Serum Prolidase Activity and Oxidative Status in Patients With Stage I Endometrial Cancer

Ariöz, Dağıstan Tolga; Camuzcuoğlu, Hakan; Toy, Harun; Kurt, Sefa; Çelik, Hakim; Aksoy, Nurten

doi:10.1111/igc.0b013e3181af711e

Cited by 39 publications

(28 citation statements)

References 21 publications

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“…Serum PEPD activity was found to be significantly higher in patients with endometrial cancer than in controls (40). PEPD activity was also shown to be significantly higher in human breast cancer tissues (41) and human lung cancer tissues (42) than in their corresponding control tissues.…”

Section: Discussionmentioning

confidence: 92%

Prolidase Directly Binds and Activates Epidermal Growth Factor Receptor and Stimulates Downstream Signaling

Yang

Ding

et al. 2013

Journal of Biological Chemistry

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Background: All known ligands of EGF receptor (EGFR) are characterized by the EGF motif and generated from transmembrane precursors. Results: Prolidase, a cytosolic dipeptidase devoid of EGF motif, binds and activates EGFR independent of its dipeptidase activity when present outside of cell. Conclusion: Prolidase is a novel EGFR ligand.Significance: This shows a new function of prolidase and new mechanism of EGFR activation.

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Section: Discussionmentioning

confidence: 92%

Prolidase Directly Binds and Activates Epidermal Growth Factor Receptor and Stimulates Downstream Signaling

Yang

Ding

et al. 2013

Journal of Biological Chemistry

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“…The final step of collagen degradation is catalyzed by intracellular prolidase; therefore, it may be associated with neoplastic transformation. Increased prolidase activities have been observed in some of cancers, such as lung cancer [15] , breast cancer [16] , endometrial cancer [17] , stomach cancer [18] , renal cell cancer [19] and ovarian cancer [20] . On the other hand, Palka et al [6] showed reduced levels of prolidase in pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

İlikhan¹,

Bilici²,

Şahin³

et al. 2015

WJG

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AIM:To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma (HCC). METHODS:Sixty-eight patients with HCC (mean age of 69.1 ± 10.1), 31 cirrhosis patients (mean age of 59.3 ± 6.3) and 33 healthy volunteers (mean age of 51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein (AFP) values with HCC clinicopathological features, such as tumor size, number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion (diameters; ≤ 3 cm, 3-5 cm Prospective Study ORIGINAL ARTICLEand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer (BCLC) criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at -80 ℃ until use. Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay. RESULTS:In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number, presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls (P < 0.001). Prolidase levels were significantly associated with tumor size and number (P < 0.001, P = 0.002, respectively). Prolidase levels also differed in patients in terms of BCLC staging classification (P < 0.001). Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis (P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately (P = 0.032, P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation (r = 0.616; P < 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification, whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels. CONCLUSION:Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. Core tip: Prolidase cleaves dipeptide bonds containing proline, playing a vital role in collagen turnover, matrix remodeling and cell growth. Neoplastic transformation results in deregulation of tissue collagen metabolism, in which metastatic tumor cells produce enhanced amounts of proteases to penetrate basement membranes and the extracellular matrix. Therefore, tumor progression might depend on the breakdown of collagen and other extracellular matrix proteins. The role of prolidase in neoplastic tissues is unknown. Herein, serum prolidase levels in hepatocellular carcinoma (HCC) patients were significantly associated with tumor size and number, Barcelona-clinic liver can...

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“…It is evident that the higher level of oxidants inside the body or cell may lead to serious consequences, several neurodegerative, parasitic diseases and cancer. [12][13][14]22,23] The imbalance between the levels of oxidants and antioxidants may implicate in the pathogenesis of SCCHN. The basic concept is that the free radicals damage cellular materials which could result in activation or altering normal cells into malignant ones.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the redox profile and oxidative DNA damage (8-OHdG) in squamous cell carcinoma of head and neck

Kumar¹,

Pant²,

Singh³

et al. 2012

J Can Res Ther

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Serum Prolidase Activity and Oxidative Status in Patients With Stage I Endometrial Cancer

Abstract: Increased serum prolidase activity and oxidative stress may be associated with endometrial cancer, and increased serum prolidase activity may be related to local invasion of endometrial cancer.

Cited by 39 publications

References 21 publications

Prolidase Directly Binds and Activates Epidermal Growth Factor Receptor and Stimulates Downstream Signaling

Prolidase Directly Binds and Activates Epidermal Growth Factor Receptor and Stimulates Downstream Signaling

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

Assessment of the redox profile and oxidative DNA damage (8-OHdG) in squamous cell carcinoma of head and neck

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