Serum Testosterone, LH, and FSH in Patients with Testicular Cancer Before and After Radio- and Chemotherapy

Jg, Berthelsen; Sa, Engelholm; H, von der Maase; Rørth, Mikael

doi:10.3109/00365598309182133

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…After unilateral orchidectomy, decreased testosterone levels were found in 5‐34% of patients, probably due to preexisting abnormalities in the remaining testicle 28‐31. However, normal sexual functioning is possible even with very low serum testosterone levels (6‐12 nmol/L),32, 33 and it has been shown that erection can still occur even after castration 34, 35.…”

Section: Treatment‐related Biologic‐organic Influences On Sexual Funcmentioning

confidence: 99%

Sexual functioning after treatment for testicular cancer

Jonker-Pool¹,

Basten²,

Hoekstra³

et al. 1997

Cancer

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Medical information was obtained from the patient records. been treated with polychemotherapy (PCT) with or without resection of residual retroperitoneal tumor mass (RRRTM) (PCT { RRRTM) reported a significantly 3 Department of Urology, University Hospital Groningen, Groningen, The Netherlands. RESULTS.sharper decrease in sexual functioning than patients who had been followed with a wait-and-see policy (W & S) (Stage I nonseminoma patients). It was noteworthy 4 Department of Medical Oncology, University that patients treated by PCT alone reported more sharply decreased sexual funcHospital Groningen, Groningen, The Netherlands. ing, it appears that psychologic factors arising from the confrontation with testicular cancer play a strongly mediating (if not determining) role.

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Section: Treatment‐related Biologic‐organic Influences On Sexual Funcmentioning

confidence: 99%

Sexual functioning after treatment for testicular cancer

Jonker-Pool¹,

Basten²,

Hoekstra³

et al. 1997

Cancer

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“…Particularly, pregnant ewes with twins or multiple fetuses always encounter undernutrition during late gestation, since feed intake dramatically declines due to the increased volume of uterus and extruded abdomen while the nutrition requirement significantly elevates because of fetal growth and development. Previous studies revealed that undernutrition disrupted metabolic homeostasis and induced serious lipid metabolism disorders in maternal and fetal livers [ 2 – 4 ], which may induce maternal diseases and fetal growth retardation and maldevelopment [ 5 – 7 ]. However, little information is known about the effect of undernutrition on ruminal homeostasis in spite of the fact that ruminal homeostasis is the basis for the metabolism, development, and health of ruminants [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model

Xue

Lin

et al. 2020

Microbiome

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Background Undernutrition is a prevalent and spontaneous condition in animal production which always affects microbiota-host interaction in gastrointestinal tract. However, how undernutrition affects crosstalk homeostasis is largely unknown. Here, we discover how undernutrition affects microbial profiles and subsequently how microbial metabolism affects the signal transduction and tissue renewal in ruminal epithelium, clarifying the detrimental effect of undernutrition on ruminal homeostasis in a pregnant sheep model. Results Sixteen pregnant ewes (115 days of gestation) were randomly and equally assigned to the control (CON) and severe feed restriction (SFR) groups. Ewes on SFR treatment were restricted to a 30% level of ad libitum feed intake while the controls were fed normally. After 15 days, all ewes were slaughtered to collect ruminal digesta for 16S rRNA gene and metagenomic sequencing and ruminal epithelium for transcriptome sequencing. Results showed that SFR diminished the levels of ruminal volatile fatty acids and microbial proteins and repressed the length, width, and surface area of ruminal papillae. The 16S rRNA gene analysis indicated that SFR altered the relative abundance of ruminal bacterial community, showing decreased bacteria about saccharide degradation (Saccharofermentans and Ruminococcus) and propionate genesis (Succiniclasticum) but increased butyrate producers (Pseudobutyrivibrio and Papillibacter). Metagenome analysis displayed that genes related to amino acid metabolism, acetate genesis, and succinate-pathway propionate production were downregulated upon SFR, while genes involved in butyrate and methane genesis and acrylate-pathway propionate production were upregulated. Transcriptome and real-time PCR analysis of ruminal epithelium showed that downregulated collagen synthesis upon SFR lowered extracellular matrix-receptor interaction, inactivated JAK3-STAT2 signaling pathway, and inhibited DNA replication and cell cycle. Conclusions Generally, undernutrition altered rumen bacterial community and function profile to decrease ruminal energy retention, promoted epithelial glucose and fatty acid catabolism to elevate energy supply, and inhibited the proliferation of ruminal epithelial cells. These findings provide the first insight into the systemic microbiota-host interactions that are involved in disrupting the ruminal homeostasis under a malnutrition pattern.

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“…Most of them originated from the treatment of leukaemic infiltrates in the testes of pre-pubertal boys, indicating that a dose of 24 Gy given to this age group may cause irreversible damage to the endocrine function of the testis [24]. In addition, previous data have indicated that not only the spermatogenesis but also the activity of Leydig cells in the contralateral gonad may be impaired [3], making them even more sensitive to harmful effects. After the first patients with CIS had been irradiated, a group from Manchester [43] published their data on irradiation of the contralateral testis of 49 seminoma patients.…”

Section: Radiation Dosementioning

confidence: 99%

Current concepts of radiation treatment of carcinoma in situ of the testis

et al. 1994

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During a recent international workshop on carcinoma in situ and cancer of the testis held in November 1992, there was consensus about the management of the contralateral testis in patients with unilateral testicular cancer [20]. Such men should be offered a biopsy of the contralateral testis. This consensus was based on (1) the high prevalence of carcinoma in situ (CIS) in the contralateral testis found not only in Danish men but also in studies from other countries and (2) the possibility of eradicating the CIS and thereby preventing the development of invasive cancer by means of localized irradiation with preservation of testosterone production in the testis. The aim of this paper is to outline the present status of the radiation treatment of CIS of the testis.

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Serum Testosterone, LH, and FSH in Patients with Testicular Cancer Before and After Radio- and Chemotherapy

Cited by 10 publications

References 9 publications

Sexual functioning after treatment for testicular cancer

Sexual functioning after treatment for testicular cancer

Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model

Current concepts of radiation treatment of carcinoma in situ of the testis

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