Serum Prostatic Acid Phosphatase, Gamma-Seminoprotein and Prostatic Specific Antigen in Hemodialysis Patients

Sasagawa, Isoji; Nakada, Teruhiro; Hashimoto, Tohru; Ishigooka, Manabu; Kubota, Yōko; Hirano, Kazuhiko; Hirano, Junji; Suzuki, Yukihiro

doi:10.1159/000282326

Cited by 24 publications

(9 citation statements)

References 6 publications

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“…We observed an elevation of mean postdialysis tPSA levels compared with predialysis values as Sasagava et al [5, 7], Kabalin and Hornberger [11]and Monath et al [12]also did, while Djavan et al [2]found a not significant postdialysis decrease of tPSA. Furthermore, we found a high correlation (p < 0.001) between postdialysis increases of tPSA and Hct.…”

Section: Discussionsupporting

confidence: 78%

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Prostate-Specific Antigen in Hemodialysis Patients and the Influence of Dialysis in Its Levels

Tzanakis¹,

Kazoulis²,

Girousis³

et al. 2002

Nephron

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The determination of prostate-specific antigen (PSA) is a useful tool in the diagnosis and follow-up of prostate cancer in males, but its diagnostic validity is uncertain in hemodialysis patients. We prospectively evaluated PSA in male hemodialysis patients as well as the influence of a single dialytic session on its levels. We measured pre- and postdialysis total PSA (tPSA) in 63 hemodialysis patients (mean age 68.44 ± 11.16 years, range 33–86 years) who had received dialysis with low flux membranes as well as in 729 normal subjects (mean age 63.22 ± 16.85 years, range 28–92 years). We also measured pre- and postdialysis hematocrit (Hct) in patients in order to estimate the degree of hemoconcentration after the dialysis session. If any of the examined patients or subjects had abnormal tPSA levels then free PSA (fPSA) and the f/tPSA ratio were additionally measured. Patients had lower levels of tPSA compared with those of the subjects (2.41 ± 4.06 vs. 3.76 ± 7.16 ng/ml, p < 0.05) while both of the two groups had near equal prevalence of individuals with abnormal values of tPSA or f/tPSA ratio (patients 12.69 and 7.93%, subjects 11.01 and 7.11%, respectively; nonsignificant. Dialysis resulted in a 9.48% increase in mean tPSA levels (2.41 ± 4.06 vs. 2.69 ± 4.06 ng/ml, nonsignificant) and in a 10.09% increase in mean Hct; the correlation between these increases was significant (r = 0.79, p < 0.001). In conclusion, our male hemodialysis patients had lower PSA levels compared with the general population, while both groups of individuals had a similar prevalence of abnormal values of tPSA and f/tPSA ratio. Dialysis with low flux membranes does not eliminate PSA and its postdialysis increase is due to hemoconcentration.

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Section: Discussionsupporting

confidence: 78%

“…The calculation of PSA levels, which has been applied in the general population as a marker of prostate cancer with relative success, has not been proven to be of the same value in the hemodialysis patients. Previous studies have not shown differences in PSA levels between hemodialysis male patients and the general population [7, 8, 9, 10]. …”

Section: Discussionmentioning

confidence: 97%

Prostate-Specific Antigen in Hemodialysis Patients and the Influence of Dialysis in Its Levels

Tzanakis¹,

Kazoulis²,

Girousis³

et al. 2002

Nephron

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“…In patients with chronic renal failure tumour markers are classified into three groups [lo]. The first group of markers includes alphafetoprotein, prostatic acid phosphatase, gamma seminoprotein, prostatic specific antigen and carbohydrate antigen 19-9, which show a low or non-existent increase in level [10,11]. In the second group comprising carbohydrate antigen 125 and neuron-specific enolase the levels are moderately elevated.…”

Section: Discussionmentioning

confidence: 99%

Serum level of immunosuppressive acidic protein in haemodialysis patients with or without renal cell carcinoma

Sasagawa

Nakada

Kubota

et al. 1994

British Journal of Urology

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“…No significant differences in serum PSA levels in men before and after HD have been reported [11][12][13][14] . PSA testing is considered to be a useful and accurate serum marker for the early detection of prostate cancer for men with ESRD who have been receiving long-term HD [15] .…”

Section: Discussionmentioning

confidence: 91%

Prostate Cancer Screening with Prostate-Specific Antigen in Hemodialysis Patients

Horinaga¹,

Kitamura

Saito

et al. 2007

Urol Int

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Background/Aims: The diagnostic validity of prostate-specific antigen (PSA) among men receiving hemodialysis (HD) has not been well defined. The aim of this study was to evaluate PSA levels in HD men and to compare them with those of non-uremic controls. Methods: PSA levels were measured in 620 HD men (40–89 years old, mean age 62.4 years). In patients with PSA >4.1 ng/ml, prostate biopsies were performed. Cancer-free men were defined as having PSA ranging between 0 and 4.0 ng/ml, or PSA >4.1 ng/ml but with a pathologically negative biopsy. The resulting data was compared with that for 3,636 non-uremic controls (55–59- (n = 468), 60–69- (n = 2,220), and 70–79-year-old men (n = 948)). Results: Of 45 HD men with PSA >4.1 ng/ml, 22 consented to undergo a biopsy. Ten were positive and 12 were negative. The mean PSA of cancer-free HD men of 50–59 (n = 159), 60–69 (n = 214), 70–79 (n = 116), and 80–89 (n = 30) were 1.0, 1.0, 1.3, and 2.1 ng/ml, respectively. Cancer-free HD men demonstrated significantly lower PSA compared to controls. Conclusions: HD men had lower PSA levels than those of controls.

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Serum Prostatic Acid Phosphatase, Gamma-Seminoprotein and Prostatic Specific Antigen in Hemodialysis Patients

Cited by 24 publications

References 6 publications

Prostate-Specific Antigen in Hemodialysis Patients and the Influence of Dialysis in Its Levels

Prostate-Specific Antigen in Hemodialysis Patients and the Influence of Dialysis in Its Levels

Serum level of immunosuppressive acidic protein in haemodialysis patients with or without renal cell carcinoma

Prostate Cancer Screening with Prostate-Specific Antigen in Hemodialysis Patients

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