Serum <scp>VCAM</scp>‐1 and <scp>ICAM</scp>‐1 measurement assists for <scp>MACE</scp> risk estimation in <scp>ST</scp>‐segment elevation myocardial infarction patients

Yu, Jiancai; Liu, Yongxing; Peng, Wanzhong; Xu, Zhou

doi:10.1002/jcla.24685

Cited by 14 publications

(11 citation statements)

References 32 publications

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“…ICAM-1 plays a fundamental role in neutrophil crossing of the endothelial cell layer [88]. Yu et al [89] have found that stress [90]. Similarly, we found that both RELA and ICAM-1 were stably upregulated in the disgroup.…”

Section: Discussionsupporting

confidence: 77%

Uncovering the Genetic Link between Acute Myocardial Infarction and Ulcerative Colitis Co-Morbidity through a Systems Biology Approach

Cui¹,

Cai²,

Wu³

et al. 2023

CVIA

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Background: Cardiovascular diseases, particularly acute myocardial infarction, are the leading cause of disability and death. Atherosclerosis, the pathological basis of AMI, can be accelerated by chronic inflammation. Ulcerative colitis (UC), a chronic inflammatory disease associated with immunity, contributes to the risk of AMI development. However, controversy continues to surround the relationship between these two diseases. The present study unravels the pathogenesis of AMI and UC, to provide a new perspective on the clinical management of patients with these comorbidities. Methods: Microarray datasets GSE66360 and GSE87473 were downloaded from the Gene Expression Omnibus database. Common differentially expressed genes (co-DEGs) between AMI and UC were identified, and the following analyses were performed: enrichment analysis, protein-protein interaction network construction, hub gene identification and co-expression analysis. Results: A total of 267 co-DEGs (233 upregulated and 34 downregulated) were screened for further analysis. GO enrichment analysis suggested important roles of chemokines and cytokines in AMI and UC. In addition, the lipopolysaccharide-mediated signaling pathway was found to be closely associated with both diseases. KEGG enrichment analysis revealed that lipid and atherosclerosis, NF-κB, TNF and IL-17 signaling pathways are the core mechanisms involved in the progression of both diseases. Finally, 11 hub genes were identified with cytoHubba: TNF, IL1B, TLR2, CXCL8, STAT3, MMP9, ITGAX, CCL4, CSF1R, ICAM1 and CXCL1. Conclusion: This study reveals a co-pathogenesis mechanism of AMI and UC regulated by specific hub genes, thus providing ideas for further mechanistic studies, and new perspectives on the clinical management of patients with these comorbidities.

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Section: Discussionsupporting

confidence: 77%

Uncovering the Genetic Link between Acute Myocardial Infarction and Ulcerative Colitis Co-Morbidity through a Systems Biology Approach

Cui¹,

Cai²,

Wu³

et al. 2023

CVIA

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“…The models sharing identical predictor variables and stemming from the same study population, yet predicting MACE at varying time intervals, were categorized as one model. A total of 12 studies addressed prognostic models for patients with ST-segment elevation myocardial infarction (STEMI) ( 20 , 26 – 29 , 32 – 34 , 36 – 39 ). Six studies were centered on patients with myocardial infarction (MI) ( 11 , 12 , 21 , 22 , 24 , 35 ).…”

Section: Resultsmentioning

confidence: 99%

“…Approximately 91.3% of the studies ( n = 21) were constructed using Chinese populations, while one study ( 31 ) was based on England individuals, and another study ( 37 ) was based on Spain individuals. The models developed in the eight studies ( 21 , 24 , 25 , 30 , 33 , 37 , 39 ) did not undergo either internal or external validation. Three studies performed external validation by enrolling patients at different times ( 11 , 31 , 35 ).…”

Section: Resultsmentioning

confidence: 99%

“…All models employed regression analysis, with 15 studies ( 12 , 20 – 25 , 27 , 28 , 30 , 31 , 34 – 36 , 38 ) using logistic regression, while eight studies ( 11 , 13 , 26 , 29 , 32 , 33 , 37 , 39 ) using Cox regression. The models were ultimately presented in various forms, such as formulas ( 22 , 30 , 31 ), risk scores ( 35 , 37 ), nomograms ( 12 , 13 , 20 , 21 , 25 – 29 , 36 , 38 , 39 ), or combinations thereof. Detailed information regarding the modeling methods, variable selecting methods, calibration method, and model presentation can be found in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

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Prediction models for major adverse cardiovascular events after percutaneous coronary intervention: a systematic review

Deng,

Wang,

Wan

et al. 2024

Front. Cardiovasc. Med.

