Serum Total 25‐OH Vitamin D Adds Little Prognostic Value in Patients Undergoing Coronary Catheterization

Gerling, Michael E.; James, Matthew T.; Wilton, Stephen B.; Naugler, Christopher; Southern, Danielle; Galbraith, P. Diane; Knudtson, Merril L.; Koning, Lawrence de

doi:10.1161/jaha.116.004289

Cited by 8 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, no association between vitamin D and mortality was found in a prospective study of older men (32) . Similarly, Gerling et al (33) found that serum total 25-OH vitamin D was inversely associated with mortality risk, and this association was attenuated by several competing risk factors. They suggested that overall 25-OH vitamin D added little prognostic value over established risk factors.…”

Section: Discussionmentioning

confidence: 89%

“…Vitamin D may attenuate the adverse effects (including increased NFκB expression) of advanced glycation end-products on endothelial cells (42) . A previous study demonstrated that 25(OH)D downregulated tissue factor and up-regulated thrombomodulin expression in cultured monocytic cells via a VDR-mediated mechanism (33) . Last, parathyroid hormone is elevated in patients with VDD.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Impact of serum 25-hydroxyvitamin D on cardiac prognosis in Chinese patients with heart failure

2019

View full text Add to dashboard Cite

There is growing evidence that suggests the association of vitamin D status with the development and progression of heart failure (HF). The objective of the present study is to assess the impact of concentration of serum 25-hydroxyvitamin D (25(OH)D) on cardiac prognosis in patients with HF. Between 1 January 2015 and 31 December 2016, we consecutively recruited patients with HF. Patients were followed prospectively for a median duration of 1 year. Serum concentration of 25(OH)D was measured with competitive chemiluminescent immunoassay. The endpoints were cardiac events, including CVD death and rehospitalisation for worsening HF. Univariate and multivariable adjustments were performed with Cox proportional-hazard regression analyses. The 25(OH)D concentration was obtained in 343 patients with a median value of 17·4 (interquartile range 12·6–23·4) ng/ml. There were 102 cardiac events, including forty-three deaths and fifty-nine rehospitalisations. Multivariate Cox hazard analysis found that the serum concentration 25(OH)D was independently associated with cardiac events (hazard ratio 0·93, 95 % CI 0·88, 0·97) and CVD mortality (hazard ratio 0·83; 95 % CI 0·77, 0·89) after adjustment for confounding factors. We divided the HF patients into four groups according to the 25(OH)D quartiles. Kaplan–Meier analysis found that the patients with lower serum 25(OH)D concentration had a higher risk of cardiac events or CVD mortality than those with high serum 25(OH)D concentration (log-rank test P < 0·001 and P = 0·032). Decreased serum concentrations of 25(OH)D were associated with cardiac prognosis and CVD mortality in a Chinese population with HF independent of other baseline HF markers.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Impact of serum 25-hydroxyvitamin D on cardiac prognosis in Chinese patients with heart failure

2019

View full text Add to dashboard Cite

show abstract

“…Researchers found that addition of serum 25(OH)D to the Framingham Risk Score could improve coronary heart disease risk estimation in patients with essential hypertension [25] . However, considering 25(OH)D in addition to established risk factors only marginally added prognostic value of mortality risk in patients undergoing coronary catheterization [26] .…”

Section: Discussionmentioning

confidence: 99%

Association of Serum 25(OH)D Levels with Incident Type 2 Diabetes in Chinese adults: A Prospective Cohort Study

Hu¹,

Zhi²,

Wang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Although many cross-sectional studies that have examined the relationship of Serum 25-hydroxyvitamin D [25(OH)D] levels with incident type 2 diabetes (T2D), there are very few reports for cohort studies. Here, we performed an a prospective cohort study to investigate the effect modification of traditional risk factors on association of serum 25(OH)D with T2D and to determine if addition of serum 25(OH)D improve the risk prediction of T2D. A total of 1926 adults without diabetes were prospectively followed for 36 months in China. During a mean of 36 months of follow-up, 114 participants (5.9%) developed incident T2D. Although no significant relationship was found in total population, stratified analyses indicated that low 25(OH)D levels was associated with increased T2D risk among individuals who were male, overweight/obese, with insufficient physical activity, or normal fasting plasma glucose at baseline. Additive interaction analysis showed that low 25(OH)D levels and insufficient physical activity interacts to increase the risk of T2D (RERI = 0.875, 95% CI: 0.204–1.545). Addition of low serum 25(OH)D significantly improved the predictive performance of T2D beyond conventional risk factors (NRI = 0.205, 95% CI:0.019–0.391). Our results suggest that low serum 25(OH)D and insufficient physical activity interact synergistically to influence the risk of T2D in Chinese adult population. Adding serum 25(OH)D to conventional risk factors improves the risk prediction of T2D.

