Serum S100A12 Levels Are Correlated with the Presence and Severity of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus

Zhao, Peng; Wu, Mingchun; Yu, Þ Houyou; Huang, Yang; Wang, Yutong; Wang, Wei; Yin, Wen

doi:10.2310/jim.0b013e318292fb1e

Cited by 32 publications

(21 citation statements)

References 23 publications

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“…Accumulating evidence has disclosed high levels of several inflammatory mediators including C-reactive protein, which are present at very high levels in the peripheral blood of patients at risk of POD or POCD (Cerejeira et al, 2012;Neerland et al, 2016;Vasunilashorn et al, 2017). It is confirmed initially that human S100A12 is expressed and secreted by activated neutrophil granulocytes (Achouiti et al, 2013;Bae et al, 2014;He et al, 2015;Isoyama et al, 2015Isoyama et al, , 2016Zhao et al, 2013). In this regard, S100A12 is known to trigger a pro-inflammatory immune response by binding RAGE, thereby leading to inflammatory activation (Achouiti et al, 2013;Bae et al, 2014;He et al, 2015;Isoyama et al, 2015Isoyama et al, , 2016Zhao et al, 2013).…”

Section: Discussionmentioning

confidence: 97%

Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients

et al. 2018

Brain and Behavior

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ObjectiveBrain injury is implicated in pathogenesis of postoperative delirium (POD) and cognitive dysfunction (POCD). S100A12 is involved in inflammatory process and is recently known as a biomarker for brain injury. Herein, we clarified whether serum S100A12 levels are related to POD and POCD after hip fracture surgery in elderly patients.Materials and MethodsIn this prospective, observational study, we gauged S100A12 levels in preoperative and postoperative serum from 186 patients and serum from 186 controls. Patients were categorized according to the presence of POD and POCD.ResultsPostoperative, but not preoperative serum S100A12 levels were significantly higher in patients than in controls. There was a positive and independent correlation between postoperative C‐reactive protein and S100A12 levels (t = 8.797, p < 0.001). Postoperative S10012 levels and age were independently associated with the risk of developing POD (S100A12 levels: odds ratio [OR] = 1.166, 95% confidence interval [CI] = 1.045–2.087, p = 0.001; age: OR = 1.243, 95% CI = 1.073–1.419, p = 0.012) and POCD (S100A12: OR = 1.157, 95% CI = 1.030–1.986, p = 0.003; age: OR = 1.228, 95% CI = 1.054–1.387, p = 0.014). In terms of area under receiver operating characteristic curve, postoperative S100A12 levels had a higher predictive ability than age and their combination dramatically exceeded that of each one alone.ConclusionsPostoperative elevated serum S100A12 levels have a strong relation to inflammation and are associated independently with the development of POD and POCD, substantializing serum S100A12 as a potential biomarker for predicting POD and POCD in elderly patients undergoing hip fracture surgery.

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Section: Discussionmentioning

confidence: 97%

Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients

et al. 2018

Brain and Behavior

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“…Previous studies reported that LY86 was involved in obesity, inflammation, and insulin resistance [31]. S100A8 and S100A12, belonging to the calgranulin gene family, play key immune response roles in inflammatory disorders, like diabetes and cardiovascular disease [32]. In addition, S100A8 can recruit macrophages to adipose tissue during inflammation and in the setting of hyperglycemia and obesity [33, 34].…”

Section: Discussionmentioning

confidence: 99%

Aberrant Expression of Long Non-Coding RNAs in Newly Diagnosed Type 2 Diabetes Indicates Potential Roles in Chronic Inflammation and Insulin Resistance

