Serum Sickness and Anaphylaxis

Kojis, Ferdinand G.

doi:10.1001/archpedi.1942.02010070094011

Cited by 42 publications

(4 citation statements)

References 163 publications

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“…Children developed fever, arthralgia, lymphadenopathy and cutaneous eruptions 8–12 days after subcutaneous injection with horse serum containing diphtheria antitoxin. Urticarial eruptions, occurring in approximately 91% of cases, represented the most common cutaneous finding . Less commonly, patients also presented with morbilliform and purpuric rashes.…”

Section: Discussionmentioning

confidence: 99%

“…Urticarial eruptions, occurring in approximately 91% of cases, represented the most common cutaneous finding. 8 Less commonly, patients also presented with morbilliform and purpuric rashes. A prospective clinical study confirmed the presence of circulating serum immune complexes, and perivascular deposits on direct immunofluorescence testing of the skin of patients with serum sickness.…”

Section: Discussionmentioning

confidence: 99%

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Serum sickness‐like drug reaction: two cases with a neutrophilic urticarial pattern

Nguyen

Miller

2016

J Cutan Pathol

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The diagnosis of serum sickness-like reaction (SSLR) is typically based on clinical findings. Histopathologic examination is often deferred, as these eruptions commonly present in young children, and often to primary care providers. A PubMed literature search revealed only five existing cases of SSLR which describe cutaneous histopathologic features. We report two cases of SSLR, one each to bupropion and cefazolin. Skin biopsy findings in both cases showed a neutrophil-predominant urticarial pattern resembling neutrophilic urticaria or neutrophilic urticarial dermatosis. We also provide a summary of the histopathologic findings that can help support a diagnosis of SSLR.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum sickness‐like drug reaction: two cases with a neutrophilic urticarial pattern

Nguyen

Miller

2016

J Cutan Pathol

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“…Samples from the 11 reactive Thai patients were also tested by the conglutinin binding assay. Immune complexes were detected by one or more assays in six patients, but in all cases they were present in samples taken before skin tests were performed and after treatment.…”

Section: Immunological Studiesmentioning

confidence: 99%

Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites.

Malasit¹,

Warrell²,

Chanthavanich³

et al. 1986

BMJ

219

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Victims of snake bites are often subjected to cutaneous or conjunctival hypersensitivity testing before being given antivenom. None of 12 early (anaphylactic) reactions was predicted by these tests in 25 Nigerian and Thai patients. The incidence and severity of early reactions was the same whether antivenom was given by intravenous injection over 10 minutes or diluted and given as an intravenous infusion over 30 minutes. Although antivenom activated complement in vitro, there was no evidence of complement activation or formation of immune complexes in patients bitten by snakes who were treated with antivenom, whether or not they developed early reactions. Higher doses of antivenom might induce the complement activation and formation of immune complexes (aggregates) that have been observed during the clinically more severe reactions associated with homologous immunoglobulin treatment.

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“…These serious and occasionally fatal accidents have been summarized by Lamson (5), Kojis (2) and Ratner (4). Kojis collected reports of 61 cases previous to 1942, and added four cases.…”

Section: Symptomsmentioning

confidence: 99%

Serum Sickness – 1957

Sherman¹

1958

Int Arch Allergy Immunol

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Serum Sickness and Anaphylaxis

Cited by 42 publications

References 163 publications

Serum sickness‐like drug reaction: two cases with a neutrophilic urticarial pattern

Serum sickness‐like drug reaction: two cases with a neutrophilic urticarial pattern

Prediction, prevention, and mechanism of early (anaphylactic) antivenom reactions in victims of snake bites.

Serum Sickness – 1957

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