Serum S100A12 May Be a Useful Biomarker of Disease Activity in Adult-onset Still’s Disease

Bae, Chang-Bum; Suh, Chang‐Hee; An, Jie; Jung, Ju‐Yang; Jeon, Jun Young; Nam, Jin-Young; Kim, Hyoun‐Ah

doi:10.3899/jrheum.140651

Cited by 44 publications

(26 citation statements)

References 38 publications

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“…Thus far, many studies have shown correlations between serum S100A12 and the prognoses of some inflammatory diseases, as well as between serum S100A12 and the activity of these diseases. 20,21 The findings of the present study suggest that S100A12 levels are correlated with the prognosis and severity of DM-ILD.…”

Section: Discussionsupporting

confidence: 51%

Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis-associated interstitial lung disease

et al. 2019

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Objective: S100A12 is an emerging inflammatory disease biomarker. Interstitial lung disease (ILD) is a common, severe complication of dermatomyositis (DM). This study was performed to investigate the association between S100A12 and disease activity and prognosis in patients with DM-associated ILD (i.e., DM-ILD). Methods: Serum S100A12 levels were measured using enzyme-linked immunosorbent assays in patients with stable DM-ILD, patients with acute exacerbation of DM-ILD (AE DM-ILD), and healthy controls (HCs). The relationships of serum S100A12 levels with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ferritin, high-resolution computed tomography (HRCT) scores, and pulmonary functions were evaluated by multiple unpaired t-tests and Pearson correlation. Results: Serum S100A12 levels were higher in patients with stable DM-ILD and those with AE DM-ILD than in HCs. Serum S100A12 levels in patients with stable DM-ILD and those with AE DM-ILD were positively correlated with CRP, ESR, and ferritin. S100A12 levels were positively correlated with HRCT scores in patients with stable DM-ILD and those with AE DM-ILD, while they were negatively correlated with predicted percentages of forced vital capacity and predicted percentages of carbon monoxide diffusing capacity in those patients. Conclusion: Our findings demonstrate the usefulness of serum S100A12 levels for assessing clinical severity and prognosis of DM-ILD.

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Section: Discussionsupporting

confidence: 51%

Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis-associated interstitial lung disease

et al. 2019

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“…Later on, such results were confirmed and a positive correlation of S100A8/A9 with leukocyte count, ESR, CRP, ferritin, systemic disease score and also a decrease after disease activity status resolution were detected [85]. More recently, a correlation with disease activity, serological markers (ESR, CRP, ferritin) and systemic score was described for the S100A12 protein too [86].…”

Section: S100a8 A9 A12mentioning

confidence: 82%

“…[60] S100A8/A9 11,770 ± 8840 ng/ml 36 [85] 57.11 ± 25.38 ng/ml 25 [84] 0.5-9 ng/ml 18 [35] S100A12 547.9 ± 148.4 ng/ml 37 [86] Procalcitonin 0.09-71 ng/ml 5 [70] 2-10 ng/ml 1 [72] 0-1.4 ng/ml 38 [73] SD: Standard deviations.…”

Section: Biomarkersmentioning

confidence: 99%

Presentation and diagnosis of adult-onset Still’s disease: the implications of current and emerging markers in overcoming the diagnostic challenge

Colafrancesco¹,

Priori²,

Valesini³

2015

Expert Review of Clinical Immunology

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Adult-onset Still's disease (AOSD) is a known cause of fever of unknown origin. It is characterized by a triad of symptoms: spiking fever (>39°C), salmon-colored rash and arthritis/arthralgia. On a predisposing genetic background, several conditions may act as trigger for disease and among these, infectious agents are the most important. Nowadays, a dichotomous view of AOSD has been introduced which distinguishes this entity in two subsets according to the clinical features and laboratory aspects: systemic or articular. As AOSD is a diagnosis of exclusion, specific biomarkers able to facilitate differential diagnosis are needed. A number of possible biomarkers have been proposed that will be discussed in detail in this review: ferritin, IL-18, procalcitonin, s100 proteins and sCD163.

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“…Accumulating evidence has disclosed high levels of several inflammatory mediators including C-reactive protein, which are present at very high levels in the peripheral blood of patients at risk of POD or POCD (Cerejeira et al, 2012;Neerland et al, 2016;Vasunilashorn et al, 2017). It is confirmed initially that human S100A12 is expressed and secreted by activated neutrophil granulocytes (Achouiti et al, 2013;Bae et al, 2014;He et al, 2015;Isoyama et al, 2015Isoyama et al, , 2016Zhao et al, 2013). In this regard, S100A12 is known to trigger a pro-inflammatory immune response by binding RAGE, thereby leading to inflammatory activation (Achouiti et al, 2013;Bae et al, 2014;He et al, 2015;Isoyama et al, 2015Isoyama et al, , 2016Zhao et al, 2013).…”

Section: Discussionmentioning

confidence: 97%

Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients

et al. 2018

Brain and Behavior

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ObjectiveBrain injury is implicated in pathogenesis of postoperative delirium (POD) and cognitive dysfunction (POCD). S100A12 is involved in inflammatory process and is recently known as a biomarker for brain injury. Herein, we clarified whether serum S100A12 levels are related to POD and POCD after hip fracture surgery in elderly patients.Materials and MethodsIn this prospective, observational study, we gauged S100A12 levels in preoperative and postoperative serum from 186 patients and serum from 186 controls. Patients were categorized according to the presence of POD and POCD.ResultsPostoperative, but not preoperative serum S100A12 levels were significantly higher in patients than in controls. There was a positive and independent correlation between postoperative C‐reactive protein and S100A12 levels (t = 8.797, p < 0.001). Postoperative S10012 levels and age were independently associated with the risk of developing POD (S100A12 levels: odds ratio [OR] = 1.166, 95% confidence interval [CI] = 1.045–2.087, p = 0.001; age: OR = 1.243, 95% CI = 1.073–1.419, p = 0.012) and POCD (S100A12: OR = 1.157, 95% CI = 1.030–1.986, p = 0.003; age: OR = 1.228, 95% CI = 1.054–1.387, p = 0.014). In terms of area under receiver operating characteristic curve, postoperative S100A12 levels had a higher predictive ability than age and their combination dramatically exceeded that of each one alone.ConclusionsPostoperative elevated serum S100A12 levels have a strong relation to inflammation and are associated independently with the development of POD and POCD, substantializing serum S100A12 as a potential biomarker for predicting POD and POCD in elderly patients undergoing hip fracture surgery.

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Serum S100A12 May Be a Useful Biomarker of Disease Activity in Adult-onset Still’s Disease

Cited by 44 publications

References 38 publications

Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis-associated interstitial lung disease

Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis-associated interstitial lung disease

Presentation and diagnosis of adult-onset Still’s disease: the implications of current and emerging markers in overcoming the diagnostic challenge

Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients

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