show abstract

“…Researchers found that the addition of serum 25(OH)D to the Framingham Risk Score could improve coronary heart disease risk estimation in patients with essential hypertension or patients with T2D ( 22 , 23 ). However, adding serum 25(OH)D in addition to established risk factors only marginally added prognostic value of mortality risk in patients undergoing coronary catheterization ( 49 ). Considering that vitamin D deficiency and insufficiency are easy to be diagnosed and cured, future studies are needed to evaluate the cost-benefit of adding serum 25(OH)D into the T2D risk estimation and then determine the feasibility of measuring serum 25(OH)D for T2D prevention, especially in high-risk populations.…”

Section: Discussionmentioning

confidence: 99%

The modification of individual factors on association between serum 25(OH)D and incident type 2 diabetes: Results from a prospective cohort study

Zhi

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

Several epidemiological studies have suggested an association between low vitamin D status and increased risk for type 2 diabetes (T2D). This study aimed to explore the dose-response relationship of serum 25-hydroxyvitamin D [25(OH)D] concentrations with incident T2D and the interaction between serum 25(OH)D with individual factors on T2D risk. A total of 1,926 adults without diabetes (mean age: 52.08 ± 13.82 years; 42% men) were prospectively followed for 36 months. Cox proportional hazards model and restricted cubic spline analysis were performed to assess the association and dose-response relationship between serum 25(OH)D and T2D incidence. Both additive and multiplicative interactions were calculated between serum 25(OH)D and individual factors. The net reclassification index (NRI) was used to evaluate the improvement of risk prediction of T2D by adding serum 25(OH)D to traditional risk factors. There were 114 new T2D cases over a mean follow-up of 36 months. Serum 25(OH)D was not associated with T2D incidence, and no significant dose-response relationship was found in the total population. However, stratified analyses suggested a non-linear inverse relationship among individuals with baseline fasting plasma glucose (FPG) <5.6 mmol/L (Poverall = 0.061, Pnon–linear = 0.048). And a significant multiplicative interaction was observed between serum 25(OH)D and FPG on T2D risk (P = 0.005). In addition, we found a significant additive interaction of low serum 25(OH)D with older age (RERI = 0.897, 95% CI: 0.080–1.714; AP = 0.468, 95% CI: 0.054–0.881), male (AP = 0.441, 95% CI: 0.010–0.871), and insufficient physical activity (RERI = 0.875, 95% CI: 0.204–1.545; AP = 0.575, 95% CI: 0.039–1.111) on T2D risk. Significant additive interactions were also observed between vitamin D deficiency/insufficiency with male, overweight/obesity, and insufficient physical activity on T2D risk. Moreover, adding low serum 25(OH)D to a model containing established risk factors yielded significant improvements in the risk reclassification of T2D (NRI = 0.205, 95% CI: 0.019–0.391). Our results indicated a non-linear relationship of serum 25(OH)D concentrations with T2D risk among individuals with normal FPG and additive interactions of serum 25(OH)D with gender, overweight/obesity, and physical activity on T2D risk, suggesting the importance of outdoor exercise.

show abstract

Serum Total 25‐OH Vitamin D Adds Little Prognostic Value in Patients Undergoing Coronary Catheterization

Cited by 8 publications

References 32 publications

Impact of serum 25-hydroxyvitamin D on cardiac prognosis in Chinese patients with heart failure

Impact of serum 25-hydroxyvitamin D on cardiac prognosis in Chinese patients with heart failure

Association of Serum 25(OH)D Levels with Incident Type 2 Diabetes in Chinese adults: A Prospective Cohort Study

The modification of individual factors on association between serum 25(OH)D and incident type 2 diabetes: Results from a prospective cohort study

Contact Info

Product

Resources

About