Serum total antioxidant capacity and enzymatic defence of dogs with chronic heart failure and atrial fibrillation: a preliminary study

Michałek, Marcin; Tabiś, Aleksandra; Noszczyk-Nowak, Agnieszka

doi:10.2478/jvetres-2020-0047

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…53 In the same way, the study by Michałek et al reported that serum CuZn-SOD activity and serum total antioxidant capacity were significantly lower in their study groups compared to in control animals; specifically, they found that catalase activity was significantly higher and plasma GPx activity was significantly lower in dogs with chronic heart failure and AF compared to those with chronic heart failure only, sinus rhythm, or control dogs. 54…”

Section: Superoxide Dismutase and Catalasementioning

confidence: 99%

The Role of Major Biomarkers of Stress in Atrial Fibrillation: A Literature Review

Rafaqat¹,

Rafaqat²

2023

J Innov Cardiac Rhythm Manage.

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Numerous studies have reported that physical or emotional stress can provoke atrial fibrillation (AF) or vice versa, which suggests a potential link between exposure to external stressors and AF. This review article sought to describe in detail the relationship between major stress biomarkers and the pathogenesis of AF and presents up-to-date knowledge on the role of physiological and psychological stress in AF patients. For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF. A previous study has investigated the association between increased copeptin levels and paroxysmal AF (PAF) in rheumatic mitral stenosis and reported that copeptin concentration was not independently associated with AF duration. Reduced levels of chromogranin were measured in patients with AF. Furthermore, the dynamic activity of antioxidant enzymes, including catalase as well as superoxide dismutase, was examined in PAF patients during a period of <48 h. Malondialdehyde activity, serum high-sensitivity C-reactive protein, and high mobility group box 1 protein concentrations were significantly greater in patients with persistent AF or PAF compared to controls. Pooled data from 13 studies confirmed a significant reduction in the risk of AF related to the administration of vasopressin. Other studies have revealed the mechanism of action of heat shock proteins (HSPs) in preventing AF and also discussed the therapeutic potential of HSP-inducing compounds in clinical AF. More research is required to detect other biomarkers of stress, which have not been reported in the pathogenesis of AF. Further studies are required to identify their mechanism of action and drugs to manage these biomarkers of stress in AF patients, which might help to reduce the prevalence of AF globally.

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Section: Superoxide Dismutase and Catalasementioning

confidence: 99%

The Role of Major Biomarkers of Stress in Atrial Fibrillation: A Literature Review

Rafaqat¹,

Rafaqat²

2023

J Innov Cardiac Rhythm Manage.

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“…Members of the nonenzymatic antioxidants are, e.g.,: ascorbic acid, alpha-tocopherol, uric acid (UA) or glutathione (GSH). Oxidative stress biomarkers such as the activity of antioxidant enzymes and total antioxidant capacity or ROS concentration can correlate with the occurrence of arrhythmias (Türker et al, 2016;Yang et al, 2018;Adameova et al, 2020;Michałek et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Redox imbalance in patients with heart failure and ICD/CRT-D intervention. Can it be an underappreciated and overlooked arrhythmogenic factor? A first preliminary clinical study

Szyller,

Antoniak,

Wadowska

et al. 2023

Front. Physiol.

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Introduction: Redox imbalance and oxidative stress are involved in the pathogenesis of arrhythmias. They also play a significant role in pathogenesis of heart failure (HF). In patients with HFand implanted cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D), the direct current shocks may be responsible for additional redox disturbances and additionally increase arrhythmia risk. However, the precise role of oxidative stress in potentially fatal arrhythmias and shock induction remains unclear.Methods: 36 patients with diagnosed HF and implanted ICD/CRT-D were included in this study. Patients were qualified to the study group in case of registered ventricular arrhythmia and adequate ICD/CRT-D intervention. The control group consisted of patients without arrhythmia with elective replacement indicator (ERI) status. Activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) in erythrocyte (RBC), SOD, GPx activity and reactive oxygen/nitrogen species (ROS/RNS) concentration in plasma were determined. The values were correlated with glucose, TSH, uric acid, Mg and ion concentrations.Results: In the perishock period, we found a significant decrease in RBC and extracellular (EC) SOD and RBC CAT activity (p = 0.0110, p = 0.0055 and p = 0.0002, respectively). EC GPx activity was also lower (p = 0.0313). In all patients, a decrease in the concentration of all forms of glutathione was observed compared to the ERI group. Important association between ROS/RNS and GSH, Mg, TSH and uric acid was shown. A relationship between the activity of GSH and antioxidant enzymes was found. Furthermore, an association between oxidative stress and ionic imbalance has also been demonstrated. The patients had an unchanged de Haan antioxidant ratio and glutathione redox potential.Conclusion: Here we show significant redox disturbances in patients with HF and ICD/CRT-D interventions. Oxidative stress may be an additional risk factor for the development of arrhythmia in patients with HF. The detailed role of oxidative stress in ventricular arrhythmias requires further research already undertaken by our team.

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Serum total antioxidant status in dogs: Reference intervals and influence of multiple biological and analytical factors

Perez‐Montero,

Fermin‐Rodriguez,

Portero‐Fuentes

et al. 2024

Veterinary Clinical Pathol

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BackgroundTotal antioxidant status (TAS) is one of the most widely used oxidative stress biomarkers, but the lack of canine RI and the influence of analytical factors hinder its application in clinical practice.ObjectivesThe aims of this study were to establish canine assay‐specific RI for TAS and evaluate the sources of biological variation and the association between TAS and multiple hematologic and biochemical variables.MethodsBlood samples from 190 clinically healthy dogs were collected, encompassing pet dogs (82), police dogs (56), and shelter dogs (52). After hematologic and biochemical analysis, serum TAS was determined by means of a commercial 2,2′‐azinobis (3‐ethylbenzthiazolin‐6‐sulfonic acid) (ABTS) test. The American Society for Veterinary Clinical Pathology guidelines were followed to establish the RI, employing nonparametric methods. Univariate analysis and multivariate analysis were conducted to assess the influence of biological and analytical variables, yielding a final regression model.ResultsThe final reference population comprised 143 dogs, for which the RI was established (1.41–2.27 mmol/L). Partitioning was applied to the three study groups. The regression model revealed that police dogs had significantly higher TAS values than pet dogs. Furthermore, significant associations between four biochemical variables (albumin, globulins, cholesterol, and aspartate aminotransferase) and serum TAS were found.ConclusionsThis is the first study to establish RI for serum TAS in a large and heterogeneous canine population and provide data on its relationship with analytical variables. These findings could potentially improve the interpretation of TAS in clinical environments.

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Serum total antioxidant capacity and enzymatic defence of dogs with chronic heart failure and atrial fibrillation: a preliminary study

Cited by 5 publications

References 31 publications

The Role of Major Biomarkers of Stress in Atrial Fibrillation: A Literature Review

The Role of Major Biomarkers of Stress in Atrial Fibrillation: A Literature Review

Redox imbalance in patients with heart failure and ICD/CRT-D intervention. Can it be an underappreciated and overlooked arrhythmogenic factor? A first preliminary clinical study

Serum total antioxidant status in dogs: Reference intervals and influence of multiple biological and analytical factors

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