Serum Selenium and Peripheral Arterial Disease: Results From the National Health and Nutrition Examination Survey, 2003-2004

Abstract

The authors conducted a cross-sectional study of the association of serum selenium with the prevalence of peripheral arterial disease among 2,062 US men and women 40 years of age or older participating in the National Health and Nutrition Examination Survey, 2003-2004. Serum selenium was measured by using inductively coupled plasma-dynamic reaction cell-mass spectrometry. Peripheral arterial disease was defined as an ankle-brachial blood pressure index <0.90. The age-, sex-, and race-adjusted prevalence of peripheral arterial disease decreased with increasing serum selenium (P for linear trend = 0.02), but there was an indication of an upturn in risk in the highest quartile of serum selenium. The fully adjusted odds ratios for peripheral arterial disease comparing selenium quartiles 2, 3, and 4 with the lowest quartile were 0.75 (95% confidence interval: 0.37, 1.52), 0.58 (95% confidence interval: 0.28, 1.19), and 0.67 (95% confidence interval: 0.34, 1.31), respectively. In spline regression models, peripheral arterial disease prevalence decreased with increasing serum selenium levels up to 150-160 ng/mL, followed by a gradual increase at higher selenium levels. The association between serum selenium levels and the prevalence of peripheral arterial disease was not statistically significant, although a U-shaped relation was suggested.

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

“…Our result is in opposition with most European surveys (Arnaud et al, 2006;Meplan et al, 2007;Ortega et al, 2012) or US populations (Bleys et al, 2009), in which obese patients have lower serum selenium concentration, but in agreement with Dewailly's survey of a French Polynesian sampling in which selenium concentration in blood was positively linked to BMI , the regression coefficient (β) being 0.02, i.e. ten times higher than in our study, among the controls (β=0.002).…”

Selenium status and cardiometabolic health: State of the evidence

“…50 However, recent observational evidence in selenium-replete populations such as that of the US is suggestive of a possible U-shaped association (Figure 1) between selenium status and CVD. [48][49] Results from randomized trials of selenium supplementation do not support a role for selenium in cardiovascular prevention at the present time. …”

“…[43][44][45][46][47][48][49] Inverse associations have been found particularly in populations with relatively low selenium intake or status. [43][44][45][46][47] For instance, in a German population of 636 patients with suspected coronary artery disease, mean plasma selenium was 69.5 and 74.5 µg/L at baseline in patients with and without a recurring cardiovascular event, respectively.…”

Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens

“…The association between ischemic heart disease and selenium has been reported in several studies (8)(9)(10). Salonen et al observed a 2.9-fold increased risk of cardiovascular death in patients with low selenium levels (11) However, the efficacy of selenium supplementation as a single dietary additive has been debated (8)(9)(10)12). Absence of clinical effects may, in some cases, be explained by short-term intervention periods and/or low selenoprotein activity due to concomitant coenzyme Q10 deficiency, a nutrient necessary for selenoprotein synthesis (13).…”

“…have proposed that selenium affects tumour development (7). The association between ischemic heart disease and selenium has been reported in several studies (8)(9)(10). Salonen et al observed a 2.9-fold increased risk of cardiovascular death in patients with low selenium levels (11) However, the efficacy of selenium supplementation as a single dietary additive has been debated (8)(9)(10)12).…”