Serum proteomic analysis revealed diagnostic value of hemoglobin for nonalcoholic fatty liver disease

Yu, Chaohui; Xu, Chengfu; Xu, Lei; Yu, Jian; Miao, Min; Li, Youming

doi:10.1016/j.jhep.2011.05.027

Cited by 87 publications

(87 citation statements)

References 37 publications

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“…These results are in agreement with previous epidemiologic studies that demonstrated that hemoglobin level is positively associated with risk of development of NAFLD independently of body mass index, type 2 DM, and other metabolic diseases [58]. Taken together, our results suggest reciprocal liver-bone cross-talk.…”

Section: Liver-bone Interactionssupporting

confidence: 93%

Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture

Fisher

2014

J Endocrinol Metab

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Section: Liver-bone Interactionssupporting

confidence: 93%

Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture

Fisher

2014

J Endocrinol Metab

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“…Type Ⅳ collagen is the main collagen component of basement membrane whereas laminin is the main non-collagenous glycoproand hs-CRP observed [40] . Serum haemoglobin levels have been observed to be significantly elevated in extremely obese NAFLD patient and shown to be significantly associated with prevalence of NAFLD [41][42][43] . Yu et al [42] performed a serum protein fingerprint analysis, utilising the SELDI-TOF-MS technique combined with bioinformatic approaches and discovered that haemoglobin subunit alpha was significantly up-regulated in NAFLD group.…”

Section: Extracellular Matrixmentioning

confidence: 99%

“…Serum haemoglobin levels have been observed to be significantly elevated in extremely obese NAFLD patient and shown to be significantly associated with prevalence of NAFLD [41][42][43] . Yu et al [42] performed a serum protein fingerprint analysis, utilising the SELDI-TOF-MS technique combined with bioinformatic approaches and discovered that haemoglobin subunit alpha was significantly up-regulated in NAFLD group. It has been proposed that the relationship between serum haemoglobin and NAFLD may be partially modulated by haptoglobin (Hpt), an α2-glycoprotein acute phase protein produced in response to an inflammatory insult [44] .…”

Section: Extracellular Matrixmentioning

confidence: 99%

“…Increased de novo lipogenesis might play a role in NAFLD pathogenesis [27] Uric Acid Sirota et al [33] 2013 Association of increased serum uric acid level and severity of NAFLD Mitochondrial oxidative damage could contribute to hepatic steatosis Acute phase protein hs-CRP Yoneda et al [39] 2007 Increased hs-CRP serum level in advanced NASH Acute phase proteins may have an immediate role in hepatocytes injuries predictive markers Serum levels of acute phase proteins do not necessary reflect the severity of disease NAFLD progression has a more complex underlying protein mechanism Haemoglobin Yu et al [42] 2012 Association of elevated serum haemoglobin levels and prevalence of NAFLD Fuc-Hpt Kamada et al [44] 2013…”

Section: Cps1mentioning

confidence: 99%

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Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis

Lim

Dillon

Miller

2014

WJG

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Non-alcoholic fatty liver disease (NAFLD) is a widely prevalent hepatic disorder that covers wide spectrum of liver pathology. NAFLD is strongly associated with liver inflammation, metabolic hyperlipidaemia and insulin resistance. Frequently, NAFLD has been considered as the hepatic manifestation of metabolic syndrome. The pathophysiology of NAFLD has not been fully elucidated. Some patients can remain in the stage of simple steatosis, which generally is a benign condition; whereas others can develop liver inflammation and progress into non-alcoholic steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. The mechanism behind the progression is still not fully understood. Much ongoing proteomic researches have focused on discovering the unbiased circulating biochemical markers to allow early detection and treatment of NAFLD. Comprehensive genomic studies have also begun to provide new insights into the gene polymorphism to understand patientdisease variations. Therefore, NAFLD is considered a complex and mutifactorial disease phenotype resulting from environmental exposures acting on a susceptible polygenic background. This paper reviewed the current status of proteomic and genomic studies that have contributed to the understanding of NAFLD pathogenesis. For proteomics section, this review highlighted functional proteins that involved in: (1) transportation; (2) metabolic pathway; (3) acute phase reaction; (4) antiinflammatory; (5) extracellular matrix; and (6) immune system. In the genomic studies, this review will discuss genes which involved in: (1) lipolysis; (2) adipokines; and (3) cytokines production. Key words: Non-alcoholic fatty liver disease; Proteomics; Genomics; Metabolic syndrome; Pathophysiology Core tip: Non-alcoholic fatty liver disease (NAFLD) is a widely prevalent hepatic disorder in Western populations. NAFLD can occur as a spectrum diseases, from simple steatosis, to non-alcoholic steatohepatitis characterised by hepatocellular injury and inflammation, to cirrhosis and hepatocellular carcinoma. This paper reviewed the current status of proteomic and genomic studies that have contributed to the understanding of NAFLD pathogenesis. This review highlighted several functional proteins and genetic polymoprhisms; particular those involved in insulin resistance, triglycerides metabolism and hepatic inflammation. It is hoped that this review will offer further insights into the pathophysiology of NAFLD.

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“…Proteomic methods were used to analyze 70 serum samples to identify potential new biomarkers for NAFLD. 29 The results suggested that serum hemoglobin was a biomarker, and this observation led to a prospective study to evaluate the predictive value of hemoglobin for NAFLD. The prospective study enrolled 6944 subjects who were followed up for 3 years 29 and showed that a higher baseline hemoglobin level was associated with a higher incidence of NAFLD.…”

Section: Hemoglobinmentioning

confidence: 99%

Non‐alcoholic fatty liver disease: Factors associated with its presence and onset

Miyake

Kumagi

Furukawa

et al. 2013

J of Gastro and Hepatol

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Non-alcoholic fatty liver disease (NAFLD) may progress to cirrhosis, liver failure, and complicated hepatocellular carcinoma. In addition, NAFLD is a risk factor for the development of other serious diseases, such as diabetes or cardiovascular disease. Therefore, the detection of early-stage NAFLD is important. Many studies have described the factors that predict the presence of NAFLD and its onset, and several markers have been identified. These markers have enabled the identification of high-risk patients and have improved routine medical practice. To prevent advanced disease, clinicians need to have simple markers that predict the onset of NAFLD so that interventions can be started at much earlier stages of disease. This review summarizes the current state of knowledge regarding independent factors, as reported in large studies, that predict the presence of NAFLD and its onset, especially markers that can be used in daily medical practice, such as physical measurements and blood tests.

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Serum proteomic analysis revealed diagnostic value of hemoglobin for nonalcoholic fatty liver disease

Cited by 87 publications

References 37 publications

Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture

Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture

Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis

Non‐alcoholic fatty liver disease: Factors associated with its presence and onset

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