Serum Total and Lipid-Bound Sialic Acid Levels Following Acute Myocardial Infarction

Abstract

Although serum total sialic acid has been shown to be a cardiovascular risk factor, with elevated levels associated with increased cardiovascular mortality and also with cerebrovascular disease, the reason for the elevation in serum sialic acid content remains obscure. It has been shown that an increased output of serum proteins by the liver due to some type of acute phase reaction may be one of the possible sources of an increased serum sialic acid concentration in patients with myocardial infarction. An increase in the activity of sialidase, which cleaves the terminal sialic acid residues from oligosaccharides, glycoproteins and gangliosides, may also play an important role in the elevation of serum total sialic acid in myocardial infarction. Elevated serum total sialic acid in the blood might result either from the shedding or secreting of sialic acid from the cell membrane surface, or releasing of cellular sialic acid from the cell into the bloodstream due to cell damage after myocardial infarction. The purpose of the present study is to investigate serum total and lipid-bound sialic acid and the enzymes serum lactate dehydrogenase, creatine kinase and aspartate aminotransferase in patients with acute myocardial infarction, at 24 h post-infarction (day 1), 48 h post-infarction (day 2) and 72 h post-infarction (day 3). A possible role of cell damage in the elevation of serum total and lipid-bound sialic acid levels in these patients was also evaluated. In this study, 40 patients with myocardial infarction ranging in age from 42 to 68 years, and 26 healthy volunteers ranging in age from 45 to 71 years were included. Serum total sialic acid determination was carried out by the thiobarbituric acid method of Warren and lipid-bound sialic acfd by the method of Katopodis. Our data shows that a) there is a gradual increase in the levels of serum total sialic acid and lipid-bound sialic acid during the first three days after the acute myocardial infarction and b) the elevation in serum total sialic acid levels correlates with the elevation in lactate dehydrogenase activity only on day 1 following infarction. Therefore, either the shedding or secreting of sialic acid from the cell or cell membrane surface may be partly responsible for an increased serum sialic acid concentration especially on day 1 following myocardial infarction.

Laminektomi Yapılan Tavşanlarda Alfa-lipoik Asit Uygulamalarının Total Antioksidan Kapasite, Total Oksidan Kapasite, Paraoksonaz ve Total Sialik Asit Düzeyleri Üzerine Etkilerinin Araştırılması

“…It has been reported that SA concentration rapidly increases during the pathological circumstances since tissue destruction and proliferation ocur [17] . We propose that, in accordance with the reports published by other investigators previously [18] , these changes in SA levels originate from the over secretion of the lipid-bounded sialic acid compounds exerted by the sialoprotein synthesis in the liver [18] and increased sialidase enzyme activity [35] during the inflammation [36] .…”

Sialic Acid or Troponin T to Detect Perioperative Myocardial Damage in Patients Undergoing Elective Coronary Artery Bypass Grafting.

“…22 An elevated concentration of serum total SA in the blood might result either from the shedding or secreting of SA from the cell membrane surface, or release of cellular SA from the cell into the bloodstream because of cell damage after myocardial injury. 4,7,23 It is known that a lot of ischemic changes occur during CABG, and the serum concentration of SA during CABG may contribute significantly to this ischemic process. In the samples taken from the artery and coronary sinus at 1 min after unclamping of aorta, early ischemic changes of CABG were seen.…”

Serum Sialic Acid Levels in Individuals with or without Iron Deficiency Anemia

“…Çeşit-li çalışmalarda tümör hücresinden veya miyokard hasarı sonrasında miyokard hücresinden dolaşıma sialik asidin salındığı bildirilmiştir (18,19). Hücre membranından SA kalıntılarının ayrılmasında, glikoprotein ve glikolipitlerden terminal SA kalıntılarının uzaklaştırılma-sını katalizleyen sialidaz rol oynar.…”