Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension
Frane Pastrovic,
Rudjer Novak,
Ivica Grgurevic
et al.
Abstract:Introduction
Portal hypertension (PH) drives the progression of liver cirrhosis to decompensation and death. Hepatic venous pressure gradient (HVPG) measurement is the standard of PH quantification, and HVPG≥10 mmHg defines clinically significant PH (CSPH). We performed proteomics-based serum profiling to search for a proteomic signature of CSPH in patients with compensated advanced chronic liver disease (cACLD).
Materials and methods
Consecutive patients with histologically confirmed cACLD and results of HV… Show more
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