Serum pyridoxal concentrations and depressive symptoms among Japanese adults: results from a prospective study

Abstract

A higher vitamin B6 status may be associated with a decreased risk of depressive symptoms in Japanese.

Can Vitamin B6 help to prevent postpartum depression? A randomized controlled trial

“…[ 13 ] Nanri stated that a higher vitamin B6 level may be associated with a lower risk of depression symptoms in Japanese subjects. [ 30 ] Furthermore, a significant relationship was suggested between vitamin B6 with depressive symptomatology in Massachusetts elders. [ 14 ]…”

“…Based on the active role of pyridoxine phosphate in neurotransmitter synthesis, vitamin B6 may have a beneficial role in the prevention and treatment of depression. [ 30 ] A limited number of studies investigating the benefit of vitamin B6 supplementation focused on depression as part of premenstrual syndrome. [ 20 ] Low-dose oral contraceptive pills may adversely affect vitamin B6 levels and observed depression in plasma pyridoxal 5′-phosphate concentrations in oral contraceptive pill users may reflect decreased body reserves of vitamin B6.…”

A review of nutrient treatments for paediatric depression

“…Folic acid (vitamin B9) deficiency is associated with depressive symptoms (Gilbody et al, 2007) and supplementation has demonstrated antidepressant efficacy (Taylor et al, 2004). Deficiencies in vitamins B12 (Skarupski et al, 2010) and B6 (Merete et al, 2008;Nanri et al, 2013) have also been implicated in adult depression although well-controlled studies on their antidepressant effects following supplementation are limited with mixed findings (Williams et al, 2005a).…”