Serum thymus and activation‐regulated chemokine is a surrogate marker for bullous pemphigoid disease activity

Jesus, C S de; Yonekura, Shin Ichiro; Nomura, Takashi; Egawa, Gyohei; Kabashima, Kenji

doi:10.1111/jdv.19145

Acad Dermatol Venereol

2023

DOI: 10.1111/jdv.19145

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Serum thymus and activation‐regulated chemokine is a surrogate marker for bullous pemphigoid disease activity

C S de Jesus

Shin Ichiro Yonekura

Takashi Nomura

et al.

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2024

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Cited by 2 publications

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TARC/CCL17 reflects the severity of pemphigus (pemphigus vulgaris and pemphigus foliaceus) at the initial presentation

Takegami,

Yonekura,

Nomura

et al. 2024

JEADV Clinical Practice

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BackgroundPemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases targeting desmoglein 3 (Dsg3) or desmoglein 1 (Dsg1). The current scoring system, pemphigus disease area index (PDAI), has limitations including inter‐ and intra‐evaluator variability, as well as a time‐consuming evaluation process.ObjectivesTo identify objective and quantitative surrogate markers for assessing disease severity in PV and PF.MethodsEleven PV and PF patients were included. PDAI scores and candidate biomarkers [anti‐Dsg3 antibody, anti‐Dsg1 antibody, thymus and activation‐regulated chemokine (TARC)/CCL17, immunoglobulin E (IgE) levels and eosinophil counts] were measured before oral corticosteroid treatment. Pearson's correlation coefficient was used for correlations between PDAI and candidate biomarkers.ResultsSerum TARC/CCL17 levels significantly correlated with PDAI scores in PV and PF (R = 0.72, p = 0.02), while anti‐Dsg3 antibody levels correlated with PDAI scores for PV (R = 0.86, p = 0.012). No significant correlations were observed for anti‐Dsg1 antibody, eosinophil counts or IgE levels.ConclusionsSerum TARC/CCL17 may be a quantitative and unbiased disease biomarker in pemphigus patients, although further studies involving larger patient cohorts are needed.

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TARC/CCL17 reflects the severity of pemphigus (pemphigus vulgaris and pemphigus foliaceus) at the initial presentation

Takegami,

Yonekura,

Nomura

et al. 2024

JEADV Clinical Practice

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Exploring Pruritus in Bullous Pemphigoid; Analysis of Quality-of-Life Metrics and Potential Biological Mechanisms

Osuoji,

DeGrazia,

Cole

et al. 2024

JID Innovations

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Serum thymus and activation‐regulated chemokine is a surrogate marker for bullous pemphigoid disease activity

Cited by 2 publications

References 9 publications

TARC/CCL17 reflects the severity of pemphigus (pemphigus vulgaris and pemphigus foliaceus) at the initial presentation

TARC/CCL17 reflects the severity of pemphigus (pemphigus vulgaris and pemphigus foliaceus) at the initial presentation

Exploring Pruritus in Bullous Pemphigoid; Analysis of Quality-of-Life Metrics and Potential Biological Mechanisms

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