Serum selenium levels in Saudi new-borns

Al‐Saleh, Iman; Al-Doush, Inaam; Ibrahim, Marwan A.; Rabbah, Abdullah

doi:10.1080/09603129873372

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…Infant blood Se status, according to more than one study in the Middle East, is within the normal range [ 103 , 115 ], while one study in Yemeni infants found Se blood status to be very low [ 113 ]. However, studies that date back to the 1990s indicate low Se content in breast milk [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

A Review of Dietary Selenium Intake and Selenium Status in Europe and the Middle East

Stoffaneller

Morse²

2015

Nutrients

297

188

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This is a systematic review of existing data on dietary selenium (Se) intake and status for various population groups in Europe (including the United Kingdom (UK)) and the Middle East. It includes English language systematic reviews, meta-analyses, randomised controlled trials, cohort studies, cross-sectional and case-control studies obtained through PUBMED searches from January, 2002, to November, 2014, for European data and from 1990 to November 2014, for Middle Eastern data. Reports were selected if they included data on Se intake and status. The search identified 19 European/UK studies and 15 investigations in the Middle East that reported Se intake and Se concentration in water and/or food and 48 European/UK studies and 44 investigations in the Middle East reporting Se status. Suboptimal Se status was reported to be widespread throughout Europe, the UK and the Middle East, and these results agreed with previous reports highlighting the problem. Eastern European countries had lower Se intake than Western European countries. Middle Eastern studies provided varying results, possibly due to varying food habits and imports in different regions and within differing socioeconomic groups. In conclusion, Se intake and status is suboptimal in European and Middle Eastern countries, with less consistency in the Middle East.

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Section: Resultsmentioning

confidence: 99%

A Review of Dietary Selenium Intake and Selenium Status in Europe and the Middle East

Stoffaneller

Morse²

2015

Nutrients

297

188

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“…Such findings are not surprising since shortened gestations hinder appropriate transport of Se from the mother to the fetus. In fact, Al-Saleh et al ( 42 ) emphasised that pre-term newborns can be at risk of Se deficiency, especially if total parenteral nutrition is needed. Moreover, as a consequence of their lower Se status, pre-term infants might have their antioxidant defences impaired, especially with respect to GPx activity, a Se-dependent enzyme, which may be related to higher incidence of oxygen dependence at 28 d of life ( 44 , 45 ) .…”

Section: Selenium Status and Adverse Fetal And Perinatal Outcomesmentioning

confidence: 99%

The possible role of selenium status in adverse pregnancy outcomes

et al. 2011

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The present study reviews the possible role of Se status during pregnancy regarding adverse pregnancy outcomes, with emphasis on those related to diminished antioxidant activity and increased oxidative stress. Studies have reported that Se could play an important role in adverse outcomes such as miscarriages, neural tube defects, diaphragmatic hernia, premature birth, low birth weight, pre-eclampsia, glucose intolerance and gestational diabetes. Also, low Se status has been associated with adverse outcomes among HIV-infected pregnant women and their offspring. Nevertheless, the function of Se in the aetiology of pregnancy complications is yet to be elucidated. Available evidence presents the following limitations: most study designs do not allow conclusions about causal relationships; study populations, selection of subjects, research setting, procedures for defining sample size and analytical methods are often poorly described; many studies fail to adjust for important confounding variables. In addition, population studies assessing the relationship between Se intake during pregnancy and health outcomes are scarce. Further research is still needed to clarify the role of Se status in adverse pregnancy outcomes, especially those related to augmented oxidative stress.

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“…The available literature shows that highly plausible diseases associated with selenium deficiency appear to be a distinct possibility due to the low levels of selenium found in the soil, alfalfa grass, and water, and as reflected in the toenails in the area tested [6,8,9,11]. Although the soil selenium levels could vary from place to place, the very fact that low soil selenium exists in a given sector of Saudi Arabia suggests that it could likewise exist in other parts of the country.…”

Section: Discussionmentioning

confidence: 99%

“…Selenium is vital for good health [1-5]. Al-Saleh and coworkers [6] measured selenium in 300 umbilical cord blood samples collected from healthy pregnant women in Al-Kharj area in Saudi Arabia which showed serum selenium levels of 40.847 ± 8.969 μg/L in 300 newborns. Of interest, the cord serum selenium level was significantly lower in preterm infants than full-term infants (32 ± 8.029 μg/L versus 41.323 ± 8.784 μg/L).…”

Section: Introductionmentioning

confidence: 99%

Selenium: a brief review and a case report of selenium responsive cardiomyopathy

2013

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BackgroundThe authors review the role of selenium and highlight possible low selenium levels in soil that may result in deficient states in Saudi Arabia.Case presentationThe authors report a case of selenium-responsive cardiomyopathy in a 15-month old Saudi Arabian boy. This case of selenium deficiency causing dilated cardiomyopathy is presented with failure to thrive, prolonged fever and respiratory distress. The investigations revealed selenium deficiency. Selenium supplementation along with anti-failure therapy [Furosimide, Captopril] was administered for 6 months. Following therapy the cardiac function, hair, skin and the general health of the patient improved significantly.ConclusionThe patient with dilated cardiomyopathy of unknown etiology, not responding to usual medication may be deficient in selenium. Serum selenium measurements should be included in the diagnostic work-up to ensure early detection and treatment of the disease. The selenium level in the Saudi population needs be determined. Vulnerable populations have to undergo regular selenium measurements and supplementation if indicated. Dependence on processed foods suggests that the Saudi population fortify themselves with nutrient and micronutrient supplements in accordance to the RDA.

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Serum selenium levels in Saudi new-borns

Cited by 11 publications

References 24 publications

A Review of Dietary Selenium Intake and Selenium Status in Europe and the Middle East

A Review of Dietary Selenium Intake and Selenium Status in Europe and the Middle East

The possible role of selenium status in adverse pregnancy outcomes

Selenium: a brief review and a case report of selenium responsive cardiomyopathy

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