Serum theophylline levels with oral sustained release theophylline after transfer from intravenous aminophylline in patients with chronic lung disease [letter]

Silins, R A; Butcher, MA; Marlin, G. E.

doi:10.1111/j.1365-2125.1984.tb02521.x

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Intravenous Administration1

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1988

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Cited by 4 publications

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“…Oral dosing commenced immediately on cessation of the intrave¬ nous aminophylline will enable therapeutic theophylline levels to be maintained without the need for tapering or overlap. 81 Theophylline dose should be slowly titrated upward in stable outpatients with COPD, using clinical indexes and occasional blood levels to guide therapy. To minimize the risk of toxicity, initial daily doses should not exceed 400 mg in nonsmoking adults82 or 600 mg in smokers.…”

Section: Intravenous Administrationmentioning

confidence: 99%