Serum Sickness-Like Reaction: Drug-Induced Cutaneous Disease in a Child

Araujo, Ana Carolina Galvão dos Santos de; Almeida, Liana Moura de; Almeida, Ana Paula Moura de; Oliveira, Elisa Fontenelle de; Rochael, Mayra Carrijo; Morais, Rodrigo Aires de; Rezende, Hudson Dutra

doi:10.5826/dpc.1103a29

Cited by 1 publication

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Диф фе ренциальная диагностика проводилась с острым геморрагическим отеком детского возраста, эозинофильным кольцевидным дерматозом, мигрирующей эритемой, кожными проявлениями красной волчанки, маргинальной эритемой, микозом гладкой кожи, центробежной кольцевидной эритемой, уртикарным васкулитом, многоформной экссудативной эритемой, кожными проявлениями васкулита мелких сосудов кожи. ОБСУЖДЕНИЕ SSLR может развиваться у взрослых пациентов, но большинство случаев описаны у детей [8,9]. Распространенность SSLR неизвестна.…”

Section: предварительный диагнозunclassified

“…Воспаление суставов является особенностью SSLR и обычно характеризуется симметричным их вовлечением с развитием отека и артралгий. По последним данным, до 60% детей с SSLR имели поражение двух и более суставов [3,8], у половины больных заболевание протекает с лихорадкой [16].…”

Section: предварительный диагнозunclassified

See 1 more Smart Citation

Serum Sickness-Like Reaction Associated with Epstein – Barr Virus: Clinical Case

Ivanchikov

Мурашкин

Амбарчян

et al. 2022

Vopr. sovr. pediatr.

View full text Add to dashboard Cite

Background. Annular dermatoses are a group of diseases with major clinical manifestation of rashes of relevant form. This manifestation pattern causes difficulties in diagnosis. The case of rarely diagnosed annular dermatosis is presented: serum siknesslike reaction (SSLR) triggered by the Epstein – Barr virus (EBV). Clinical case description. Patient D., 8 years old girl, noted abdominal pain 3 weeks before hospitalization, and later numerous polymorphic rashes (erythematous macules, urticarial elements), swelling and pain in joints. Self-treatment with non-steroidal anti-inflammatory and systemic antihistamines did not lead to any improvement. The patient was hospitalized in the pediatric department at the place of residence, where the diagnosis “Henoch-Schonlein purpura, mixed type” was established according to the results of physical, laboratory (double increase of ALT and AST, ESR up to 166 mm/h, IgM to EBV), and ultrasound (mesenteric lymph nodes hyperplasia) studies. Systemic glucocorticosteroids have led to improvement, however, few days after the end of the treatment there was relapse of rash and arthralgia. Thus, the girl was administrated to clinical diagnostic center. Patient’s general condition was satisfactory at the time of examination. There were numerous erythematous annular urticarial and macular elements (3–12 cm) on the skin of face, body and limbs. Some foci, as well as some resolved rashes had blue spots with indistinct boundaries that disappeared after compression. Mucous membranes, nails and hair were intact. Subjective symptoms — slight burning around rashes, at palpation — low-intensity pain in the left radiocarpal joint. Blood tests: C-reactive protein concentration increased up to 12 mg/L, ESR up to 26 mm/h, IgG to EBV up to 47.7. Conclusion. During differential diagnosis we should consider the possibility of SSLR development in all pediatric patients with annular rashes associated with arthralgia and/or arthritis, fever, history of drug use (most often beta-lactam antibiotics), recent vaccination or manifestations of viral infection, especially in case of cyanotic spots after rashes resolution and non-specific laboratory parameters.

show abstract

Section: предварительный диагнозunclassified