Wang

Zhang

et al. 2017

Cell Physiol Biochem

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Background/Aims: Long non-coding RNAs (lncRNAs) have emerged as key players in several biological processes and complex diseases. The risk of type 2 diabetes (T2D) is determined by a combination of environmental factors and genetic susceptibility. The purpose of this study was to identify aberrant lncRNAs involved in T2D pathogenesis. Methods: Microarray analysis was performed using whole blood samples from patients newly diagnosed with T2D and healthy controls. Pathway and Gene Ontology (GO) analyses were utilized to annotate the target genes. Coding non-coding co-expression (CNC) analysis was performed to construct a co-expression network. Results: We found 55 lncRNAs and 202 mRNAs were differentially expressed in the T2D group compared to the healthy control group. Pathway and GO analyses demonstrated that dysregulated mRNAs were mainly associated with immune regulation, inflammation, and insulin resistance, whereas CNC analysis identified 10 pairs of co-expressed lncRNA-mRNAs in our patient cohort (R > 0.99). Furthermore, expression of the top three upregulated lncRNAs in the T2D group was correlated with measures of glycometabolism (P < 0.05). Conclusion: This study identified aberrantly expressed lncRNAs and mRNAs in Han Chinese patients with T2D, and demonstrated that dysregulated lncRNAs may have roles in T2D pathogenesis through regulation of inflammation and insulin resistance.

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“…[12][13][14][15][16] The design of the mentioned studies is mainly cross-sectional and conducted in patient populations. A positive association between EN-RAGE and CHD mortality was shown in a prospective study, including patients on hemodialysis.…”

Section: Discussionmentioning

confidence: 99%

En-Rage

Ligthart

Sedaghat

Ikram

et al. 2014

ATVB

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Objective-Inflammation plays a key role in atherosclerosis. We hypothesized that novel inflammatory markers may predict the risk of coronary heart disease (CHD). Approach and Results-We investigated the association of 16 inflammatory biomarkers with the risk of CHD in a random subset of 839 CHD-free individuals in a prospective population-based cohort study. A Bonferroni corrected P value of 3.1×10 −3 was used as a threshold of statistical significance. The mean age at baseline was 72.8 years. During a median follow-up of 10.6 years, 99 cases of incident CHD were observed. Among all inflammatory biomarkers, neutrophilderived human s100a12 (extracellular newly identified receptor for advanced glycation end-products binding protein [EN-RAGE]) showed the strongest association with the risk of CHD (P value 2.0×10 −3 ). After multivariable adjustment for established cardiovascular risk factors, each standard deviation increase in the natural log-transformed EN-RAGE was associated with 30% higher risk of incident CHD (hazard ratio, 1.30; 95% confidence interval, 1.06-1.59). Further adjustment for previously studied inflammatory markers did not attenuate the association. Excluding individuals with prevalent type 2 diabetes mellitus, impaired kidney function, or individuals using antihypertensive medication did not change the effect estimates. Cause-specific hazard ratios suggested a stronger association between EN-RAGE and CHD mortality compared with stable CHD. Additional adjustment for previously studied inflammatory markers yielded slightly increased effect estimates (Table 2; Table IV in the online-only Data Supplement). Cumulative incidence curves for the tertiles of EN-RAGE adjusted for competing risks are depicted in Figure 2. The 10-year probability of first incident event of CHD was 0.05 (95% CI, 0.03-0.08) for the first tertile, 0.11 (95% CI, 0.07-0.14) for the second tertile, and 0.14 (95% CI, 0.10-0.18) for the third tertile. Conclusions-Our results highlight EN-RAGE as an inflammatoryAfter excluding participants with chronic kidney disease at baseline, the association between EN-RAGE and incident CHD attenuated slightly (1.28; 95% CI, 1.03-1.59; Table 3). Excluding participants with type 2 diabetes mellitus, the effect estimates of the association between EN-RAGE and CHD did not change: hazard ratio 1.29 (95% CI, 1.04-1.60) in the fully adjusted model. Finally, after excluding participants taking antihypertensive medication, the hazard ratio did not change (HR, 1.40; 95% CI, 1.05-1.87). ). DiscussionIn this prospective, population-based cohort study, we found that higher EN-RAGE levels were associated with an increased risk of CHD beyond conventional risk factors. Further adjustments for inflammatory markers, as well as excluding diseased individuals, did not change the results. These findings suggest proinflammatory EN-RAGE as a new inflammatory risk marker for CHD that represents a distinct inflammatory pathway compared with other inflammatory markers.Previous studies have observed increased levels of E...

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Serum S100A12 Levels Are Correlated with the Presence and Severity of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus

Abstract: High S100A12 levels are associated with the presence and severity of CAD in patients with T2DM.

Cited by 32 publications

References 23 publications

Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients

Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients

Aberrant Expression of Long Non-Coding RNAs in Newly Diagnosed Type 2 Diabetes Indicates Potential Roles in Chronic Inflammation and Insulin Resistance

En-Rage

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