Serum Thyroid Hormone Levels in Liver Diseases with Special

Yamanaka, Takeo; Ido, Kenichi; Kimura, Ken; Saitoh, Toshikazu; Nagai, Fusako

doi:10.2957/kanzo.19.951

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Hepatically Impaired Patients1

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2010

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“…Other authors have not shown significant reduction in T 3 concentrations in patients with different degrees of liver impairment except when patients had severe cirrhosis. 60 The clinical impact of severe cirrhosis on thyroid hormone levels is also influenced by other factors, such as lower levels of thyroxine binding proteins such as albumin. Overall, this possibly leads to an increase in free T 4 concentrations or the ratio of free T 3 to bound T 3 , meaning that despite overall lower levels of T 3 , more free T 4 and T 3 is available.…”

Section: Hepatically Impaired Patientsmentioning

confidence: 99%

A Review of the Pharmacokinetics of Levothyroxine for the Treatment of Hypothyroidism

Colucci¹,

Yue²,

Ducharme³

et al. 2010

European Endocrinology

133

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Thyroxine hormone has been recognised since the early part of the nineteenth century and levothyroxine has been available since the mid-nineteenth century as a replacement for deficient thyroid hormones. While levothyroxine remains the staple treatment for hypothyroidism even to this day, its optimal use can be challenging. As is often the case with older drugs, the pharmacokinetics of levothyroxine is often under-appreciated or misunderstood and many factors influence the optimal dosing of levothyroxine. This article will review the pharmacokinetics of levothyroxine in the treatment of hypothyroidism and highlight major concepts that should aid both clinicians and researchers.

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Section: Hepatically Impaired Patientsmentioning

confidence: 99%