Serum miRNA Combined With Transvaginal Color Doppler Ultrasound Diagnosis Clinical Research on Cervical Cancer

Abstract

ObjectivesTo explore clinical value of miRNA‐18a, miRNA‐130a, miRNA‐92a combined with transvaginal color Doppler ultrasound (TVCDS) in diagnosis of cervical cancer (CC).MethodsHundred patients with pathologically confirmed CC (CC group), 100 patients with cervical epithelial neoplasia (disease group), and 100 patients with benign uterine lesions (control group) were selected. TVCDS was performed, and the levels of serum miRNA‐18a, miRNA‐130a, and miRNA‐92a were detected.ResultsThe systolic blood velocity of the cancer group, the disease group and the control group decreased sequentially, while the resistance index and pulsatility index increased sequentially. The serum miR‐18a, miR‐130a, miR‐92a and expression levels of the patients increased sequentially. Multivariate Logistic regression analysis showed that age, HR‐HPV infection, menopause, blood flow RI, serum miRNA‐18a, miRNA‐92a, and miRNA‐130a were the influencing factors of CC. receiver operating characteristic curve showed that the sensitivity, specificity, accuracy and area under curve of transvaginal Doppler ultrasound in the diagnosis of CC were 86.43%, 88.01%, 84.32%, and 0.913; serum miR‐18a were, respectively, 76.56, 81.30, 80.36, and 0.839; serum miR‐130a were 77.88%, 76.97%, 78.32%, and 0.0.864; serum miR‐92a were 71.04%, 80.39%, 80.74%, and 0.894; 90.33%, 95.14%, 91.25%, and 0.947, the AUC of the combined detection of the 3 was greater than that of the single detection.ConclusionsSerum miRNA combined with TVCDS has the advantages of non‐invasive, high sensitivity and high specificity in the diagnosis of CC.