2021
DOI: 10.1186/s13018-021-02721-x
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Serum RANKL levels in Chinese patients with ankylosing spondylitis: a meta-analysis

Abstract: Objective We aimed to determine the association between serum receptor activator of nuclear factor-kappa B ligand (sRANKL) levels and ankylosing spondylitis (AS) in Chinese patients. Methods The PubMed, Cochrane Library, Embase, Chinese Biomedical Database, Web of Science, China National Knowledge Infrastructure, VIP, and Wan Fang databases were searched for studies conducted before October 1, 2020, without language restrictions. STATA version 12.0… Show more

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Cited by 4 publications
(3 citation statements)
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“…PTH is the main regulator of the RANK/RANKL/OPG system, which controls bone remodeling. RANKL levels have been shown to increase in AS patients compared to controls [ 30 ]. Between 18.7% and 62% of AS patients have osteoporosis, and 10% have a collapse fracture [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…PTH is the main regulator of the RANK/RANKL/OPG system, which controls bone remodeling. RANKL levels have been shown to increase in AS patients compared to controls [ 30 ]. Between 18.7% and 62% of AS patients have osteoporosis, and 10% have a collapse fracture [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, their results did not show any significant improvement in disease activity after the administration of symbiotics (28). Another probable player in AxSpA onset could be the receptor activator of nuclear factor-kappa B ligand (sRANKL); indeed, its serum level was found significantly increased in Chinese patients with AS, apparently in relation with functional compromission of patients and disease duration (29). It is well known that infections could act as a significant trigger in the onset of autoimmune diseases.…”
Section: Genetics and Pathogenesismentioning
confidence: 94%
“…• An imbalance in lymphocytes subsets seems to be involved in ax-SpA pathogenesis and the administration of symbiotics does not seem to correct it (26-28). • RANKL system could be related to AS onset (29). • A Klebsiella pneumoniae infection may have a role in AS development (30).…”
Section: Take-home Messagesmentioning
confidence: 99%