Serum Thyroid Stimulating Hormone Levels Are Associated with the Presence of Coronary Atherosclerosis in Healthy Postmenopausal Women

Abstract

ObjectivesMenopause is a natural aging process causing estrogen deficiency, accelerating atherogenic processes including dyslipidemia. Prevalence of thyroid dysfunction is also high in postmenopausal women, and it is known to elevate the risk of cardiovascular disease (CVD). Therefore, we are to study on the associations in between serum thyroid stimulating hormone (TSH) and prevalence of CVD in postmenopausal women who have normal thyroid function.MethodsWe performed a retrospective review of 247 Korean postmenopausal women who visited the health promotion center from January, 2007 to December, 2009. Postmenopausal women with normal serum TSH were included in the study. Coronary atherosclerosis was assessed by 64-row multidetector computed tomography.ResultsIn multiple linear regression analysis, serum TSH was associated with serum triglyceride (TG) (β = 0.146, P = 0.023). In multiple logistic regression analysis, increasing age and serum TSH were associated with an increased risk of coronary atherosclerosis in euthyroid postmenopausal women (odds ratio [OR] = 1.107 [1.024-1.197], P = 0.011 and OR = 1.303 [1.024-1.658], P = 0.031, respectively).ConclusionsIt revealed that significant predictor of serum TSH was serum TG, and increasing age and TSH were found to have associations with an increased risk of coronary atherosclerosis in euthyroid postmenopausal women. Screening and assessing risks for CVD in healthy postmenopausal women would be helpful before atherosclerosis develops.

Age-related change in thyroid-stimulating hormone: a cross-sectional study in healthy euthyroid population

“…Similarly, positive correlation was also found between TSH and lipid profiles in euthyroid Chinese [30], Spanish [31] and Korean [32]. Our results, in agreement with the findings from the study of Chon et al [33], showed that serum TSH had no relationship with FPG and BMI. Other studies also investigate the relationship between serum TSH and BP in euthyroid population.…”

Serum Follicle-Stimulating Hormone Levels are Associated with Cardiometabolic Risk Factors in Post-Menopausal Korean Women

“…Because estrogen is the primary hormone responsible for CVD in menopausal women [9], we further analyzed the association between estrogen levels and cardiometabolic risk factors. Estradiol Elevation of serum thyroid-stimulating hormone (TSH) is common in post-menopausal women [24], and serum levels of TSH associate positively with cardiometabolic risk factors even in post-menopausal women with normal thyroid function [25,26]. Therefore, we analyzed the association between FSH and cardiometabolic risk factors after adjustment for age, body weight, and TSH.…”

Myocardial Infarction in Women of Reproductive age: Risk Factors, Clinical Picture, Prognosis

“…С учетом данных об увеличении риска развития ССЗ при приеме пероральных контрацептивов в зависимости от длительности их приема [15], поколения препарата [16], а также наличие таких ФР, как курение, АГ, гиперлипидемия, СД и отягощенная наследственность [17,18], можно считать, что перечисленные факторы способствовали увеличению риска развития ИМ у женщин с сохраненной менструальной функцией в нашем исследовании. Обращает внимание более чем в 2 раза чаще встречаемая патология щитовидной железы в группе женщин в постменопаузе, что можно объяснить большими инволюционными изменения в этой группе и соответствует данным литературы об увеличении частоты тиреопатий с возрастом [19,20]. Однако считать данные изменения дополнительным триггером в развитии ИМ в этой группе пациенток, по-видимому, преждевременно, учитывая очень невысокую частоту изменений уровня гормонов щитовидной железы (гипер-или гипофункция наблюдалась всего у 5,0 % пациенток из 1-й группы и 8,2 % из 2-й группы).…”