Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Feldt‐Rasmussen, Ulla

doi:10.1111/j.1398-9995.1983.tb05081.x

Cited by 39 publications

(18 citation statements)

References 109 publications

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“…Controversy exists about the influence of age and gender on serum Tg, as discussed by Feldt-Rasmussen (36,38,39). We found clearly lower levels of serum Tg in men, also after correcting for the difference in thyroid abnormalities.…”

Section: Discussionmentioning

confidence: 52%

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Serum Tg—A Sensitive Marker of Thyroid Abnormalities and Iodine Deficiency in Epidemiological Studies

Knudsen

Bülow

Jørgensen

et al. 2001

The Journal of Clinical Endocrinology & Metabolism

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Serum Tg is widely used in the control of thyroid cancer but also in the diagnosis of certain other thyroid diseases. Serum Tg may be useful in the characterization of the iodine status of a population, but little is known about determinants of serum Tg levels. We examined a random selection of 4,649 subjects from 2 regions in Denmark with different iodine status. Thyroid volume and structure were determined with ultrasonography, and thyroid function tests and Tg analysis were performed. The factor with the closest association with serum Tg levels was thyroid volume at ultrasonography (P < 0.001). Also thyroid nodularity (P < 0.001) and iodine excretion (P < 0.001) had close associations to serum Tg, even after adjusting for the influence of the other parameters. Thyroid dysfunction had a less pronounced but still highly significant association with serum Tg (P < 0.001), but no relation was found to serum TSH in general. The association with age seemed to rely on differences in the prevalence of thyroid abnormalities, and men had lower Tg levels than women of the same age. There was a marked difference in serum Tg between the two regions with slightly different iodine excretion also after adjusting for the other factors. In conclusion, serum Tg reflects thyroid abnormalities and thyroid function and is a sensitive marker of iodine deficiency in a population.

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Section: Discussionmentioning

confidence: 52%

“…It has been shown, in a number of studies, that serum Tg is increased in Graves' disease (36,37). We report an independent association of suppressed TSH values to serum Tg, though the associated increase in thyroid volume and nodules had additional effects.…”

Section: Discussionmentioning

confidence: 57%

Serum Tg—A Sensitive Marker of Thyroid Abnormalities and Iodine Deficiency in Epidemiological Studies

Knudsen

Bülow

Jørgensen

et al. 2001

The Journal of Clinical Endocrinology & Metabolism

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“…Secondly, its detection by Western blot was affected by disruption of disulfide bonds. The polydispersed immunoreactive material, amounting to up to 30%, could correspond to Tg complexed to trace amounts of TgaAb (26)(27)(28). As this immunoreactive material was not precipitated by protein A, these soluble immune complexes might be formed mainly from Ig other than IgG.…”

Section: Figure 4 Identification Of Serum Tg By Western Blot (A)mentioning

confidence: 99%

Analyses of the molecular forms of serum thyroglobulin from patients with Graves' disease, subacute thyroiditis or differentiated thyroid cancer by velocity sedimentation on sucrose gradient and Western blot

Druetta

Croizet²,

Bornet³

et al. 1998

European Journal of Endocrinology

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Serum thyroglobulin (Tg) concentration increases in diverse thyroid pathophysiological situations. We examined whether Tg molecules appearing in the serum of patients with Graves' disease (GD), subacute thyroiditis (ST) or differentiated thyroid cancer (DTC) have distinctive biochemical properties. We used ultracentrifugation on sucrose gradient and Western blot to analyze structural parameters of immunoreactive Tg in complete serum from 40 patients with GD, ST or DTC. Purified human Tg was used as reference.Immunoreactive Tg from ST or DTC sera sedimented in a single, rather symmetrical peak as purified 19S Tg. In GD sera without detectable anti-Tg autoantibodies (TgaAb), about 80% of immunoreactive Tg was recovered in a Tg dimer peak that often split into two components; the remaining Tg immunoreactivity (10-30%) sedimented faster and was polydispersed. In GD sera containing TgaAb, immunoreactive Tg was recovered in a peak sedimenting faster than 19S Tg corresponding to immune complexes identified by protein A adsorption. Using a Western blot procedure, optimized to detect 0.1 ng Tg in serum, a single band of Tg, migrating as the intact Tg subunit, was always found in nonreducing conditions; the intensity of the band correlated with the immunoassayable Tg concentration. In reducing conditions, the Tg band obtained with GD or ST sera was decreased by up to 70% compared with that of purified Tg or serum Tg from patients with DTC.In conclusion, serum Tg from DTC is remarkably homogeneous and in the form of dimers dissociable into uncleaved monomers. In contrast, serum Tg from GD or ST is heterogeneous with respect to its sedimentation properties and/or the structural integrity of its polypeptide chains. These data provide information on the processes whereby Tg is released into the circulation.

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“…The normal 24 h creatinine excretion for people of the same sex and age used for calculation ('24 h Cr norm') were the average values taken from a population study. The data are from reference 19. hormone secretion will lead to an increase in the serum concentration of Tg 27 . During a normal pregnancy, there is a considerable increase in requirements for thyroid hormone and therefore also in thyroid secretory activity 28 .…”

Section: An Increase In the Serum Concentration Of Tg During Pregnancmentioning

confidence: 99%

Evaluating iodine deficiency in pregnant women and young infants—complex physiology with a risk of misinterpretation

Laurberg

Andersen

Bjarnadóttir

et al. 2007

Public Health Nutr.

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Objective: To review methods for evaluating iodine deficiency in pregnant women and young infants and to discuss factors to be considered in the interpretation of their results. Design: Review of the literature regarding the various methods available for assessing iodine status. Setting: Population surveys and research studies. Subjects: Pregnant women and young infants. Results: Several factors to consider when assessing iodine status in pregnant women and young infants include: 1) the urinary iodine (UI) concentration (mg l -1 ) is not interchangeable with 24 h UI excretion (mg per 24 h); 2) the concentration of iodine in a spot or casual urine sample cannot be used to diagnose iodine deficiency in an individual; 3) a moderate fall in the concentration of serum free T4 during pregnancy is not a sign of maternal iodine deficiency; 4) an increase in the concentration of serum thyroglobulin (Tg) during pregnancy is not a sign of maternal iodine deficiency; 5) a higher concentration of TSH and Tg in cord blood than in maternal blood is not a sign of iodine deficiency in the mother or neonate; and 6) thyroid function in a full-term foetus, a neonate or a small child is not more sensitive to a mild iodine deficiency than in the mother. Conclusions: If the iodine status of pregnant women and small children is not to be misjudged, the above six factors need to be taken into account.

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Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Cited by 39 publications

References 109 publications

Serum Tg—A Sensitive Marker of Thyroid Abnormalities and Iodine Deficiency in Epidemiological Studies

Serum Tg—A Sensitive Marker of Thyroid Abnormalities and Iodine Deficiency in Epidemiological Studies

Analyses of the molecular forms of serum thyroglobulin from patients with Graves' disease, subacute thyroiditis or differentiated thyroid cancer by velocity sedimentation on sucrose gradient and Western blot

Evaluating iodine deficiency in pregnant women and young infants—complex physiology with a risk of misinterpretation

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