Serum Sclerostin Levels in Patients with Human Immunodeficiency Virus Infection and Their Association with Bone Turnover Markers and Bone Mineral Densitometry

Almansouri, Abdulrahman Y.; Abdulfatah, Mohammed E.; Baaqil, Omar H.; Bakheet, Alaa Abdulrahman; Turki, Sarah; Kotb, Mamdouh; Althubaiti, Alaa; Almaghrabi, Majed; Althubaiti, Abdulrahman; Madani, Badr; Jawad, Ali

doi:10.11005/jbm.2016.23.1.16

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…In contrast, BMI and SAT were not associated with frailty. Although HIV was associated with increased frailty, the effect of these body composition measurements on frailty did not differ by HIV serostatus [3–5, 31, 32]. In contrast to prior studies linking frailty to low CD4 count and a history of AIDS [8, 33, 34], we did not find an association between frailty and HIV-specific factors, likely reflective of low rates of clinical AIDS and high CD4 T-cell counts.…”

Section: Discussioncontrasting

confidence: 99%

Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV

Hawkins¹,

Zhang

et al. 2018

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Section: Discussioncontrasting

confidence: 99%

Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV

Hawkins¹,

Zhang

et al. 2018

Aids

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“…A previous study in therapy-naïve primary HIV-infected (PHI) men, showed that bone turnover did not differ between those with a normal or a reduced BMD [ 10 ]. However, most other studies show higher BTMs in PHI-men [ 3 , 4 , 6 , 10 , 22 – 24 ]. These heterogeneous data might be caused by the choice of BTM, pre-analytical differences (for instance time of the blood withdrawal, fasting sample or not), the applicable reference interval of the BTM, or differences in patient characteristics (for instance males versus females).…”

Section: Introductionmentioning

confidence: 85%

“…The hip BMD decreased less in the untreated group compared to the treated group. Several underlying mechanisms could result in the further decrease of BMD such as persistent vitamin D deficiency, continued immune activation and cytokine release induced by the HIV-infection itself, and cART effects in the treated group [ 6 , 10 , 12 , 20 , 23 , 26 , 28 , 31 ]. Currently, the European HIV guidelines indicate to screen only persons who are at risk for vitamin D deficiency and not all PHI-patients [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of antiretroviral therapy on bone turnover and bone mineral density in men with primary HIV-1 infection

et al. 2018

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IntroductionPrevious studies indicate that human immunodeficiency virus (HIV)-infection and combination antiretroviral therapy (cART) can affect bone turnover. Furthermore, HIV-infected patients have lower bone mineral density (BMD) compared to a healthy reference population.ObjectiveTo evaluate the longitudinal effect of HIV-infection and cART on bone turnover markers (BTMs) and BMD in men with primary HIV-infection (PHI).Design, methodsThirty-five PHI-men were divided into two groups, those that received cART for the first time (n = 26) versus no-cART (n = 9). Dual-energy X-ray absorptiometry (DXA) was performed on femoral neck (FN), total hip (TH) and lumbar spine (LS) and BTMs (P1NP, alkaline phosphatase, osteocalcin, ICTP and CTX) were measured at baseline and follow-up.ResultsAt baseline, the median CD4+ T-cell count was 455 cells/mm3 (IQR 320–620) and plasma viral load 5.4 log10 copies/mL (IQR 4.7–6.0) in the cART treated group, compared to 630 (IQR 590–910) and 4.8 (IQR 4.2–5.1) in the untreated group. The median follow-up time was 60.7 weeks (IQR 24.7–96.0). All BTMs, except ICTP, showed a significant increase during cART versus no changes of BTMs in the untreated group. FN and TH BMD showed a significant decrease in both groups. LS BMD did not change in both groups.ConclusionBone turnover increased in PHI-men treated with cART which was accompanied by a decrease in FN and TH BMD. No increase of bone turnover was seen in untreated PHI-men. Our study suggests that cART results in increased bone turnover and decreased BMD of the hip in PHI-men.

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“…Serum sclerostin levels were significantly reduced in HIV-infected patients compared to healthy controls. It has been suggested that untreated HIV and/or systemic inflammation may be a major regulator of serum sclerostin [19]. Different results were obtained in HCV, another viral disease.…”

Section: Discussionmentioning

confidence: 99%

SIRS tanılı hastalarda enflamasyon ve kemik döngüsü arasındaki ilişkinin sklerostin ve Dickkopf-1 (DKK-1) düzeyleri ile değerlendirilmesi

Altınışık

AŞIK

2022

Family Practice and Palliative Care

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Introduction: In intensive care units (ICU), patients remain bedridden for a long time. In addition, severe infections are frequently seen in ICUs. Both prolonged immobilization and serious infections are associated with bone tissue loss. The Wnt pathway has recently been focused on evaluating bone tissue loss. The Wnt pathway participates in both infections and the formation of bone tissue. Wnt pathway inhibitors sclerostin and Dickkopf-1 (DKK-1) inhibit bone formation and increase osteoclastic activity. In this study, we aimed to examine bone turnover by the Wnt inhibitors sclerostin and DKK-1 and their possible associations with inflammation in SIRS patients.Methods: We included 30 patients diagnosed with systemic inflammatory response syndrome (SIRS) in the study group and 16 in the control group. Serum sclerostin, DKK-1, white blood cell (WBC), and C-Reactive Protein (CRP) levels on the day of SIRS diagnosis (basal), the 7th, 14th, and 21stdays were evaluated in the study group, and the results were compared with the control group.Results: When the control group was compared with the basal SIRS, there was a significant elevation in both sclerostin (p=0.003) and DKK-1 (p=0.001). Statistical analysis showed significant decreases in sclerostin levels between basal and the 7th, 14th, and 21st days (p=0.033, p=0.003, p=0.002, respectively). Similarly, significant decreases in DKK-1 levels between basal and the 7th and 21st days (p=0.015, p=0.001, respectively) and an insignificant decrease on the 14th day (p=0.191) was observed. Sclerostin was positively and significantly correlated with WBC and CRP in basal and 7th-day measurements and WBC in 7th and 14th days. DKK-1 is positively and significantly correlated with WBC in basal and 7th-daymeasurements, while DKK-1 negatively correlates with CRP in basal-7th-day measurements.Conclusion: In this study, it was shown for the first time that the Wnt antagonists sclerostin and DKK-1 values are high in SIRS patients in ICU. Both biomarker levels decreased in parallel with the treatment. However, it could not be associated with disease severity and inflammatory marker levels. We believe that monitoring the change of Wnt antagonists will be useful in demonstrating bone turnover in patients with SIRS.Keywords: Dickkopf-1, Intensive care unit, Sclerostin, Systemic inflammatory response syndrome, Wnt signaling pathway, Bone turnover

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Serum Sclerostin Levels in Patients with Human Immunodeficiency Virus Infection and Their Association with Bone Turnover Markers and Bone Mineral Densitometry

Cited by 7 publications

References 28 publications

Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV

Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV

Effect of antiretroviral therapy on bone turnover and bone mineral density in men with primary HIV-1 infection

SIRS tanılı hastalarda enflamasyon ve kemik döngüsü arasındaki ilişkinin sklerostin ve Dickkopf-1 (DKK-1) düzeyleri ile değerlendirilmesi

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