Serum resistin levels in patients with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis

Abstract

The purpose of this meta-analysis was to investigate whether serum resistin level was associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) by comparing serum resistin levels between RA or SLE patients and normal controls. PubMed and EMBASE databases (up to May 13, 2014) were used to search all related articles. The weighted mean differences (WMDs) with 95 % confidence interval (CI) were calculated using random-effect model analysis. The Cochrane Q test and I(2) statistic were used to test heterogeneity. To assess publication bias, the Egger's test and visual observation of a funnel plot were used. The Newcastle-Ottawa scale was used to assess the study quality. The STATA statistical software (version 11.0) was applied to deal with statistical data. A total of eight studies of RA including 620 patients and 460 healthy controls, and six studies of SLE including 559 patients and 430 healthy controls were finally included in the meta-analysis. The results revealed that the serum resistin levels in RA were significantly higher than those in normal controls (WMD = 0.767 ng/ml, 95 % CI = 0.114-1.419, P = 0.021), but there was no significant difference between SLE patients and normal controls (WMD = 2.771 ng/ml, 95 % CI = -0.521-6.063, P = 0.099). Publication bias was undetected. In conclusion, this meta-analysis indicate that serum resistin level was significantly elevated in RA patients.

Adipokines in rheumatoid arthritis

“…Recently, Bustos Rivera-Bahena et al (2015) [24] demonstrated that resistin levels correlated positively with clinical manifestations of disease activity in patients with RA, albeit of patient body mass index. Huang et al (2015) [38] in a meta-analysis concluded that serum resistin levels were significantly higher in RA patients compared to control group. However, some authors did not show significant associations between serum resistin and HOMA-IR, nor differences between serum and synovial fluid resistin levels between RA patients and controls [19].…”

Machine learning applied to whole‐blood RNA‐sequencing data uncovers distinct subsets of patients with systemic lupus erythematosus

“…We identified several genes that were differentially expressed in patients with flare activity, including the RETN gene, encoding the proinflammatory adipokine resistin (Figure c). Interestingly, serum resistin levels were elevated in patients with rheumatoid arthritis and/or SLE, although the differences were reported not significant in unstratified patients with SLE, where high heterogeneity was noted . The specificity of elevated resistin levels to flare‐active patients may explain these results.…”

“…Interestingly, serum resistin levels were elevated in patients with rheumatoid arthritis and/or SLE, although the differences were reported not significant in unstratified patients with SLE, where high heterogeneity was noted. 44 The specificity of elevated resistin levels to flareactive patients may explain these results. However, longitudinal studies monitoring successive flares are needed to validate these observations, to identify new flare-predicting transcriptional signatures and to harness this information for better management of patients with SLE.…”

Association of single nucleotide polymorphisms in resistin gene with rheumatoid arthritis in a Chinese population

“…Nevertheless, results from these studies were inconsistent, and several studies had suggested that no significant difference was found in the serum expression level of resistin between RA patients and healthy controls . To further analyze serum resistin level in RA patients, a comprehensive meta‐analysis was performed and the result indicated that serum resistin level in RA patients was significantly elevated . In addition, the serum resistin levels were related to clinical disease activity, CRP and ESR in RA .…”