Serum soluble nucleosome and the broad family of antinucleosome antibodies are associated with organ and tissue damage in systemic lupus erythematosus in a Chinese population

Wu, Ou; Liu, H. H.; Li, W. X.; Zhang, N.; Wang, Q.; Li, X. P.; Dong, Maxia; Zhang, X. J.; Ye, D. Q.

doi:10.1111/j.1365-2230.2007.02669.x

Cited by 11 publications

(3 citation statements)

References 8 publications

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“…Initial reports defined EPDS as chronic pustular eruption of the scalp of elderly patients, with no identifiable cause [11]. Therefore, we should diagnose our case and another similar case [12] as EPDS-like eruption due to EGFR inhibitors, although these cases clinically resemble EPDS. A case of erlotinib-induced acneiform eruption that spared the previously irradiated skin was reported [13].…”

Section: Discussionmentioning

confidence: 83%

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Erosive Pustular Dermatosis of the Scalp-Like Eruption due to Gefitinib: Case Report and Review of the Literature of Alopecia Associated with EGFR Inhibitors

Toda

Fujimoto²,

Kato³

et al. 2012

Dermatology

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A 69-year-old Japanese woman with multiple brain metastases secondary to non-small-cell lung cancer was treated with radiosurgery, and subsequently started oral gefitinib. Three years later, she presented with erythematous erosive alopecia with pustules on the scalp. A biopsy specimen showed a dense perifollicular infiltration composed of lymphocytes, neutrophils and abundant plasma cells. Methicillin-resistant Staphylococcus aureus was cultured from the lesions; however, treatment with antibiotics was not effective. We diagnosed an eruption resembling erosive pustular dermatosis of the scalp. Although oral steroids did not improve the lesions, the pustules and erythema of the scalp rapidly improved within a few weeks after discontinuation of gefitinib. There have been only 11 case reports of alopecia associated with epidermal growth factor receptor (EGFR) inhibitors including our case. It is noteworthy that all cases were female, and most cases involved the parietal scalp. Moreover, the reduction or discontinuation of the EGFR inhibitors was needed in all cases with erythematous alopecia, which remained as scarring alopecia.

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Section: Discussionmentioning

confidence: 83%

“…There have been only 11 case reports of alopecia associated with EGFR inhibitors including our case [8,9,12,14,15,16,17,18,19,20]. We reviewed all case reports (table 1).…”

Section: Discussionmentioning

confidence: 99%

Erosive Pustular Dermatosis of the Scalp-Like Eruption due to Gefitinib: Case Report and Review of the Literature of Alopecia Associated with EGFR Inhibitors

Toda

Fujimoto²,

Kato³

et al. 2012

Dermatology

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“…Immunofluorescence (IF) is characteristic for the presence of the 3 classes of immunoglobulins (IgG, IgM, IgA) and classic and alternative complement pathway deposits (C3, C4, C1q) [1,7,16,[18][19][20] . Because of the widespread potential derangements, a renal biopsy is critical to making the clinical diagnosis, as the pattern of LN injury identified often dictates treatment course and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy: A Case Report and Review of the Literature

Simmons¹,

Smith²,

Chang-Miller

et al. 2015

Am J Nephrol

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Lupus nephritis (LN) is a serious and common complication of systemic lupus erythematosus (SLE) that predisposes to significant morbidity and mortality. Studies show that prompt diagnosis and treatment improves patient survival. We present a case of a 49-year-old female with an atypical presentation of LN who initially presented with new-onset hypertension, edema, arthritis, serositis and recently diagnosed leukocytoclastic vasculitis who later developed acute kidney injury, hematuria and nephrotic syndrome. Laboratory testing showed mixed cryoglobulinemia and elevated perinuclear anti-neutrophil cytoplasmic (p-ANCA) and myeloperoxidase (MPO) antibodies. SLE-related serologies were negative. Kidney biopsy showed diffuse proliferative global glomerulonephritis with a full-house nephropathy pattern on immunofluorescence suggestive of LN. Due to high clinical suspicion and renal biopsy findings, she was treated for LN with prompt renal response to immunosuppression. Cryoglobulins, p-ANCA and MPO titers normalized and the negative SLE serologies remained negative. Literature review on antinuclear antibody (ANA)-negative and seronegative LN revealed the following patient presentations: (1) renal-limited or renal and extra-renal manifestations of SLE with negative serologies and (2) renal and extra-renal manifestations of SLE with negative serologies at presentation who develop positive serologies later in follow-up. Both groups represent a unique and challenging cohort of patients who may require longer follow-up and further testing to rule out other glomerular diseases that may mimic LN on renal biopsy. The absence of SLE-related serologies should be weighed against a high pre-test probability of ANA-negative or seronegative LN. If highly suspected, the patient should be treated promptly with close monitoring.

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The Difficult Dermatologic Condition

Trüeb

2015

The Difficult Hair Loss Patient

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Serum soluble nucleosome and the broad family of antinucleosome antibodies are associated with organ and tissue damage in systemic lupus erythematosus in a Chinese population

Cited by 11 publications

References 8 publications

Erosive Pustular Dermatosis of the Scalp-Like Eruption due to Gefitinib: Case Report and Review of the Literature of Alopecia Associated with EGFR Inhibitors

Erosive Pustular Dermatosis of the Scalp-Like Eruption due to Gefitinib: Case Report and Review of the Literature of Alopecia Associated with EGFR Inhibitors

Antinuclear Antibody-Negative Lupus Nephritis with Full House Nephropathy: A Case Report and Review of the Literature

The Difficult Dermatologic Condition

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