Serum tau as a predictor for neurological outcome after cardiopulmonary resuscitation

Haßlacher, Julia; Rass, Verena; Beer, Ronny; Ulmer, Hanno; Humpel, Christian; Schiefecker, Alois Josef; Lehner, Georg; Bellmann, Romuald; Joannidis, Michael; Helbok, Raimund

doi:10.1016/j.resuscitation.2020.01.022

Cited by 3 publications

(2 citation statements)

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“…Medical decision making followed a rigorous protocol. Beside the gold standard serum NSE, SN and Tau protein have proved to be reliable predictors of poor neurological outcome [ 30 , 34 ]. In none of the biomarkers was the predictive value affected by sex suggesting that biomarkers can be equally applied to men and women.…”

Section: Discussionmentioning

confidence: 99%

“…Blood samples were drawn from the arterial catheter at the day of CPR up to 7 days and assigned to following time intervals: 0–24 h (day 0), 24–48 h (day 1), 48–72 h (day 2), 72–96 h (day 3), 96–120 h (day 4), 120–144 h (day 5), 144–168 h (day 6). We determined serum neuron-specific enolase (NSE) as a gold standard for neuroprognostication [ 33 ], secretoneurin (SN) as early biomarker [ 30 ] and serum tau as a marker for axonal damage [ 34 ]. The SN measurements were performed with a radioimmunoassay according to Kirchmair et al.…”

Section: Patients Materials and Methodsmentioning

confidence: 99%

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Postresuscitation care and prognostication after cardiac arrest—Does sex matter?

Haßlacher

Ulmer

Lehner

et al. 2022

Wien Klin Wochenschr

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Summary Background There are conflicting results concerning sex-specific differences in the post-cardiac arrest period. We investigated the sex distribution of patients after successful cardiopulmonary resuscitation (CPR), differences in treatment, complications, outcome and sex-specific performance of biomarkers for prognostication of neurological outcome. Methods Prospective observational study including cardiac-arrest (CA) patients treated with mild therapeutic hypothermia (MTH) at 33 °C for 24 h or normothermia. We investigated common complications including pneumonia and acute kidney injury (AKI) and neuron-specific enolase, secretoneurin and tau protein as biomarkers of neurological outcome, which was assessed with the cerebral performance categories score at hospital discharge. Results Out of 134 patients 26% were female. Women were significantly older (73 years, interquartile range (IQR) 56–79 years vs. 62 years, IQR 53–70 years; p = 0.038), whereas men showed a significantly higher rate of pneumonia (29% vs. 6%; p = 0.004) and a trend towards higher rates of AKI (62% vs. 45%; p = 0.091). Frequency of MTH treatment was not significantly different (48% vs. 31%; p = 0.081). Female sex was not associated with neurological outcome in multivariable analysis (p = 0.524). There was no significant interaction of sex with prognostication of neurological outcome at 24, 48 and 72 h after CPR. At the respective time intervals pinteraction for neuron-specific enolase was 0.524, 0.221 and 0.519, for secretoneurin 0.893, 0.573 and 0.545 and for tau protein 0.270, 0.635, and 0.110. Conclusion The proportion of female patients was low. Women presented with higher age but had fewer complications during the post-CA period. Female sex was not associated with better neurological outcome. The performance of biomarkers is not affected by sex.

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Section: Discussionmentioning

confidence: 99%