Serum Serotonin as a Potential Diagnostic Marker for Hepatocellular Carcinoma

Mamdouh, Fatma; Alem, Shereen Abdel; Abdelaal, Amaal; Salem, Ahmed; Rabiee, Ahmed; Elsisi, Ola

doi:10.1089/jir.2019.0088

Cited by 11 publications

(11 citation statements)

References 24 publications

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“…Our results were similar to those of the study that showed that serum serotonin can be a promising biomarker to follow-up patients who are at risk of developing HCC and for an early diagnosis of HCC. 18 However, there are several opposite results to our study. Liu et al 19 found that HCC patients had significantly higher levels of portal vein serum and HCC tissue of L -tryptophan than healthy controls; these higher levels were related to impaired liver function and poor survival.…”

Section: Discussioncontrasting

confidence: 99%

Serum Amino Acid Profiles Predict the Development of Hepatocellular Carcinoma in Patients with Chronic HBV Infection

Zheng

Yang

et al. 2022

ACS Omega

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Background: The study aimed to find out the alterations in serum amino acid (AA) profiles and to detect their relationship with carcinoma formation. Methods: Targeted metabolomics based on ultraperformance liquid chromatography triple quadrupole mass spectrometry to quantitatively analyze serum AA levels in 136 hepatitis B (CHB) patients and 93 hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. Results: It was shown that decreased serum levels of leucine, lysine, threonine, tryptophan, valine, serotonin, and taurine were observed in more HCC patients than CHB patients, but the serum phenylalanine level was increased. Serum valine and serotonin were lower in Class C than Class A and Class B in HCC patients. Accompanied with the higher score of Model for End-Stage Liver Disease, serum phenylalanine was increased not only in CHB patients but also in HCC patients. The serum level of phenylalanine increased in the decompensated stage more than in the compensated stage, while serum leucine and serotonin significantly decreased. Serum serotonin still had significant differences between CHB and HCC both in the HBV desoxyribonucleic acid (HBV-DNA) negative group and in the HBV-DNA positive group. Furthermore, it was shown that the tryptophan ratio, branched-chain amino acids (BCAA)/aromatic amino acids ratio, BCAAs/tyrosine ratio, Fischer’s ratio, and serotonin-to-tryptophan ratio significantly decreased, while the tyrosine ratio and the kynurenine-to-tryptophan ratio increased in HCC patients more than those in CHB. Conclusions: A distinct metabolite signature of some specific serum amino acids was found between CHB and HCC patients, which may help predict the development of HCC at an early stage.

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Section: Discussioncontrasting

confidence: 99%

Serum Amino Acid Profiles Predict the Development of Hepatocellular Carcinoma in Patients with Chronic HBV Infection

Zheng

Yang

et al. 2022

ACS Omega

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“…Elevated plasma 5‐HT levels, measured by a commercial radioimmunoassay kit, suggested being used as a prognostic biomarker of recurrence and poor survival in CRC patients (Xia et al, 2018). Elevation of serum 5‐HT levels, measured by a high‐performance liquid chromatography‐fluorescent detection method, also offered that the serum level of 5‐HT may be increased in HCC (Mamdouh et al, 2019). In a similar study, the lower levels of serum 5‐HT were considered in an enzyme‐linked immunosorbent antibody technique and identified as a non‐invasive biomarker of newly diagnosed FM in women.…”

Section: Trp Metabolites; Biomarkers In Various Disordersmentioning

confidence: 99%

Interactive relationship between Trp metabolites and gut microbiota: The impact on human pathology of disease

Khoshnevisan

Chehrehgosha

Conant

et al. 2022

Journal of Applied Microbiology

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Tryptophan (Trp), an α‐amino acid, is the precursor of serotonin (5‐hydroxytryptamine, 5‐HT), which is involved in a variety of features of metabolic function and human nutrition. Evidence highlights the role of Trp metabolites (exclusively 5‐HT) in the gastrointestinal (GI) tract; however, the mechanisms of action involved in the release of 5‐HT in the GI tract are still unknown. Considering the fact that variations of 5‐HT may facilitate the growth of certain GI disorders, gaining a better understanding of the function and release of 5‐HT in the GI tract would be beneficial. Additionally, investigating Trp metabolism may clarify the relationship between Trp and gut microbiota. It is believed that other metabolites of Trp (mostly that of the kynurenine pathway) may play a significant role in controlling gut microbiota function. In this review, we have attempted to summarize the current research investigating the relationship of gut microbiota, Trp and 5‐HT metabolism (with particular attention paid to their metabolite type, as well as a discussion of the research methods used in each study). Taking together, regarding the role that Trp/5‐HT plays in a range of physical and mental diseases, the gut bacterial types, as well as the related disorders, have been exclusively considered.

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“…The alteration of 5-HT and 5-HT receptor expression patterns leads to dysregulation of epithelial homeostasis which has been associated with breast cancer initiation, progression and tumorigenesis [6][7][8][9][10]. Furthermore, it is shown that 5-HT has been linked to the development of other cancers [11][12]. These studies have suggested that 5-HT acts as a mitogenic signal for cancer cells and, contributes to cell proliferation in various cancers including breast cancer [5,9].…”

Section: Introductionmentioning

confidence: 99%

Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1

et al. 2022

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Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and associated with poor prognosis and shorter survival due to signi cant genetic heterogeneity, drug resistance and lack of effective targeted therapeutics. Therefore, novel molecular targets and therapeutic strategies are needed to improve patient survival. Serotonin (5-hydroxytriptamine, 5-HT) has been shown to induce growth stimulatory effects in breast cancer. However, the molecular mechanisms by which 5-HT exerts its oncogenic effects in TNBC still are not well understood. In the present study, we demonstrated that 5-HT induces cell proliferation of TNBC cells and expression of 5-HT7 receptor and FOXM1 oncogenic transcription factor. We found that expression of 5-HT7 receptor is up-regulated in TNBC cells and higher 5-HT7 expression is associated with poor patient prognosis and shorter patient survival. Genetic and pharmacological inhibition of 5-HT7 by siRNA and metergoline, respectively, suppressed TNBC cell proliferation and FOXM1 and its downstream mediators, including eEF2-Kinase (eEF2K) and cyclin-D1.Overall, our ndings suggest for the rst time that the 5-HT7 receptor promotes FOXM1, eEF2K and cyclin D1 signaling to support TNBC cell proliferation, thus inhibition of 5-HT7/FOXM1 signaling may be used as a potential therapeutic strategy for targeting TNBC.

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Serum Serotonin as a Potential Diagnostic Marker for Hepatocellular Carcinoma

Cited by 11 publications

References 24 publications

Serum Amino Acid Profiles Predict the Development of Hepatocellular Carcinoma in Patients with Chronic HBV Infection

Serum Amino Acid Profiles Predict the Development of Hepatocellular Carcinoma in Patients with Chronic HBV Infection

Interactive relationship between Trp metabolites and gut microbiota: The impact on human pathology of disease

Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1

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