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BackgroundThe number of models developed for predicting major adverse cardiovascular events (MACE) in patients undergoing percutaneous coronary intervention (PCI) is increasing, but the performance of these models is unknown. The purpose of this systematic review is to evaluate, describe, and compare existing models and analyze the factors that can predict outcomes.MethodsWe adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 during the execution of this review. Databases including Embase, PubMed, The Cochrane Library, Web of Science, CNKI, Wanfang Data, VIP, and SINOMED were comprehensively searched for identifying studies published from 1977 to 19 May 2023. Model development studies specifically designed for assessing the occurrence of MACE after PCI with or without external validation were included. Bias and transparency were evaluated by the Prediction Model Risk Of Bias Assessment Tool (PROBAST) and Transparent Reporting of a multivariate Individual Prognosis Or Diagnosis (TRIPOD) statement. The key findings were narratively summarized and presented in tables.ResultsA total of 5,234 articles were retrieved, and after thorough screening, 23 studies that met the predefined inclusion criteria were ultimately included. The models were mainly constructed using data from individuals diagnosed with ST-segment elevation myocardial infarction (STEMI). The discrimination of the models, as measured by the area under the curve (AUC) or C-index, varied between 0.638 and 0.96. The commonly used predictor variables include LVEF, age, Killip classification, diabetes, and various others. All models were determined to have a high risk of bias, and their adherence to the TRIPOD items was reported to be over 60%.ConclusionThe existing models show some predictive ability, but all have a high risk of bias due to methodological shortcomings. This suggests that investigators should follow guidelines to develop high-quality models for better clinical service and dissemination.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=400835, Identifier CRD42023400835.

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“…Furthermore, TNF-α promotes the interconnection between the endothelium and circulating leukocytes by the upregulation of adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) ( 10 ). High levels of VCAM-1 and ICAM-1 have been described as an independent risk of major adverse cardiac events ( 18 ). The expression of ICAM-1 and VCAM-1 is associated with intestinal disease activity, demonstrated by the reduction of their serum concentration after treatment ( 10 , 19 ).…”

Section: Pathological Mechanisms Shared By Ibd and Atherosclerotic Ca...mentioning

confidence: 99%

Atherosclerotic cardiovascular diseases in inflammatory bowel diseases: to the heart of the issue

Gabbiadini

Buono

Mastrorocco

et al. 2023

Front. Cardiovasc. Med.

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Atherosclerotic cardiovascular disease and stroke are the leading causes of morbidity and mortality worldwide. Along to the traditional risk factors for these diseases, chronic inflammation is known to be an important player in accelerating the process of atherosclerosis, which can result in an increased incidence of arterial thromboembolic events. As in other chronic inflammatory diseases, in the past few years, several studies suggested that subjects affected by inflammatory bowel diseases (IBD) may also be at an incremented risk of atherosclerotic disease, especially during the periods of disease's flare. Therefore, IBD treatment may assume an important role for achieving both disease remission and the control of the atherosclerotic risk. In this article we aimed to perform a comprehensive review on evidence on the increased risk of arterial thromboembolic events in patients affected by IBD and discuss the potential role of IBD therapy in reducing this risk.

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Serum VCAM‐1 and ICAM‐1 measurement assists for MACE risk estimation in ST‐segment elevation myocardial infarction patients

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 14 publications

References 32 publications

Uncovering the Genetic Link between Acute Myocardial Infarction and Ulcerative Colitis Co-Morbidity through a Systems Biology Approach

Uncovering the Genetic Link between Acute Myocardial Infarction and Ulcerative Colitis Co-Morbidity through a Systems Biology Approach

Prediction models for major adverse cardiovascular events after percutaneous coronary intervention: a systematic review

Atherosclerotic cardiovascular diseases in inflammatory bowel diseases: to the heart of the issue

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