Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study

Lubos, Edith; Sinning, Christoph; Schnabel, Renate B.; Wild, Philipp S.; Zeller, Tanja; Rupprecht, Hans J.; Bickel, Christoph; Lackner, Karl J.; Peetz, D.; Loscalzo, Joseph; Münzel, Thomas; Blankenberg, Stefan

doi:10.1016/j.atherosclerosis.2009.09.008

Cited by 76 publications

(45 citation statements)

References 27 publications

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“…Although it appears that selenium supplementation has no effect on CVD risk in healthy individuals, in a very recent AtheroGene study, low selenium concentration was associated with future cardiovascular death in patients with acute coronary syndrome, although no effect on stable angina pectoris (232). Further, in the selenium Therapy in Coronary Artery disease Patients (SETCAP) Study, supplementation of sodium selenite increased GPx1 activity in endothelial cells and in coronary artery disease (CAD) patients.…”

Section: A Cardiovascular Diseasementioning

confidence: 97%

Selenium in Human Health and Disease

Fairweather‐Tait

Bao

Broadley

et al. 2011

Antioxidants & Redox Signaling

1,092

820

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This review covers current knowledge of selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system. Selenium toxicity and links between deficiency and Keshan disease and Kashin-Beck disease are described. The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility, are reviewed, and recent developments in genetics of selenoproteins are outlined. The rationale behind current dietary reference intakes of selenium is explained, and examples of differences between countries and/or expert bodies are given. Throughout the review, gaps in knowledge and research requirements are identified. More research is needed to improve our understanding of selenium metabolism and requirements for optimal health. Functions of the majority of the selenoproteins await characterization, the mechanism of absorption has yet to be identified, measures of status need to be developed, and effects of genotype on metabolism require further investigation. The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies.

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Section: A Cardiovascular Diseasementioning

confidence: 97%

Selenium in Human Health and Disease

Fairweather‐Tait

Bao

Broadley

et al. 2011

Antioxidants & Redox Signaling

1,092

820

View full text Add to dashboard Cite

show abstract

“…Data from many studies about the associations between selenium and cardiometabolic risk factors were inconsistent. Previous populationbased studies have reported inverse correlations between serum selenium levels and cardiovascular mortality [13,39]. Obeid et al reported that there was a positive correlation between plasma selenium levels and all the components of metabolic syndrome [40].…”

Section: Discussionmentioning

confidence: 98%

“…Selenium is also an essential mineral that plays an important role in the antioxidant defense by participating in the structure of selenocysteine and glutathione peroxidase enzymes [12]. Several studies have reported association between low selenium concentrations and increased risk of cardiometabolic disease [13].…”

Section: Introductionmentioning

confidence: 99%

Trace Element Levels in Congenital Hypogonadotrophic Hypogonadism

Aydoğdu

Haymana

Soykut

et al. 2015

Biol Trace Elem Res

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Cardiometabolic diseases are prevalent in hypogonadism. The pathophysiologic mechanism of increased cardiometabolic risk in hypogonadal patients is not clear. Recently, trace elements have been linked to the development of chronic disease especially cardiovascular disease. We investigated the trace element levels in an unconfounded population of congenital hypogonadotrophic hypogonadism (CHH) and also searched for the relationship with metabolic risk factors. A total of 89 patients with CHH (mean age 21.8 ± 2.0 years) and 80 healthy control subjects (mean age 21.3 ± 1.1 years) were enrolled. The demographic parameters, homeostatic model assessment of insulin resistance (HOMA-IR) levels and plasma zinc, copper, and selenium levels, were measured in patients and healthy controls. The patients had higher waist circumferences (p = 0.014), triglyceride (p = 0.04), insulin (p = 0.004), HOMA-IR levels (p = 0.001), and lower selenium (p = 0.049), zinc (p = 0.004), and copper (p = 0.012) levels when compared to the healthy controls. There was a significant relationship between zinc levels and HOMA-IR levels (p = 0.015). In the regression analysis, zinc levels were independently associated with the calculated HOMA-IR levels (p = 0.015). The results of the present study show that plasma selenium, zinc, and copper levels are decreased in patients with CHH. Also, plasma zinc levels are independently associated with insulin resistance in patients with hypogonadism. Long-term follow-up studies are warranted to investigate the effect of trace elements on the increased cardiometabolic risk in hypogonadism.

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“…2 It has been reported that, Se and GSHPx participate in epilepsy pathogenesis. 3 The immuno-enhancing 4,5 , anti-viral [6][7][8] , cancer prevention 9-13 effects of Se, the protective role of Se against radiation, 14,15 cardiovascular diseases, 16,17 and reproductive disorders 18,19 have also been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Mapping of Selenium Metabolic Pathway in Yeast by Liquid Chromatography−Orbitrap Mass Spectrometry

et al. 2010

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A high resolution mass spectrometric detection method is described for the identification of key metabolites in the selenium pathway in selenium enriched yeast. Iodoacetic acid (IAA) was used as the derivatizing reagent to stabilize the selenols. Oxidized forms of Selenocysteine (Se-Cys), selenohomocystine (Se-HCys), selenoglutathione (Se-GSH), seleno-γ-glutamyl-cysteine (Se-Glu-Cys), N-(2,3-dihydroxy-1-oxopropyl)-Selenocysteine (SELM-1). Selenols were also derivatized with a mercury tag, p-hydroxymercurybenzoate (PHMB). The selenol-PHMB complexes showed the overlapped isotopic patterns of selenium and mercury, which provided supporting information for the identification of selenols. Both methods showed good agreement (< 4 ppm difference) between the theoretical masses of the target compounds and the measured masses in the yeast matrix. The method using IAA as the derivatizing reagent was used to study the response of Saccharomyces cerevisiae to three forms of selenium, Se-Met, Na 2 SeO 3 (Se (IV)), and Na 2 SeO 4 ·10H 2 O (Se (VI)) (concentration of Se: 100 mg/L). The production of selenocompounds observed over a six hour period was high in the Se-Met treated group compared to the groups treated with Se (IV), Se (VI).

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Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study

Cited by 76 publications

References 27 publications

Selenium in Human Health and Disease

Selenium in Human Health and Disease

Trace Element Levels in Congenital Hypogonadotrophic Hypogonadism

Mapping of Selenium Metabolic Pathway in Yeast by Liquid Chromatography−Orbitrap Mass Spectrometry

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