Serum steroid levels in children at birth and in early neonatal period

Kojima, S.; Yanaihara, Takumi; Nakayama, Tomohiro

doi:10.1016/0002-9378(81)90092-2

Cited by 30 publications

(15 citation statements)

References 12 publications

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“…Despite the high ACTH concentrations to be measured in the neonates immediately postpartum, their plasma cortisol levels are comparatively low [8,9], and this in face of the observation that the human fetus at term secretes about 75% of its circulating cortisol and the maternal contribution is about 25% [1]. Plasma cortisol levels depend on the rate of secretion, biotransformation and removal.…”

Section: Discussionmentioning

confidence: 99%

Plasma immunoreactive beta-endorphin, ACTH and cortisol concentrations in mothers and their neonates immediately after delivery — their relationship to the duration of labor

Bacigalupo¹,

Langner²,

Schmidt³

et al. 1987

Journal of Perinatal Medicine

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Section: Discussionmentioning

confidence: 99%

Plasma immunoreactive beta-endorphin, ACTH and cortisol concentrations in mothers and their neonates immediately after delivery — their relationship to the duration of labor

Bacigalupo¹,

Langner²,

Schmidt³

et al. 1987

Journal of Perinatal Medicine

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“…DHEA-S exists at high density in the fetal and neonatal periods (France, 1971;Kojima et al, 1981), and plays an important role in the maintenance of pregnancy and the growth of the fetus (Schuetz and Guzelian, 1993). Since DHEA-S activates CYP3A7-mediated CBZ 10,11-epoxidation, there is a possibility that DHEA-S affects drugmetabolism in fetuses and neonates period in vivo.…”

Section: Kinetic Parameters Of Dhea-s 16␣-hydroxylation By Expressed mentioning

confidence: 99%

CYP3A4 and CYP3A7-Mediated Carbamazepine 10,11-Epoxidation Are Activated by Differential Endogenous Steroids

et al. 2003

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This article is available online at http://dmd.aspetjournals.org ABSTRACT:Recently, we reported that several endogenous steroids affect CYP3A4-mediated drug metabolism, using human adult liver microsomes as an enzyme source. Especially, carbamazepine (CBZ) 10,11-epoxidation is activated by androstenedione (AND). In the present studies, we investigated the effects of endogenous steroids on the activity of CBZ 10,11-epoxidation by expressed CYP3A4 and CYP3A7. When expressed CYP3A4 was used as an enzyme source, the addition of AND to the reaction mixture also caused a drastic increase in the activity of CBZ 10,11-epoxidase, and resulted in a change in the kinetics from sigmoid to MichaelisMenten type. On the other hand, expressed CYP3A7-mediated CBZ 10,11-epoxidation was activated by sulfate conjugate steroids, such as pregnenolone 3-sulfate, 17␣-hydroxypregnenolone 3-sulfate, and dehydroepiandrosterone 3-sulfate (DHEA-S), whereas the unconjugated form corresponding to these three steroids did not activate the reaction. Especially, DHEA-S was found to be a potent activator of CBZ 10,11-epoxidation by expressed CYP3A7. The kinetic character of CBZ 10,11-epoxidation by CYP3A7 is Michaelis-Menten type regardless of the presence of DHEA-S. The presence of DHEA-S caused a decrease in K m and increase in V max for CYP3A7-mediated CBZ 10,11-epoxidation, whereas DHEA-S 16␣-hydroxylation was not affected by the coexistence of CBZ. In conclusion, CYP3A4 and CYP3A7-mediated CBZ 10,11-epoxidations are activated by different types of endogenous steroids. This is the first report regarding CYP3A7 cooperativity.

