Serum Resistin Levels of Obese and Lean Children and Adolescents: Biochemical Analysis and Clinical Relevance

Gerber, Marisa; Boettner, Antje; Seidel, Bertolt; Lammert, Alexander; Bär, Jörg; Schuster, Ernst; Thiery, Joachim; Kieß, Wieland; Kratzsch, Jürgen

doi:10.1210/jc.2005-0437

Cited by 190 publications

(180 citation statements)

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“…Circulating resistin was reported to be elevated in human obesity in some, [3][4][5] but not in all studies. [6][7][8] Positive correlations of circulating resistin and insulin resistance 9,10 could not be confirmed in other studies. 7,11 These findings suggest that the role of resistin in the etiology of obesity and insulin resistance in humans -if there is any -is much more complex than in mice and other rodents.…”

Section: Introductionmentioning

confidence: 72%

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

et al. 2006

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Objective: Human resistin has been stated to influence preadipocyte cell numbers and to stimulate adipocyte triglyceride lipolysis in vivo and in vitro. However, its role in human obesity remains unclear. Design: Cross-sectional study for comparisons of lean and obese subjects, and subsequent longitudinal 4-month weight loss intervention study in obese subjects. Subjects: Healthy subjects, lean (n ¼ 20, BMIo25) and overweight (n ¼ 43, BMIX25). Measurements: Serum resistin, body weight, body fat, waist-to-hip ratio, as well as markers of insulin resistance and lipid metabolism at baseline and after 4 months of intervention. Results: Serum resistin was positively correlated to HOMA-IR (partial r ¼ 0.288; P ¼ 0.055), serum fructosamines (partial r ¼ 0.280; P ¼ 0.062), serum NEFA (partial r ¼ 0.276; P ¼ 0.066) and negatively to age (partial r ¼ À0.349; P ¼ 0.019) and serum apolipoprotein A-1 (partial r ¼ À0.363; P ¼ 0.014). During the intervention, serum resistin increased significantly (Po0.001). The increase was inversely related to changes in waist-to-hip ratio (P ¼ 0.025) and positively to serum apolipoprotein B (P ¼ 0.011). In males only, the increase in resistin during weight loss was predicted by total serum cholesterol at baseline (r ¼ 0.703, P ¼ 0.007). No relation was observed between changes in resistin and changes in HOMA-IR. Conclusion: The present study indicates an association between serum resistin and markers of abdominal fat distribution as well as the regulation of lipid metabolism. However, human resistin is unlikely to play an independent role in the regulation of glucose metabolism.

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Section: Introductionmentioning

confidence: 72%

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

et al. 2006

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“…2,3 The adipocyte-derived hormones resistin, adiponectin and leptin may play a role in the development of hypertension and/or insulin resistance. [4][5][6][7] Among children, inverse associations of adiponectin or resistin with body mass index (BMI) and insulin resistance have been reported, 8 but not all studies agree. 9 Studies on diet in childhood hypertension have mainly focused on sodium or calcium intake, rather than macronutrients.…”

Section: Hypertension Insulin Resistance Resistin and Adiponectinmentioning

confidence: 99%

“…4 Resistin promotes the release of endothelin-1, a potent vasoconstrictor, from endothelial cells, 20 although the resistin-like molecule-a has vasoconstrictive properties. 21 The relationship between resistin, adiponectin, adiposity and insulin resistance in humans is unclear; 22 several studies in adults have found resistin or adiponectin concentrations predict insulin resistance, 8,23 whereas others have not. 24 Several pediatric studies have not reported an association between resistin or adiponectin and weight status, leptin or insulin concentrations.…”

Section: Hypertension Insulin Resistance Resistin and Adiponectinmentioning

confidence: 99%

“…24 Several pediatric studies have not reported an association between resistin or adiponectin and weight status, leptin or insulin concentrations. 8,25,26 In adults, circulating leptin predictably rises after overfeeding 27 and falls after fasting. 28 However, whether specific macronutrients alter serum leptin concentrations independent of energy intake is equivocal.…”

Section: Hypertension Insulin Resistance Resistin and Adiponectinmentioning

confidence: 99%

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Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: a review

Zimmermann

Aeberli

2008

Int J Obes

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Objective: To review and summarize the dietary determinants of the metabolic syndrome, subclinical inflammation and dyslipidemia in overweight children. Design: Review of the current literature, focusing on pediatric studies. Participants: Normal weight, overweight, or obese children and adolescents. Results: There is a growing literature on the metabolic effects of excess body fat during childhood. However, few pediatric studies have examined the dietary determinants of obesity-related metabolic disturbances. From the available data, it appears that dietary factors are not only important environmental determinants of adiposity, but also may affect components of the metabolic syndrome and modulate the actions of adipokines. Dietary total fat and saturated fat are associated with insulin resistance and high blood pressure, as well as obesity-related inflammation. In contrast to studies in adults, resistin and adiponectin do not appear to be closely linked to insulin resistance or dyslipidemia in childhood. However, circulating leptin and retinol-binding protein (RBP) 4 correlate well with obesity, central obesity and the metabolic syndrome in children. Intakes of antioxidant vitamins tend to be low in obese children and may be predictors of subclinical inflammation. Higher fructose intake from sweets and sweetened drinks in overweight children has been linked to decreased low-density lipoprotein (LDL) particle size. Conclusions: Dietary interventions aimed at reducing intakes of total fat, saturated fat and free fructose, whereas increasing antioxidant vitamin intake may be beneficial in overweight children. More research on the relationships between dietary factors and the metabolic changes of pediatric obesity may help to identify the dietary changes to reduce health risks. International Journal of Obesity (2008) 32, S11-S18; doi:10. 1038/ijo.2008.202 Keywords: child; metabolic syndrome; diet; inflammation; adipokine IntroductionIn both industrialized and non-industrialized countries, the prevalence of pediatric obesity is increasing. 1 Dietary factors are environmental determinants of adiposity, as well as components of the metabolic syndrome, and may modulate the actions of adipokines. Better understanding of the relationships between dietary factors and the metabolic changes of pediatric obesity may help to identify the dietary changes to reduce health risks. Hypertension, insulin resistance, resistin and adiponectinPediatric obesity is an important risk factor for adult hypertension and type 2 diabetes, and approximately one third of obese children are hypertensive and/or hyperinsulinemic. 2,3 The adipocyte-derived hormones resistin, adiponectin and leptin may play a role in the development of hypertension and/or insulin resistance. 4-7 Among children, inverse associations of adiponectin or resistin with body mass index (BMI) and insulin resistance have been reported, 8 but not all studies agree. 9 Studies on diet in childhood hypertension have mainly focused on sodium or calcium intake, rather than macr...

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“…Human resistin has a tendency to form oligomers that are, in contrast to mice, biologically 6 more active [15,16,17]. However, both the oligomeric and dimeric forms of resistin are able to activate tumor necrosis factor (TNF)-α and interleukin (IL)-12 in macrophages and monocytes [18].…”

mentioning

confidence: 99%

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

375

297

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Serum Resistin Levels of Obese and Lean Children and Adolescents: Biochemical Analysis and Clinical Relevance

Cited by 190 publications

References 38 publications

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: a review

The role of resistin as a regulator of inflammation: Implications for various human pathologies

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