Serum reproductive hormone levels and ultrasound findings in female offspring after intracytoplasmic sperm injection: first results

Body fat content, fat distribution and adipocytokine production and their correlation with fertility markers in young adult men and women conceived by intracytoplasmic sperm injection (ICSI)

“…The sample size was based on detecting differences in total sperm count, which was the primary outcome of the main project, that is reproductive health of young adults conceived by ICSI . In the present analysis of 56 ICSI and 53 control men and 70 ICSI and 80 control women, differences exceeding approximately 0.40 times the standard deviation in men, and 0.32 times the standard deviation in women are statistically significant with an alpha level of less than 5% (two‐sided test).…”

“…This study is part of a larger project on reproductive health in young ICSI adults. The recruitment procedure, inclusion and exclusion criteria, participation rates and results of the reproductive profile and metabolic profile of young ICSI adults have been reported elsewhere …”

“…Leptin levels were measured using the Human Leptin RIA test (EMD Millipore Corporation, USA) and adiponectin levels were measured with the Adiponectin ELISA kit (R&D Systems, USA). Serum AMH and inhibinB measurement techniques have been described previously …”

The safety of intracytoplasmic sperm injection and long-term outcomes

“…In addition, ICSI-conceived men were 3 times more likely to have sperm concentrations and 4 times more likely to have total sperm counts below the reference range of World Health Organization. A recent longitudinal study of 18-to 22-year-old women conceived via ICSI reported that these women had similar FSH, LH and AMH levels as naturally conceived women (Belva et al 2017b). The antral follicle counts were also comparable between the two groups.…”

Short‐ and long‐term outcomes in children born after assisted reproductive technology

“…The men conceived by ICSI were almost three times more likely to have sperm concentrations of <15 million/ml, and were four times more likely to have a total sperm count of <39 million . Antral follicle count and reproductive hormones in a cohort of 71 young adult women conceived by ICSI because of male factor infertility were similar to those reported for women who were spontaneously conceived …”