Serum Thyroxine and Triiodothyronine Concentrations in Rats Receiving Lithium Carbonate

Dhawan, D. K.; Sharma, Reetika; Sharma, Ravindra; Rj, Dash

doi:10.1055/s-2007-1013465

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…The results of the zinc1lithium-treated group have also been compared with the results of the lithium-fed group. In the present study, the serum lithium levels were in the therapeutic range of 0.4-0.9 mEq/L, following the similar dose (26,27).…”

Section: Observationssupporting

confidence: 58%

Zinc modulates lithium‐induced hepatotoxicity in rats

Chadha

Bhalla

Dhawan

2008

Liver International

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Section: Observationssupporting

confidence: 58%

Zinc modulates lithium‐induced hepatotoxicity in rats

Chadha

Bhalla

Dhawan

2008

Liver International

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“…Animals of group II and IV were given lithium in the form of lithium carbonate in their diet at a dose of 1.1 g/Kg diet (Dhawan et al, 1985). Animals of group III and IV were given zinc in the form of zinc sulfate mixed in drinking water at a dose level of 227 mg/L.…”

Section: Methodsmentioning

confidence: 99%

“…It is easily absorbed from gut, distributed readily throughout the body, and excreted almost entirely by the kidneys (Rosenthal and Goodwim, 1982;Dhawan et al, 1987 b). Serum lithium levels were found to be in the therapeutic range of 0.5-1.2 mEq/l following the administration of lithium carbonate to rats at a dose of 1.1 g/Kg diet (Dhawan et al, 1999;Dhawan et al, 1985). Lithium is one of the few cations that are tolerated in concentrations upto and above 1 mmole/Kg.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Zinc in Modulating Lithium Induced Biochemical and Behavioral Changes in Rat Brain

2007

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1. The purpose of the present study was to determine the effect of zinc on the status of various neurotransmitters as well as behavioral patterns of lithium-treated rats. The study was designed with a view to find out whether zinc affords protection to brain against lithium toxicity. 2. Animals were segregated into four different groups. Animals in group I were fed with standard laboratory feed and water ad libitum and served as normal controls. Animals in group II and IV were given lithium in the form of lithium carbonate in their diet at a dose level of 1.1 g/Kg diet. Animals in group III and IV were given zinc treatment in the form of zinc sulfate at a dose level of 227 mg/L mixed in drinking water of animals. 3. The effects of all the treatments were studied for a duration of 1, 2, and 4 months with regard to the parameters, which included estimation of serotonin and dopamine concentrations as well as the activity of acetylcholinesterase in cerebral cortex of rat brain. Further, passive avoidance, active avoidance, and behavior despair tests were conducted to assess the short-term memory, cognitive behavior, and psychomotor dysfunction of the animals, respectively. 4. Initially, a decrease in the acetylcholinesterase activity was reported in cerebral cortex followed by an increase in the enzyme activity after 2 and 4 months of lithium treatment. Serotonin concentration significantly decreased after 2 and 4 months of lithium treatment, whereas dopamine concentration increased significantly after 4 months of lithium treatment. Zinc administration to the lithium-treated group significantly improved the acetylcholinesterase activity as well as the concentration of dopamine and serotonin. Further, lithium-treated rats showed an increase in depression time as compared to normal controls both after 1 and 4 months of treatment. Short-term memory significantly improved in lithium-treated rats in all treatment groups. However, no change in the cognitive behavior of the animals was reported after lithium treatment. Zinc co-administration with lithium significantly improved the short-term memory and cognitive functions of the animals. From the above results it can be concluded that zinc proved beneficial in altering the status of neurotransmitters as well as the behavior patters of the animals treated with both short and long-term lithium therapy.

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Effect of lithium on hepatic drug-metabolizing enzymes of protein-deficient rats

Tandon

Nagpaul

Dhawan

1997

Biol Trace Elem Res

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Protein deficiency was produced by feeding synthetic 8%-protein diet. Lithium carbonate at the dose level of 1.1g/kg diet was administered to normal and protein-deficient rats for a period of one mo. A significant inhibition in the levels of cytochrome (cyt) P450, cyt b5, glutathione (GSH), glutathione S-transferase (GST) and glutathione peroxidase (GPx), but an increase in gamma-glutamyl transpeptidase (gamma-GT), was observed in low-protein LP-fed rats. Lithium treatment to normal rats caused no significant change in the activities of cyt P450, cyt b5, GST, and GSH levels, whereas there was elevation in the activities of gamma-GT and GPx and suppression in glutathione reductase (GRd) activity. Lithium administration to LP-fed rats resulted in significant increases in the hepatic gamma-GT and GPx activities.

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Serum Thyroxine and Triiodothyronine Concentrations in Rats Receiving Lithium Carbonate

Cited by 8 publications

References 8 publications

Zinc modulates lithium‐induced hepatotoxicity in rats

Zinc modulates lithium‐induced hepatotoxicity in rats

Effectiveness of Zinc in Modulating Lithium Induced Biochemical and Behavioral Changes in Rat Brain

Effect of lithium on hepatic drug-metabolizing enzymes of protein-deficient rats

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