Serum retinol levels throughout 2 years of cholesterol-lowering therapy

Muggeo, Michele; Zenti, Maria Grazia; Travia, D.; Sartori, Angélica Rossi; Trimeloni, S.; Grigolini, L.; Graziani, Maria Stella; Cigolini, M.

doi:10.1016/0026-0495(95)90173-6

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Users of antihypertensive medicines had consistently higher plasma retinol concentrations at each plasma urea concentration, than non-users of these medicines. Some previous studies have reported relationships similar to those of the present study, between drugs use and vitamin status indices [23][24][25][26][27] . A study by Herbeth et al 26 found direct relationships between plasma retinol concentrations and the use of medicines by elderly European subjects, but the relation with renal function was not explored.…”

Section: Discussionsupporting

confidence: 87%

Use of medicines by older people in a large British national survey, and their relation to vitamin status indices

Bates

Walmsley

Prentice

et al. 1999

Public Health Nutr.

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Objective: To describe the extent of use of medicines by older people living in Britain, and to explore relationships with vitamin status indices. Design: The National Diet and Nutrition Survey of people aged 65 years and over collected data from a British sample during 1994-95. The present study has made novel use of it, to relate medicine use with biochemical indices of vitamin status. Setting: Eighty postcode areas, selected randomly from mainland Britain. Subjects: 1506 people, 65 years and over gave information about use of medication, and a 4-day weighed food record. Three-quarters gave blood for status indices. Results: 78% of those living in the community and 93% of those in institutions were using medication. Certain vitamin status indices: plasma retinol, erythrocyte folate and riboflavin, paradoxically suggested better status in users than in non-users of antihypertensive, gastrointestinal, central nervous system, corticosteroid or diabetic drugs. There was evidence of a link with renal insufficiency, especially for plasma retinol, but neither this nor increased nutrient intake, acute phase effects or haemoconcentration could explain the paradoxical associations. Conclusions: Caution is needed in interpreting certain vitamin status indices, especially in older people who are extensively using medicines. New vitamin indices are needed, to avoid confounding interferences.

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Section: Discussionsupporting

confidence: 87%

Use of medicines by older people in a large British national survey, and their relation to vitamin status indices

Bates

Walmsley

Prentice

et al. 1999

Public Health Nutr.

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“…In contrast, patients with less severe hypercholesterolemia had no difference in serum vitamin A compared with normocholesterolemic subjects. These results need to be compared with those of a recent study of 100 subjects [22], in which the authors showed that after 2 years on a low-fat diet and/or hypolipidemic drugs, no variation in serum vitamin A was found. The vitamin A deficiency in our patients could be due to the LDL apheresis rather than their hypercholesterolemic status.…”

Section: Discussionmentioning

confidence: 82%

Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

Lepage

Bonnefont‐Rousselot

Bruckert

et al. 1996

Cardiovasc Drug Ther

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Oxidation of low density lipoprotein is involved in the pathogenesis of atherosclerosis. Epidemiological studies suggest a negative correlation between the occurrence of cardiovascular diseases and blood concentrations of lipophilic antioxidants such as vitamins A and E and beta-carotene. Trace elements, such as selenium, zinc, and copper, are involved in the activity of the antioxidant enzymes glutathione peroxidase and superoxide dismutase. The aim of this study was to determine the antioxidant and trace element status of patients with severe hypercholesterolemia who had been treated with dextran-sulphate low-density lipoprotein apheresis in comparison with two control populations, normocholesterolemic subjects and untreated hypercholesterolemic patients. Our results showed that, patients treated with LDL apheresis, compared with normocholesteromic subjects, were not deficient in vitamin E, beta-carotene, and copper, but had lower plasma levels of selenium, zinc, and vitamin A. The low selenium and vitamin A levels were due to the LDL-apheresis treatment, and the hypercholesterolemia might have provoked the low plasma levels of zinc. The study pointed out the potential benefits of supplemental selenium, zinc, and vitamin A in patients being treated with LDL apheresis.

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“…Subsequently, the fall in circulating RBP 4 during the following 2 months resulted from the metabolic action of fenofi brate. Circulating RBP 4 decreases after combination treatment of diet and cholestyramine [ 93 ] . However, in this case, it can not be excluded that the diet caused the decrease in circulating RBP 4 , whereas the cholestyramine per se did not have any signifi cant impact on circulating RBP 4 .…”

Section: Rbp 4 Levels and Hypolipidemic Agents ( • ▶ Table 1 )mentioning

confidence: 99%

“…Statins cause a signifi cant reduction of circulating RBP 4 [ 93 ] or not change [ 31 ] or a nonsignifi cant trend for decrease [ 94 , 95 ] , which may be attributed either to the not long enough period of statin administration to induce changes in circulating RBP 4 [ 94 ] or to the relative low statin dose used [ 95 ] . The mechanism underlying the potential statin-induced reduction of circulating RBP 4 may involve the statin-LDL lowering eff ect, given the previously reported relationship between RBP 4 and LDL metabolism [ 64 , 67 ] .…”

Section: Rbp 4 Levels and Hypolipidemic Agents ( • ▶ Table 1 )mentioning

confidence: 99%

The Metabolic Role of Retinol Binding Protein 4: An Update

Christou

Tselepis²,

Kiortsis

2011

Horm Metab Res

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reviews investigating thoroughly all the metabolic eff ects of RBP 4. In this context, this article reviews the major aspects of the possible metabolic actions of RBP 4 and attempts to elucidate any resting confusion on this matter. The literature search was based on PubMed listings up to 1 August 2011. Type 2 Diabetes and Insulin Resistance ▼ Relationship between RBP 4 and clinical and laboratory parameters of insulin resistance Circulating RBP 4 and expression of RBP 4 mRNA in abdominal adipose tissue are increased in subjects with type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT), compared to subjects with normal glucose tolerance (NGT) [ 5-7 ]. However, circulating RBP 4 and synthesis rates of RBP 4 appear to be lower in type 1 diabetes mellitus (T1DM) compared to normal, nondiabetic individuals [ 8-11 ]. Furthermore, circulating RBP 4 is higher in women with gestational diabetes mellitus compared to healthy pregnant women [ 12 , 13 ]. Moreover, in nonobese, normoglycemic subjects with at least one fi rst-degree relative with T2DM, serum RBP 4 levels correlate inversely with the glucose disposal rate (GDR), which is a

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Serum retinol levels throughout 2 years of cholesterol-lowering therapy

Cited by 5 publications

References 33 publications

Use of medicines by older people in a large British national survey, and their relation to vitamin status indices

Use of medicines by older people in a large British national survey, and their relation to vitamin status indices

Antioxidant status of hypercholesterolemic patients treated with LDL apheresis

The Metabolic Role of Retinol Binding Protein 4: An Update

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