Serum, synovial and mRNA expression of interleukin-33 in juvenile idiopathic arthritis patients: Potential role as a marker of disease activity and relation to musculoskeletal ultrasound

Noor-eldeen, Enas; Hassan, Waleed; Behiry, Eman G.; El-monem, Abd El-hameed Abd

doi:10.1016/j.ejr.2020.02.005

Cited by 2 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-33 serum levels were significantly higher in polyarticular patients compared to oligoarticular and systemic onset. This is in agreement with another recent study [15]. This is in the same line with Matsuyama et al…”

Section: Currentsupporting

confidence: 94%

Serum level of Interleukin-33 and relation to disease activity in Juvenile Idiopathic Arthritis

Zeid

Eltoraby

Abdel-Salam

et al. 2022

Mansoura Medical Journal

View full text Add to dashboard Cite

The pathogenesis of juvenile idiopathic arthritis (JIA) is not fully understood. So, this study was conducted to investigate the clinical usefulness of serum IL-33 levels as an indicator of the disease activity in JIA. Methods. This cross-sectional study was conducted on 45 JIA patients. All patients were subjected to detailed history taking, complete clinical examination with emphasis on pattern and distribution of articular and extra-articular involvement. Disease activity score (DAS28) was assessed. Venous blood (10 ml) was collected to assess routine laboratory investigations in addition to IL-33. Results . Most of patients had sudden arthritis onset (64.4%) and (95.6%) had progressive course. 6 patients (13.3%) of patients had oligoarticular arthritis, 17 patients (37.8%) had polyarticular arthritis and 22 patients (48.9%) had systemic arthritis. 88.9% had emotional aggravation factor, while 86.7% had medication and movement as relieving factors. Only 8.9% of patients' diseases are controlled, 46.7% had relapse, and 6.7% stopped treatment. 66.7% of patients had good response and 33.3% had poor response. JIA patients had a significantly higher serum IL-33 levels compared to IL-33 serum in the control group (p=0.008). There was significant positive correlation between IL-33 with duration of disease (p=0.002, r=0.612), DAS28CRP (p<0.001, r=0.705) and DAS28_ESR (p=0.001, r=0.667), However, serum IL-33 levels did not significantly correlate with the levels of serum CRP or ESR. Conclusions. JIA patients have significantly elevated IL-33 serum concentrations and that considerably correlated with clinical, laboratory and activity parameters of disease suggesting that it could be a valuable marker of JIA disease activity.

show abstract

Section: Currentsupporting

confidence: 94%