Serum resistin levels in patients with morbid obesity

Bobkova, Irina; Gussaova, S.S.; Stavrovskaya, E V; Bobrova, L.A.; Yashkov, Yu I; Бордан, Н С; Бекузаров, Д. К.; Evdoshenko, V. V.; Fedenko, V V; Malykhina, A. I.; Struve, Andrey V.

doi:10.32756/0869-5490-2019-4-24-29

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Показанное в нашем исследовании достоверное увеличение расчетной СКФ у пациентов с ожирением с исходной СКФ<90 мл/мин/1,73 м 2 на фоне значительного снижения массы тела после БО может быть прямым следствием потери массы тела, а также устранением неблагоприятного воздействия на почечную функцию ассоциированных с ожирением коморбидных состояний. К факторам положительного влияния снижения массы тела на СКФ также относится снижение нефротоксического действия жировой ткани, в частности за счет уменьшения выработки адипокинов [17]. Некоторое уменьшение СКФ у пациентов с исходно нормальной и повышенной фильтрацией может отражать снижение степени выраженности гломерулярной гиперфильтрации на уровне действующих нефронов у пациентов с длительным течением ожирения.…”

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Changes in metabolic parameters and glomerular filtration rate in patients with morbid obesity after bariatric surgery

Gussaova

Bobkova

Yashkov

et al. 2020

Terapevticheskii arkhiv

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Aim. To study the effect of weight loss in the short term after bariatric surgery (BO) on metabolic parameters and glomerular filtration rate (GFR) in patients with morbid obesity. Materials and methods. We studied 40 adult (over 18 years) patients with morbid obesity who underwent bariatric surgery. Metabolic indices and calculated GFR according to the CKD-EPI formula in patients before and after bariatric surgery were compared. Results. In the whole group of operated patients, the average body mass index (BMI) after surgery decreased from 45.8 to 30.5 kg/m2. In 11 (92%) patients with impaired carbohydrate metabolism, remission of diabetes mellitus was achieved and sugar-lowering drugs were canceled. In patients with baseline GFR90 ml/min/1.73 m2 after surgery, there is a tendency towards a decrease in GFR, probably due to a decrease in hyperfiltration. In patients with baseline GFR90 ml/min/1.73 m2 after surgery, a statistically significant increase in the level of GFR was noted. The greater metabolic efficacy of combined operations (mini-gastric bypass, biliopancreatic diversion) in relation to the correction of carbohydrate and fat metabolism was revealed. Conclusion. Obesity is a modifiable risk factor for decreased kidney function and the progression of chronic kidney disease. Bariatric surgery is an effective treatment for morbid obesity. The study proved the positive effect of weight loss after BO on renal function, including by improving the course of diseases associated with obesity.

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Changes in metabolic parameters and glomerular filtration rate in patients with morbid obesity after bariatric surgery

Gussaova

Bobkova

Yashkov

et al. 2020

Terapevticheskii arkhiv

View full text Add to dashboard Cite

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Cytokine profile and markers of fat metabolism in bronchial asthma patients with obesity and multimorbidity

Tribuntceva,

Budnevsky,

Prozorova

et al. 2023

Russian Family Doctor

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BACKGROUND: The number of people with multimorbidity has been steadily increasing in recent years. In patients with bronchial asthma, the level of control and cytokine profile with markers of fat metabolism may depend on body mass index and the presence of multimorbidity. AIM: To assess the relationships of disease control level, cytokine profile, adiponectins and oxidant stress level in asthma patients depending on body mass index and multimorbidity MATERIALS AND METHODS: Patients with asthma (n = 237) were divided into 3 groups depending on body mass index. We analyzed multimorbid pathology, assessed asthma control according to Asthma Control Questionnaire-5; determined interleukin-6, -4, resistin, tumor necrosis factor-alpha, degree of oxidative damage to biomolecules, antioxidant capacity of serum, leptin, adiponectin levels. Statistical analysis: Microsoft Excel, Statistica 12.0, Statgraphics XVIII. RESULTS: There were significantly more (p 0.05) comorbidities among the obese and asthma patients. The levels of leptin, resistin, interleukin-6, tumor necrosis factor-alpha, and degree of oxidative damage to biomolecules were significantly higher in the obese group. Direct correlations were found between body mass index, cumulative pathology rating scale, Asthma Control Questionnaire-5 and interleukin-6, tumor necrosis factor-alpha, degree of oxidative damage to biomolecules, leptin, and resistin control levels of asthma. An inverse correlation with adiponectin was detected with body mass index. CONCLUSIONS: Authentic increase of adipokins and anti-inflammatory cytokines, oxidative stress indexes and decrease of anti-inflammatory effects of adiponectin are noted in patients with asthma and obese patients. Multimorbidity further contributes to the development of systemic inflammation in patients with asthma. Obesity and multimorbidity are factors complicating the achievement of asthma control.

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Serum resistin levels in patients with morbid obesity

Cited by 2 publications

References 13 publications

Changes in metabolic parameters and glomerular filtration rate in patients with morbid obesity after bariatric surgery

Changes in metabolic parameters and glomerular filtration rate in patients with morbid obesity after bariatric surgery

Cytokine profile and markers of fat metabolism in bronchial asthma patients with obesity and multimorbidity

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