Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Procalcitonin Can Reflect Sepsis Severity and Predict Prognosis: A Prospective Cohort Study

Li, Zhenyu; Wang, Hongxia; Liu, Jian; Chen, Bing; Li, Guangping

doi:10.1155/2014/641039

Cited by 45 publications

(44 citation statements)

References 26 publications

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“…Five cytokines, RANTES, EGF, VEGF R3, MIP-1δ, and LAP, showed significant and consistent differences between the two groups and were selected for further analysis. Changes in the MCP-1 and IL-6 expression levels were opposite but obviously different between the two groups, consistent with previous reports (Mera et al 2011;Li et al 2014), which demonstrated the value of MCP-1 and IL-6 levels in predicting mortality for patients with sepsis. Therefore, we researched these two cytokines, in addition to the five cytokines mentioned above.…”

Section: Screening Of Plasma Samplessupporting

confidence: 92%

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Zhu

Liao

Feng

et al. 2017

Tohoku J. Exp. Med.

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Sepsis is a systemic host response to infection, and patients with sepsis are frequently handled in the intensive care unit. However, mortality related to sepsis remains high throughout the world. In addition, there have been no efficient prognostic biomarkers for sepsis to be employed in clinical practice. We therefore aimed to identify prognostic biomarkers for sepsis using the chemokine/cytokine array. This study included 143 patients with sepsis, who were divided into survivor and nonsurvivor groups according to their 28-day mortality status. The cytokine array analysis was performed with plasma samples from two randomly selected patients in each sepsiofgroup. We thus identified seven cytokines with significantly and consistently different expression levels between nonsurvivors and survivors. The validity of the selected cytokines was then assessed by enzyme-linked immunosorbent assay (ELISA). We finally found monocyte chemoattractant protein 1 (MCP-1) as the most useful biomarker to distinguish the two sepsis groups; namely, non-surviving patients (n = 56) exhibited significantly higher plasma concentrations of MCP-1 compared to survivors (n = 87). MCP-1 is a CC chemokine, a potent chemoattractant that contributes to systemic inflammatory response syndrome. Areas under the receiver operating characteristic curves for prediction of 28-day mortality were 0.763 for MCP-1, 0.680 for the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) score, 0.64 for the Sequential Organ Failure Assessment (SOFA) score, 0.621 for procalcitonin, and 0.785 for MCP-1 plus APACHE II score. In conclusion, we propose that plasma MCP-1 is a useful biomarker in predicting outcome of sepsis.

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Section: Screening Of Plasma Samplessupporting

confidence: 92%

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Zhu

Liao

Feng

et al. 2017

Tohoku J. Exp. Med.

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“…Especially appealing was the assessment of sTREM-1, because it was the only molecule significantly correlated with both the SOFA and APACHE II scores. This is a previously demonstrated finding; effectively, serum sTREM-1 levels are significantly different in patients with sepsis compared to those with severe sepsis/septic shock [35–37] and these levels were correlated with the SOFA score [38]. Moreover, a correlation between sepsis severity and serum levels of IL-6 [39] and PCT [23,37,40–42] had been observed previously.…”

Section: Discussionsupporting

confidence: 78%

Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock

Ríos-Toro¹,

Márquez-Coello

García-Álvarez³

et al. 2017

PLoS ONE

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BackgroundThe objective of this study was to explore the diagnostic and prognostic value of soluble triggering receptor expressed on myeloid cell 1 (sTREM-1), soluble cluster of differentiation 14 (sCD14), soluble cluster of differentiation 163 (sCD163), interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) serum levels for patients with severe sepsis and septic shock in an intensive care unit (ICU).MethodsFifty patients admitted at the ICU with the diagnosis of severe sepsis or septic shock were studied. SOFA and APACHE II scores as well as serum biomarkers were measured at days 0, 2 and 5. The influence of these variables on 28-day mortality was analyzed. Twenty healthy individuals served as controls.ResultsBaseline serum concentrations of sTREM-1, sCD163, IL-6 and PCT correlated with SOFA score. Only sTREM-1 levels correlated with APACHE II score. The 28-day mortality rate for all patients was 42%. The absence of risk factors for infection, presence of septic shock, baseline values of sCD14 and decrease of PCT and IL-6 from baseline to day 5 were variables associated to mortality in the univariate analysis. The unique independent factor associated to mortality in the multivariate analysis was a decrease of PCT higher than 50% from days 0 to 5.ConclusionsSerum levels of sTREM-1 are correlated with the severity of sepsis. A 50% decrease of PCT was the unique variable associated with survival in the multivariate analysis.

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“…(27,28,30,31,32) These studies indicate that serial PCT measurements are considered a possible marker of prognosis.…”

Section: Introductionmentioning

confidence: 94%

Use of biomarkers in pediatric sepsis: literature review

Lanziotti

Póvoa

Soares

et al. 2016

Revista Brasileira De Terapia Intensiva

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Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin. Assessment of these biomarkers may be useful in the management of pediatric sepsis.

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Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Procalcitonin Can Reflect Sepsis Severity and Predict Prognosis: A Prospective Cohort Study

Cited by 45 publications

References 26 publications

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Soluble membrane receptors, interleukin 6, procalcitonin and C reactive protein as prognostic markers in patients with severe sepsis and septic shock

Use of biomarkers in pediatric sepsis: literature review

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