Serum resistin and adiponectin levels in young non-obese women with polycystic ovary syndrome

Arıkan, Şenay; Bahçeci, Mithat; Tuzcu, Alpaslan; Kale, Ebru; Gökalp, Deniz

doi:10.3109/09513590903247816

Cited by 36 publications

(23 citation statements)

References 43 publications

(44 reference statements)

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“…Several reports have described associations of adiponectin levels with indicators of IR [17][18][19] which were further supported by a meta-analysis published in 2009 [17]. We were unable to demonstrate any association between serum adiponectin levels and IR measured by the HOMA-IR in our population, similar to studies by Sarray et al and O'Connor et al [20] and the metaanalysis published by Li et al [21].…”

Section: Adiponectinsupporting

confidence: 89%

Altered leptin, adiponectin, resistin and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality

Baldani

Škrgatić

Kasum

et al. 2019

Gynecological Endocrinology

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The aim of the study was to investigate whether altered adipose tissue secretion of various adipokines is secondary to obesity, hyperandrogenism, and hyperinsulinemia or intrinsic to polycystic ovary syndrome (PCOS). This cross-sectional study included 151 women diagnosed with PCOS by the Rotterdam criteria and 95 healthy women matched by age, body mass index (BMI), and waist-to-hip ratio (WHR). Clinical, biochemical, and hormonal characteristics were assessed. Serum concentrations of ghrelin and adiponectin were found to be significantly lower and concentrations of leptin and resistin significantly higher in women with PCOS than in healthy women matched by age, BMI, and WHR. A PCOS diagnosis made the largest contribution to predicting serum levels of leptin, adiponectin, resistin, and ghrelin in all stepwise multiple regression models, which included PCOS diagnosis, BMI, WHR, luteinizing hormone, total testosterone, free testosterone and homeostatic model assessment of insulin resistance as independent predictors. Leptin, adiponectin, ghrelin and resistin levels may serve as independent biomarkers for the diagnosis of PCOS.

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Section: Adiponectinsupporting

confidence: 89%

Altered leptin, adiponectin, resistin and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality

Baldani

Škrgatić

Kasum

et al. 2019

Gynecological Endocrinology

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“…An additional 58 studies were excluded for the following reasons: 1) Less than 25 subjects with PCOS were included in 14 studies (2,49,54,57,67,69,78,82,107,118,121,135,141,147); 2) No controls were included in 28 studies (51,56,66,68,71,74,77,80,81,84–87,95,98,100,102,105,112,115,119,120, 123,126,139,143,148,152); 3) Patients and controls were also included in ulterior extended series by the same authors in 14 studies (7,35,58,92–94,101,110,113,116,125,131,149,150); 4) CRP concentrations were measured as a function of a polymorphism in the gene encoding the progesterone receptor, and not in PCOS and controls separately in 1 study (73); 5) It was unclear whether CRP was measured using a high sensitivity assay in 1 study, and there was no response from the corresponding author to a request for clarification (137). …”

Section: Resultsmentioning

confidence: 99%

Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis

Escobar-Morreale

Luque‐Ramírez

González

2011

Fertility and Sterility

430

296

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Objective-To review and meta-analyse the studies evaluating the status of serum inflammatory markers in women with Polycystic Ovary Syndrome (PCOS).Design-Systematic review and meta-analysis of articles published in English before January 2010 and identified using the Entrez-PubMed engine. Setting-Academic hospitalInterventions-Measurement of serum concentrations of inflammatory markers by highsensitivity techniques.Main Outcome Measures-Meta-analyses of the mean difference in serum C-reactive protein (CRP), interlekin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations among patients with PCOS and appropriate controls, applying random-effects models to limit interstudy variability, and using appropriate estimates of evidence dissemination bias.Results-Meta-analysis of the 31 articles meeting inclusion criteria showed that circulating CRP was 96% higher in women with PCOS compared to controls (95% confidence interval 71% -122%, z = 7.32, p < 0.0001) without evidence dissemination bias (Egger's regression intercept 0.45, 95% confidence interval −2.30 -3.21, P = 0.739). These findings persisted after excluding five studies with mismatches in body mass and/or frequency of obesity between women with PCOS and controls. Meta-analyses involving 10 studies of IL-6, and 9 studies of TNF-α revealed no statistically significant differences between PCOS and controls. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusion-Women with PCOS exhibit elevation in circulating CRP that is independent of obesity. This finding corroborates existing molecular evidence of the chronic low-grade inflammation that may underpin the pathogenesis of this disorder. NIH Public Access

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“…Data regarding adiponectin and resistin levels are rather conflicting in women with PCOS. These adipokines have been found either increased or conversely decreased, depending on the obesity status of the studied population [35, 36]. …”

Section: Muscle Insulin Resistance and Endocrine Diseasementioning

confidence: 99%

Skeletal Muscle Insulin Resistance in Endocrine Disease

Peppa

Koliaki

Nikolopoulos

et al. 2010

Journal of Biomedicine and Biotechnology

100

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We summarize the existing literature data concerning the involvement of skeletal muscle (SM) in whole body glucose homeostasis and the contribution of SM insulin resistance (IR) to the metabolic derangements observed in several endocrine disorders, including polycystic ovary syndrome (PCOS), adrenal disorders and thyroid function abnormalities. IR in PCOS is associated with a unique postbinding defect in insulin receptor signaling in general and in SM in particular, due to a complex interaction between genetic and environmental factors. Adrenal hormone excess is also associated with disrupted insulin action in peripheral tissues, such as SM. Furthermore, both hyper- and hypothyroidism are thought to be insulin resistant states, due to insulin receptor and postreceptor defects. Further studies are definitely needed in order to unravel the underlying pathogenetic mechanisms. In summary, the principal mechanisms involved in muscle IR in the endocrine diseases reviewed herein include abnormal phosphorylation of insulin signaling proteins, altered muscle fiber composition, reduced transcapillary insulin delivery, decreased glycogen synthesis, and impaired mitochondrial oxidative metabolism.

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Serum resistin and adiponectin levels in young non-obese women with polycystic ovary syndrome

Cited by 36 publications

References 43 publications

Altered leptin, adiponectin, resistin and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality

Altered leptin, adiponectin, resistin and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality

Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis

Skeletal Muscle Insulin Resistance in Endocrine Disease

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