carreras 21 and Malligarjunan 33 as in these studies, systemic and topical treatment was unwarranted before enrollment. While PRL release can be influenced by chronic emotional stress 36 and PV is recognised as a disease with a psychological component, the small differences in treatment might have an impact on the perception of the disease and levels of psychological stress.…”

“…PRL is overexpressed in psoriatic skin lesions 20 . Dilmé-Carreras found a positive correlation between serum PRL levels and the corresponding index PASI (psoriasis area and severity index) after tacalcitol treatment 21 . Conversely, bromocriptine as a drug that downregulates PRL pituitary release was found to be effective in PsA treatment 22 .…”

Serum Prolactin and ImmunoglobulinE Levels in Psoriasis Vulgaris before and after NB-UVB Therapy

“…Indeed, these findings correspond well to an earlier study that had shown a positive association between raised serum PRL levels and psoriasis. An intriguing new dimension in the Dilme-Carreras et al [3] study was the finding that clinical improvement in psoriasis, in response to treatment with topical tacalcitol, was accompanied by a decrease in serum PRL level, and that there was a correlation between serum PRL level and clinical severity as assessed by PASI score. Comparing the results of this study with the results of the present study have showed increased serum prolactin level in the studied group of patients with plaque-type psoriasis vulgaris and decrease of this level after 3 months period of treatment with NB-UVB.…”

“…Dilme-Carreras et al [3] carried out a study on 20 patients with plaque-type psoriasis before and after a 6-weeks period of topical treatment. Results were compared with a group of 20 healthy volunteers.…”