Serum thymus and activation‐regulated chemokine levels before and after treatment for pruritic scabies

Arakawa, Yukiyasu; Tamagawa‐Mineoka, Risa; Masuda, Kouji; Katoh, Norito

doi:10.1111/jdv.16698

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Lastly, a ligand for CCR4+ Th2 T cells, Thymus and Activation‐Regulated Chemokine (TARC), was increased in scabies lesions compared to healthy skin. A later case report found TARC levels significantly decreased following successful treatment of active scabies 38 . The mechanism of scabies‐associated pruritus is not yet fully understood but recent studies point toward a prominent role of a Th2‐mediated process.…”

Section: The Role Of the Th2 Immune Response In Chronic Pruritic Cond...mentioning

confidence: 99%

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The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

Ingrasci

Lipman

Hawash

et al. 2021

Experimental Dermatology

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While there is a vast array of aetiologies that may lead to chronic pruritus, recent data suggests that many of these conditions share similar interactions between keratinocytes, nerves, and the immune system. Specifically, the type 2 immune response, including Th2 T Cells and their related cytokines, has been noted to play a major role in the development of pruritus in a variety of itchy conditions. To date, atopic dermatitis is the most striking example of this pathogenesis. However, the body of literature supporting its role in many other itchy conditions, including other inflammatory, bullous, as well as systemic diseases, continues to grow. In addition, new treatments targeting this type 2 immune system continue to be developed and investigated. In the current review, we present the current body of literature supporting the role of the type 2 immune response in itchy conditions beyond atopic dermatitis as well as potential therapeutic options that target this pathway for chronic itch.

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Section: The Role Of the Th2 Immune Response In Chronic Pruritic Cond...mentioning

confidence: 99%

“…A later case report found TARC levels significantly decreased following successful treatment of active scabies. 38 The mechanism of scabies-associated pruritus is not yet fully understood but recent studies point toward a prominent role of a Th2-mediated process.…”

Section: Scabiesmentioning

confidence: 99%

The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

Ingrasci

Lipman

Hawash

et al. 2021

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…9 However, TARC levels are not only increased in AD, and thus, they might not discriminate from relevant differential diagnoses such as bullous pemphigoid, scabies, cutaneous T-cell lymphoma, or the lymphocytic variant of hypereosinophilic syndromes. 7,9,12,15 The presence of respiratory allergic disease does not seem to affect serum levels of TARC. 6 Compared with TARC, other markers have been studied less intensively.…”

Section: Admentioning

confidence: 95%

Are blood cytokines reliable biomarkers of allergic disease diagnosis and treatment responses?

Radonjic-Hoesli

Pavlov

Simon

et al. 2022

Journal of Allergy and Clinical Immunology

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Serum thymus and activation‐regulated chemokine levels before and after treatment for pruritic scabies

Cited by 2 publications

References 8 publications

The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

Are blood cytokines reliable biomarkers of allergic disease diagnosis and treatment responses?

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