Serum salusin-α and salusin-β levels in patients with Behcet's disease

Erden, Ilker; Demir, Betül; Uçak, Haydar; Çiçek, Demet; Dertlioğlu, Selma Bakar; Aydın, Süleyman

doi:10.1684/ejd.2014.2397

Cited by 15 publications

(14 citation statements)

References 25 publications

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“… 4 Recent studies have shown that an increased susceptibility to IR was related to chronic inflammation, endothelial dysfunction and metabolic abnormalities in patients with BD. 5 6 …”

Section: Introductionmentioning

confidence: 99%

Novel Myokine: Irisin May be An Independent Predictor for Subclinic Atherosclerosis in BehçEt'S Disease

İçli̇

Cüre

Uslu

et al. 2016

Journal of Investigative Medicine

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Behçet's disease (BD) is a vasculitic and inflammatory disease causing endothelial dysfunction. Irisin is a metabolic hormone related to insulin resistance and endothelial functions. In this study, we investigated the relationship between irisin and carotid intima-media thickness (cIMT), which is a marker of atherosclerosis in patients with BD. 48 patients with BD and 50 healthy individuals were enrolled in the study. Disease severity was evaluated by BD current activity form. Irisin, glucose, insulin, C reactive protein, erythrocyte sedimentation rate and lipid panel were examined in all patients. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was used to calculate insulin resistance. A simple and inexpensive cIMT test was used as indicator of atherosclerosis. cIMT was 0.62 (0.45–1.05) mm in the patients, while it was 0.38 (0.25–0.65) mm in the control group (p<0.001). Irisin value was found to be 197.3 (24.8–834.2) ng/mL in the control group, while it was 85.4 (4.7–471.1) ng/mL in the patient group (p=0.007). There was a negative correlation between irisin level and cIMT (r=−0.511, p<0.001) and HOMA-IR (r=−0.371, p=0.009). Decreased irisin levels (OR 0.996, 95% CI 0.992 to 1.000, p=0.041), male gender (OR 7.634, 95% CI 1.415 to 41.191, p=0.018), and HOMA-IR (OR 2.596, 95% CI 1.451 to 4.643, p=0.001) are independent risk factors for cIMT in patients with BD. We detected a very strong relationship between cIMT, which is an indicator of subclinical atherosclerosis, and decreased irisin levels in patients with BD. BD is characterized by chronic inflammation, and low serum irisin levels in BD may be related to atherosclerosis.

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“… 4 Recent studies have shown that an increased susceptibility to IR was related to chronic inflammation, endothelial dysfunction and metabolic abnormalities in patients with BD. 5 6 …”

Section: Introductionmentioning

confidence: 99%

Novel Myokine: Irisin May be An Independent Predictor for Subclinic Atherosclerosis in BehçEt'S Disease

İçli̇

Cüre

Uslu

et al. 2016

Journal of Investigative Medicine

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“…7,8 Salusin-b has been reported to contribute to vascular remodeling associated with atherosclerosis via inflammatory responses in vascular endothelial cells, and to promote vascular smooth muscle cell proliferation. 9 Salusin-b is also involved in the inflammatory processes associated with myocardial ischemic disease, 10 hypertension, 11 and Behçet disease, 12 which indicates that salusin-b could affect the inflammatory processes associated with PAH.…”

mentioning

confidence: 99%

Salusin-β contributes to vascular inflammation associated with pulmonary arterial hypertension in rats

Zhang

Liu

et al. 2016

The Journal of Thoracic and Cardiovascular Surgery

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“…Prohepcidin, hepcidin, salusin alpha, preptin and amylin amounts are reduced, whereas salusin-beta levels are elevated in Behcet's disease (89).…”

Section: Behcet's Diseasementioning

confidence: 94%

Molecular talk of adipokines in dermatological diseases

Aydın

2016

Cell Mol Biol (Noisy-le-grand)

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Adipose tissue is not a passive tissue storing triglycerides, but one that releases hormones, enzymes, growth factors, and cytokines. Currently, known to release more than 600 adipokines, the adipose is an active tissue involved in energy homeostasis and serving paracrine, autocrine and endocrinal functions. Besides, some adipokines (irisin and ghrelin, for example) are synthesized in the sebaceous glands of the skin and play important roles in certain dermatological diseases. This review will provide a systemic overview of adipokines, focusing on their tissue and organ distribution, functions in biological systems, and roles in dermatological diseases. Additionally, the areas where adipokines can be used in dermatological diseases and their possible future roles will be presented.

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Serum salusin-α and salusin-β levels in patients with Behcet's disease

Cited by 15 publications

References 25 publications

Novel Myokine: Irisin May be An Independent Predictor for Subclinic Atherosclerosis in BehçEt'S Disease

Novel Myokine: Irisin May be An Independent Predictor for Subclinic Atherosclerosis in BehçEt'S Disease

Salusin-β contributes to vascular inflammation associated with pulmonary arterial hypertension in rats

Molecular talk of adipokines in dermatological diseases

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