Serum Tamm-Horsfall Protein Levels in Childhood: Relationship with Age and Glomerular Filtration Rate

Al-Faham, Manar S A; Meyrick, Simon; Avis, P.; Jones, Karen

doi:10.1159/000185645

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…These levels were consistent with those reported by Avis [5] and Dawnay and C'attell [12]. Alfaham et al [13] re cently reported that serum THGP levels were lowered, especially in younger infants. In our study, there was no significant relationship between serum THGP levels and age.…”

Section: Discussionsupporting

confidence: 90%

Serum Tamm-Horsfall Glycoprotein Level in Children with Various Renal Diseases

Yamamoto

Miyata

et al. 1991

Nephron

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Serum Tamm-Horsfall glycoprotein (THGP) concentrations were measured by a competitive enzyme-linked immunosorbent assay using peroxidase-labeled THGP in 168 patients, aged 10.5 ± 4.6 years, with various renal diseases. Using this method, THGP was determined in the concentration range of 10-10³ μg/l. Serum THGP levels ranged from 130 to 350 μg/l in 32 control subjects, aged 1–16 years with normal renal function. In most patients with renal disease, the serum THGP levels were lower than those in control subjects. In particular, the serum THGP levels were more reduced according to the decrease in the clearance values of endogenous creatinine (CCR). These findings suggested that the measurement of serum THGP levels is helpful in the evaluation of renal function. On the other hand, 3 patients with vesicoureteric reflux showed higher serum THGP levels than control subjects, though the CCR values in 1 of these patients was lower. These high serum THGP levels may be the result of urinary backflow into circulation.

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Section: Discussionsupporting

confidence: 90%

Serum Tamm-Horsfall Glycoprotein Level in Children with Various Renal Diseases

Yamamoto

Miyata

et al. 1991

Nephron

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“…Therefore, an absolute increase in Scr might vary substantially in children and was not suitable for diagnosing AKI in younger ages [ 47 ]. The serum UMOD levels also increased significantly during growth [ 48 ], but with the elucidated subgroup difference in different age groups. Therefore, uUMOD is more valuable and helpful to predict AKI of children, as well as a more easy to accessible and non-invasive process than serum UMOD for children.…”

Section: Discussionmentioning

confidence: 99%

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis

You

Zheng

et al. 2021

j intensive care

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Background Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI. However, currently available publications showed inconsistent results. We designed this meta-analysis to evaluate the potential association between uUMOD and AKI. Methods We searched research articles with no language restriction in Medline, Web of Science, Cochrane Library, Embase, and 3 Chinese datasets from inception to February 2021. We used random-effects models to estimate the standardized mean difference (SMD) between patients with AKI or not, while the leave-one-out method and random-effects meta-regression to evaluate the sensitivity and the impact of potential confounders such as age and surgery. Results The meta-analysis comprising 3148 subjects from 11 studies showed that the uUMOD of the AKI group is significantly lower than the non-AKI group (SMD: − 0.71; 95% confidence interval (CI), − 1.00, − 0.42, P < 0. 001, I2 = 78.8%). Subgroup analysis revealed the difference is also significant in a different age, surgery condition, and assay time but not acute rejection (AR) group, especially in children (SMD: − 1.21, 95% CI: − 1.80, − 0.61; P < 0.001) and patients undergoing surgery (SMD: − 1.03, 95% CI: − 1.75, − 0.30; P < 0.001). Lower uromodulin is associated with higher odds for AKI incidence (odds ratio = 2.47, 95% CI: 1.12, 5.47; P < 0.001, I2 = 89%). Meta-reggression found that age was associated with the SMD of uUMOD. The study outcome was reliably confirmed by the sensitivity analysis. Conclusion The present study suggested a negative association between uUMOD and AKI especially in children and surgical patients.

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“…Both indirect as well as direct ELISA setups have been reported for urinary [5,[97][98][99][100][101] and serum [91,102,103] measurements. In the 1990s, Syn elisa THP immunoassay was available from Elias Medizintechnik GmbH (Freiburg, Germany; which later became Elias/Pharmacia & Upjohn), but its production was eventually discontinued.…”

Section: Biochemical Analysismentioning

confidence: 99%

Uromodulin Biology and Pathophysiology – An Update

Vyleťal

Bleyer

Kmoch

2010

Kidney Blood Press Res

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Uromodulin (UMOD) is a glycoprotein expressed on the luminal surface of the apical membrane of renal tubular epithelial cells forming the thick ascending limb of Henle. Here, UMOD forms filamentous structures probably ensuring water impermeability and the countercurrent gradient. The multidomain structure, cellular topology of UMOD and clinical consequences associated with UMOD dysfunction, however, suggest that it may be involved in other biological processes such as receptor-mediated endocytosis, mechanosensation of urinary flow, Wnt-signaling, cell cycle regulation and planar cell polarity. A specific, but as yet unidentified, protease(s) releases UMOD into the urine, where it probably contributes to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals. UMOD expression, biosynthesis and excretion are regulated in a complex manner, and dysregulation is found in a wide range of pathological conditions. It is strongly reduced or absent in cases with mutations in UMOD, renin, HNF1B and other genetic disorders causing autosomal dominant hyperuricemic nephropathy. In contrast, elevated UMOD excretion may be associated with, and thus predictive of, chronic kidney disease. UMOD analysis is therefore of importance in all conditions with renal involvement and may be useful in the proper classification of renal diseases.

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Serum Tamm-Horsfall Protein Levels in Childhood: Relationship with Age and Glomerular Filtration Rate

Cited by 7 publications

References 11 publications

Serum Tamm-Horsfall Glycoprotein Level in Children with Various Renal Diseases

Serum Tamm-Horsfall Glycoprotein Level in Children with Various Renal Diseases

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis

Uromodulin Biology and Pathophysiology – An Update

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