Serum S100B but not NSE Levels are Increased in Morbidly Obese Individuals Affected by Obstructive Sleep Apnea–Hypopnea Syndrome

Silva, Leandro Giacometti da; Mottin, Cláudio Corá; Souza, Diogo O.; Portela, Luis Valmor; Braga, Carla Winei; Vargas, Carolina Boeira; Padoin, Alexandre Vontobel; Martinez, Dênis; Dias, Renato Dutra

doi:10.1007/s11695-007-9386-6

Cited by 14 publications

(15 citation statements)

References 28 publications

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“…30 These different results could be explained by the ethnic difference, medications, cerebral areas affected or characteristics of population. 5 In conclusion, in our study, S100B protein level in serum did not significantly higher in patients with OSAS compared to the control group. However, further investigations are required, particularly in the area of biochemical markers of small cerebral damage in patients with OSAS, to monitor progression and efficacy.…”

Section: Discussioncontrasting

confidence: 39%

“…4 The severity of OSAS is measured by apnea hypopnea index (AHI), which is classified three levels: mild (AHI=5 to 15 events per hour); moderate (AHI=15 to 30 events per hour); and severe (AHI=>30 events per hour). 5 The repetitive hypoxia and reoxygenation cycle in OSAS is thought to resemble ischemia-reperfusion injury. 6 The central neural system(CNS) is vulnerable to these hypoxic condition and neurocognitive manifestation of OSAS, which includes daytime sleepiness alteration in personality, impairment in concantretations, perception, communication, learning and memory .…”

Section: Introductionmentioning

confidence: 99%

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Serum S100B levels in patients with obstructive sleep apnea syndrome

Öztürk

Giniş²,

Arlı³

et al. 2012

J Clin Exp Invest

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Section: Discussioncontrasting

confidence: 39%

Section: Introductionmentioning

confidence: 99%

Serum S100B levels in patients with obstructive sleep apnea syndrome

Öztürk

Giniş²,

Arlı³

et al. 2012

J Clin Exp Invest

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“…Da Silva et al reviewed the effects of OSA on homeostasis in the central nervous system (CNS) by examining the levels of biochemical markers of cerebral injury (neuron-specific enolase and the S100B protein derived from astrocytes) in OSA patients. The results of their study showed a significant increase in S100B markers, suggesting a CNS astrocyte reaction in response to cerebral hypoxemia in patients with OSA and supporting the view that OSA causes brain alterations, which can manifest as neuropsychological symptoms [20].…”

Section: Sa and Oxidative Stressmentioning

confidence: 61%

Sleep Apnea in Traumatic Brain Injury: Understanding Its Impact on Executive Function

Mollayeva

Kendzerska²,

Mollayeva³

et al. 2013

J Sleep Disord Ther

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Background: Persons who have sustained a traumatic brain injury are at a significantly increased risk for sleep disorders. One of the most commonly diagnosed sleep disorders after traumatic brain injury is sleep apnea, defined as a cessation of breathing accompanied by frequent arousals and hypoxia during sleep. The effects of untreated sleep apnea on a person's cognitive decline and the development of behavioral deficits have only recently been identified. It has been shown that axonal damage can occur because of sleep apnea and numerous neuropsychological studies of sleep apnea patients show deficits in cognitive domains, such as executive function and attention. However, there has been little published discussion regarding the interaction between sleep apnea and executive function among persons with traumatic brain injury. Objectives: The objectives of this review were to 1) review/synthesize published work relevant to the discussion of sleep apnea influencing executive function; and 2) clarify the nature of the interface between executive function and sleep apnea in persons with traumatic brain injury. Results: Until now, little attention has been directed to the neurobehavioral consequences of sleep apnea in persons with traumatic brain injury. There is an urgent need for more longitudinal research examining the effects of sleep apnea on executive function after traumatic brain injury and the effectiveness of sleep apnea treatment on executive function after injury.

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“…The studies were published from 2002 to 2017. Two studies were reported in Germany [10,21], two in Brazil [15,17], one in the Czech Republic [16], three in Turkey [18][19][20], and one in Egypt [22]. Three were crosssectional studies [10,16,17], and six were casecontrol studies [15,[18][19][20][21][22].…”

Section: Resultsmentioning

confidence: 99%

The effect of obstructive sleep apnea syndrome on serum S100B and NSE levels: a systematic review and meta-analysis of observational studies

et al. 2020

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Background: Obstructive sleep apnea syndrome (OSAS) is a common disorder that is accompanied by structural brain changes. This meta-analysis aimed to evaluate the effect of OSAS on the serum levels of astrocytic protein (S100B) and neuron-specific enolase (NSE) in observational studies. Methods: A comprehensive search was performed in the PubMed/Medline, Web of Science, Scopus, ScienceDirect, and Cochrane Library databases to assess the serum level of S100B and/or NSE in patients with OSAS and/or controls. The quality of the study was evaluated by the Newcastle-Ottawa Scale (NOS). A random-effects model was performed using RevMan 5.3 with the mean difference (MD) and 95% confidence intervals (CIs). Results: Out of 63 studies found in the mentioned databases and one identified by a manual search, nine studies were included and analyzed in this meta-analysis (three cross-sectional and six case-control studies). The analysis showed that the S100B [MD = 53.58 pg/ml, 95%CI: 1.81, 105.35; P = 0.04] and NSE levels [MD = 3.78 ng/ml, 95%CI: 2.07, 5.48; P < 0.0001] were significantly higher in patients than the controls. However, there were no significant differences between the S100B [MD =-28.00 pg/ml, 95%CI: − 79.48, 23.47; P = 0.29] and NSE levels [MD = 0.49 ng/ml, 95%CI: − 0.82, 1.80; P = 0.46]. Conclusions: This meta-analysis found elevated serum S100B and NSE levels in OSAS patients compared to the controls, which suggests that these markers may be used as peripheral indicators of brain damage in OSAS.

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Serum S100B but not NSE Levels are Increased in Morbidly Obese Individuals Affected by Obstructive Sleep Apnea–Hypopnea Syndrome

Abstract: Our study shows a significant increase in S100B level after PSG compared to before. This suggests that there is a CNS astrocyte reaction because of possible cerebral hypoxemia in morbidly obese patients with OSAHS.

Cited by 14 publications

References 28 publications

Serum S100B levels in patients with obstructive sleep apnea syndrome

Serum S100B levels in patients with obstructive sleep apnea syndrome

Sleep Apnea in Traumatic Brain Injury: Understanding Its Impact on Executive Function

The effect of obstructive sleep apnea syndrome on serum S100B and NSE levels: a systematic review and meta-analysis of observational studies

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