Serum protein and immunoglobulin levels among nepalese living in southern Nepal

Abstract

Objective: This study examined the levels of serum protein fractionation, immunoglobulin (Ig) and antistreptolysin O (ASO) of people (91 males and 84 females aged 10-68 years) living in the Terai region of southern Nepal, as there had previously been no information available about them.Methods: Blood samples were collected early in the morning after overnight fasting. Serum protein fractionation was carried out by cellulose-acetate electrophoresis. IgG, IgA, IgM and ASO were measured by immuno-turbidimetry with clinical kits.Results: The mean proportion of albumin (Alb) was rather low due to increased globulin (Glb). The Alb level of males was significantly higher than that of females, while the male 1-Glb level was significantly lower than that of females. The mean values of IgG, IgM and ASO for males were lower than those values for females, although the difference was significant only for the IgM value. The mean values of IgM for female age groups of 30-39 years or less were significantly higher than those for the corresponding male age groups. Age correlated positively with IgA, and negatively with ASO in both sexes.

Human Gut Microbes Associated with Systolic Blood Pressure

“…Serum albumin and total protein levels were lower in the Nepali speakers relative to the Assamese population, but serum globulin level was lower in the Assamese. These findings are consistent with a previous study [ 36 ]. Higher serum albumin and total protein are biomarkers for poor nutritional status [ 41 ].…”

“…Few phenotypes and biochemical parameters, including BMI, blood albumin, globulin, and total protein, varied between locations. Albumin and total protein serve as markers of nutrition, while the higher concentration of globulin is indicative of higher pathogen load [ 36 , 37 ]. Furthermore, BMI was positively correlated with age (Spearman's rho = 0.486, P =1.708 e − 05) and it was significantly associated with clinical blood markers including globulin (Spearman's rho = 0.32, P =0.007), albumin (Spearman's rho = −0.686, P =3.744 e − 11), total protein (Spearman's rho = −0.74, P =1.639 e − 13), and triglyceride (Spearman's rho = −0.35, P =0.00249, Supplementary Figure 1 ).…”

“…Higher serum albumin and total protein are biomarkers for poor nutritional status [ 41 ]. On the other hand, higher globulin may indicate poor hygienic conditions [ 36 ]. These findings indicate that lifestyle guided by the Neo-Vaishnavite principles, which emphasizes pescatarian diet, good hygiene, and meditation, is reflected in the Satra's blood biochemistry.…”

Effects of Intake of Pickles Containing Lactobacillus brevis on Immune Activity and Bowel Symptoms in Female Students

“…In recent years, evidence has accumulated that dead bacterial cells can enhance immune activity in mammals, including humans (13,14,32,33). LAB, which live in a symbiotic relationship with humans in the intestines, recognize pathogenic bacteria, viruses, and food allergens as foreign and mediate bodily immune functions to eliminate them-i.e., the system by which intestinal bacteria, which naturally live symbiotically in host intestines, defend against pathogenic bacteria present in foods that are consumed.…”