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“…There is increasing evidence that the adrenal cortex plays an important role in the postnatal adaptation of newborns (1). For full-term healthy infants, data on plasma steroid levels in the neonatal period are available (2,3), but studies on adrenal steroids in healthy premature infants are still lacking. Our micromethod of multisteroid analysis (4,5) enabled us to measure simultaneously in a single small plasma sample individual mineralocorticoids, glucocorticoids, and progestins in premature infants at birth and longitudinally during the first hours and days of life.…”

Section: P Progesterone 170hp 17-hydroxyprogesteronementioning

confidence: 99%

Plasma Mineralocorticoids, Glucocorticoids, and Progestins in Premature Infants: Longitudinal Study during the First Week of Life

et al. 1988

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ABSTRACT. Plasma levels of aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyproge.sterone, 11-deoxycortisol, cortisol, and cortisone were measured simultaneously by a micromethod of multisteroid analysis in eight vaginally delivered premature infants (PI) of 33-36 wk gestation with uneventful peri-and postnatal course. Mean concentrations (nglml) in umbilical arterial and in peripheral venous or capillary plasma sampled longitudinally at age 2 h to 7 days were compared with the same kind of data obtained from a group of 12 term infants (TI) who served as controls. Mean aldosterone was two to five times higher in PI than in TI (umbilical artery, 2 h to 7 days; p < 0.05), whereas 11-deoxycorticosterone was lower in PI from 2 h ( p < 0.01) until 7 days (NS).Corticosterone was significantly higher in PI than TI at 6 and 24 h after birth, whereas cortisol was slightly lower (NS) in PI in umbilical artery and 2 h after birth, but higher (p c 0.02) at 6 h, showing less variation in PI than in TI. 17-Hydroxyprogesterone levels in PI were two to three times higher ( p c 0.02) during 6 h until 7 days after birth. The data suggest that PI are able to maintain high aldosterone levels in the early neonatal period. Higher levels of the active glucocorticoids (cortisol and corticosterone) seen after delivery point to a more stressful extrauterine adaptation of PI. Furthermore, the data demonstrate that the adrenal cortex is fully functioning in premature infants (33-36 wk gestation) as well as in term infants. (Pediatr Res 23: 525-529,1988) Abbreviations RDS, respiratory distress syndrome UA, umbilical artery Aldo, aldosterone DOC, 11-deoxycorticosterone E, cortisone S, 11-deoxycortisol B, corticosterone F, cortisol P. progesterone 170HP, 17-hydroxyprogesterone Abrupt cessation of steroid supply from the placenta after severing the umbilical cord, and rapid postnatal involution of the fetal zone of the adrenal cortex dramatically changes the hormonal milieu of the fetus after birth. There is increasing evidence that the adrenal cortex plays an important role in the postnatal adaptation of newborns (1). For full-term healthy infants, data on plasma steroid levels in the neonatal period are available (2, 3), but studies on adrenal steroids in healthy premature infants are still lacking. Our micromethod of multisteroid analysis (4, 5) enabled us to measure simultaneously in a single small plasma sample individual mineralocorticoids, glucocorticoids, and progestins in premature infants at birth and longitudinally during the first hours and days of life.Herein we assess in detail the adrenocortical function of healthy moderately premature infants after birth and provide reference data for the physiologically most important corticosteroids. MATERIALS AND METHODSEight premature appropriate for gestational age infants (33-36 wk gestation) of both sexes (three males, five females) with uneventful peri-and postnatal courses were studied longitudinally from birth to day 7. Their mothers (20-36 yr) were heal...

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Serum steroid levels in children at birth and in early neonatal period

Cited by 30 publications

References 12 publications

Plasma immunoreactive beta-endorphin, ACTH and cortisol concentrations in mothers and their neonates immediately after delivery — their relationship to the duration of labor

Plasma immunoreactive beta-endorphin, ACTH and cortisol concentrations in mothers and their neonates immediately after delivery — their relationship to the duration of labor

CYP3A4 and CYP3A7-Mediated Carbamazepine 10,11-Epoxidation Are Activated by Differential Endogenous Steroids

Plasma Mineralocorticoids, Glucocorticoids, and Progestins in Premature Infants: Longitudinal Study during the First Week of Life

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