Serum steroid metabolome on the day of oocyte retrieval in women with polycystic ovarian syndrome and its association with pregnancy outcome of in vitro fertilization

Zhu, K. J.; Chen, Yunwen; Sang, Yimiao; Chen, Qingqing; Wang, Guiquan; Zhu, Bo; Lin, Tingting; Mao, Luna; Zhu, Yu

doi:10.1016/j.jsbmb.2023.106311

Cited by 3 publications

(1 citation statement)

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“…It can enhance our comprehension of the downstream metabolic alterations instigated by post-transcriptional regulation, thereby pinpointing the final stage in a series of modifications triggered by external stimuli 12 . Recent studies have shown that oocyte and gonadal development is strictly modulated by an intricate network of metabolic 13 – 15 . Consequently, the integration of whole-genome sequencing technology and metabolomics offers a robust method for studying the intricate and complex interactions between transcriptional regulation and metabolic processes.…”

Section: Background and Summarymentioning

confidence: 99%

Transcriptomic and metabolomic data of goat ovarian and uterine tissues during sexual maturation

Wang,

et al. 2024

Sci Data

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The ovaries and uterus are crucial reproductive organs in mammals, and their coordinated development ensures the normal development of sexual maturity and reproductive capacity. This study aimed to comprehensively capture the different physiological stages of the goat’s sexual maturation by selecting four specific time points. We collected samples of ovarian and uterine tissues from five female Jining Gray goats at each time point: after birth (D1), 2-month-old (M2), 4-month-old (M4), and 6-month-old (M6). By combining transcriptomic sequencing of 40 samples (including rRNA-depleted RNA-seq libraries with 3607.8 million reads and miRNA-seq libraries with 444.0 million reads) and metabolomics analysis, we investigated the transcriptomic mechanisms involved in reproductive regulation in the ovary and uterus during sexual maturation, as well as the changes in metabolites and their functional potential. Additionally, we analyzed blood hormone indices and uterine tissue sections to examine temporal changes. These datasets will provide a valuable reference for the reproductive regulation of the ovary and uterus, as well as the regulation of metabolites during sexual maturation in goats.

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Section: Background and Summarymentioning

confidence: 99%