Serum RBP4 positively correlates with triglyceride level but not with BMI, fat mass and insulin resistance in healthy obese and non-obese individuals

Korek, Emilia; Gibas-Dorna, Magdalena; Chęcińska-Maciejewska, Zuzanna; Krauss, Hanna; Łagiedo‐Żelazowska, Małgorzata; Kołodziejczak, Barbara; Bogdański, Paweł

doi:10.1080/1354750x.2018.1479770

Cited by 20 publications

(16 citation statements)

References 30 publications

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“…In other studies, no such correlation has been found. In the Korek et al study, RBP4 levels did not correlate with BMI or fat mass and did not differ between individuals with obesity and those without obesity-RBP4 levels in both groups were 33.93 ± 4.46 and 32.53 ± 2.53 µg/mL, respectively [64]. Similar results were reported by other authors [65][66][67][68].…”

Section: Rbp4 Obesity and Metabolic Syndromesupporting

confidence: 78%

“…RPB4 levels are associated with dyslipidemia, which is a known risk factor for atherosclerosis. Strong, positive correlations between RBP4 levels and triglycerides, which constitute two major lipid abnormalities in both T2D and metabolic syndrome individuals, were observed in patients with and without obesity [64]. Higher RBP4 levels were correlated with higher levels of triglycerides and lower levels of high-density lipoprotein (HDL) cholesterol [66,76], as shown in Figure 3.…”

Section: Rbp4 and Lipid Metabolismmentioning

confidence: 87%

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Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?

Rychter

Skrzypczak-Zielińska

Zielińska

et al. 2020

IJMS

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Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity not only constitutes one of the main risk factors of CVD development but also alters adipokines. Increased attention is devoted to bioactive adipokines, which are also produced by the adipose tissue. The retinol-binding protein 4 (RBP4) has been associated with numerous CVDs and is presumably associated with an increased cardiovascular risk. With this in mind, exploring the role of RBP4, particularly among patients with obesity, could be a promising direction and could lead to better CVD prevention and management in this patient group. In our review, we summarized the current knowledge about RBP4 and its association with essential aspects of cardiovascular disease—lipid profile, intima-media thickness, atherosclerotic process, and diet. We also discussed the RBP4 gene polymorphisms essential from a cardiovascular perspective.

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Section: Rbp4 Obesity and Metabolic Syndromesupporting

confidence: 78%

Section: Rbp4 and Lipid Metabolismmentioning

confidence: 87%

Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?

Rychter

Skrzypczak-Zielińska

Zielińska

et al. 2020

IJMS

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“…Prior studies found an association between increased circulating Rbp levels and insulin resistance in various genetic and diet-induced models of obesity [ 41 , 42 ]. Human studies have been more controversial with variable relationships between Rbp concentrations and different cohorts with obesity, insulin resistance or type 2 diabetes [ [43] , [44] , [45] ], which could reflect dietary or genetic differences. DNA-arrays in the insulin-resistant adipose-specific glucose transporter type 4 (GLUT4) knockout mice revealed elevated Rbp expression levels in adipose tissue but unaltered Rbp expression in the liver [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis

Fenzl

Kulterer²,

Spirk³

et al. 2020

Molecular Metabolism

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Objective Transformation of white into brown fat (“browning”) reduces obesity in many preclinical models and holds great promise as a therapeutic concept in metabolic disease. Vitamin A metabolites (retinoids) have been linked to thermogenic programming of adipose tissue; however, the physiologic importance of systemic retinoid transport for adipose tissue browning and adaptive thermogenesis is unknown. Methods We performed cold exposure studies in mice and humans and used a genetic model of defective vitamin A transport, the retinol binding protein deficient (Rbp −/- ) mouse, to study the effects of cooling on systemic vitamin A and the relevance of intact retinoid transport on cold-induced adipose tissue browning. Results We show that cold stimulation in mice and humans leads to an increase in circulating retinol and its plasma transporter, Rbp. In Rbp −/- mice, thermogenic programming of adipocytes and oxidative mitochondrial function are dramatically impaired in subcutaneous white fat, which renders Rbp −/- mice more cold-sensitive. In contrast, retinol stimulation in primary human adipocytes promotes thermogenic gene expression and mitochondrial respiration. In humans, cold-mediated retinol increase is associated with a shift in oxidative substrate metabolism suggestive of higher lipid utilisation. Conclusions Systemic vitamin A levels are regulated by cold exposure in mice and humans, and intact retinoid transport is essential for cold-induced adipose tissue browning and adaptive thermogenesis.

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“…37 Korek et al did not observe in adult population significant correlation between RBP4 and anthropometric markers, such as body weight, BMI, WHR. 38 There are also contradictory studies which described that RBP4 correlated with age, anthropometric parameters and fat mass percentage. 15,24,39 Friebe et al observed that values of RBP4 were increasing with pubertal stage.…”

Section: Discussionmentioning

confidence: 99%

<p>Plasma RBP4 Level in Association with Body Composition, Metabolic Profile, STRA6 and RBP4 Gene Polymorphisms in Obese Romanian Children</p>

Boaghi

Pop

Vasilache

et al. 2020

DMSO

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Background: Pediatric obesity continues to remain a serious health concern which has significantly increased the morbidity risk in adulthood. Recent studies have analyzed the impact of the two adipokines, RBP4 (retinol binding protein 4) and STRA6 (stimulated by retinoic acid 6) in pediatric obese subjects with contradictory results. Methods: An observational study was conducted in the Pediatric and Endocrinology Departments, Targu-Mures, Romania, including 213 children between 5-17 years of age, divided into two groups according to body mass index (BMI) standard deviation score (SDS): case (overweight or obese) and control (normal SDS). Age, sex, basic anthropometric and biochemical measurements and genotype of rs3758539, and rs10882280 for RBP4 gene and rs974456 and rs351224 of STRA6 gene were analyzed. Statistical analysis used SPSS v. 25.0, with a level of significance α = 0.05. Results: There is no association between the two gene's polymorphisms and obesity in our pediatric population. In regression analysis, with HOMA IR (homeostatic model assessment of insulin resistance) as the outcome, the plasmatic level of RBP4 and fat mass percentage are significant predictors, with the model explaining 42% of the HOMA variability. Hypercholesterolemia was significantly associated with male sex, carrying variant allele and heterozygote status of rs10882280 RBP4 gene and wild-type allele rs351224 of STRA6 gene. Conclusion: There is no significant association between obesity and SNPs of the RBP4 and STRA6 in our population, but they seem to play a role in insulin resistance and hypercholesterolemia.

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Serum RBP4 positively correlates with triglyceride level but not with BMI, fat mass and insulin resistance in healthy obese and non-obese individuals

Abstract: Excessive adiposity without co-morbidities is not associated with higher levels of circulating RBP4. Serum RBP4 cannot be considered as a direct predictive marker for impaired glucose metabolism. RBP4 possibly contributes to lipid metabolism.

Cited by 20 publications

References 30 publications

Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?

Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?

Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis

<p>Plasma RBP4 Level in Association with Body Composition, Metabolic Profile, STRA6 and RBP4 Gene Polymorphisms in Obese Romanian Children</p>

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