Serum total immunoglobulin E levels in Canadian adults

Holford-Strevens, V.; Warren, Peter; Wong, Cindy J.; Manfreda, Jure

doi:10.1016/0091-6749(84)90363-4

Cited by 81 publications

(35 citation statements)

References 21 publications

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“…This finding confirms observations made in Tucson, USA [5] and in Greece [19], whereas it is in contrast with other studies [4,20,26]. Recently, JARVIS et al [8] have found, in a stratified random sample of 20-44 yr old subjects living in East Anglia, that, among nonsmokers, geometric mean total IgE was higher in males than females.…”

Section: Discussionsupporting

confidence: 83%

“…Sex [5,19,20] and age [5] are related to IgE levels, but their effects are not homogeneous in epidemiological surveys. In some studies the IgE levels are higher in males than in females [5,19] and are lower during adult life [5], whereas in others there is no sex [4,20] or age effect [4,19,20].…”

mentioning

confidence: 99%

“…In some studies the IgE levels are higher in males than in females [5,19] and are lower during adult life [5], whereas in others there is no sex [4,20] or age effect [4,19,20]. Further, an association of total serum IgE with specific serum IgE has been described [3].…”

mentioning

confidence: 99%

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The Po River Delta Respiratory Epidemiological Survey: an analysis of factors related to level of total serum IgE

Sapigni¹,

Biavati²,

Simoni³

et al. 1998

Eur Respir J

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The purpose of the present study was to analyse whether sex, age, skin test reactivity, cigarette smoking and occupational exposure were related to the total serum immunoglobulin (Ig)E concentrations (kU x L[-1]), in a general population sample. We studied 1,905 subjects (915 males, 990 females) of a general population sample (n=2,841, 8-73 yrs) participating in the second cross-sectional respiratory epidemiological survey in the rural Po Delta area (near Venice, North Italy). Distribution of total serum IgE concentrations was skewed, thus a log-transformation was performed to obtain a Gaussian shape. Significantly higher values of IgE were found in males compared to females. In general, a peak of IgE concentration was found at 8-14 yrs. IgE values tended to be lower in older than younger adults. Significantly higher serum IgE levels were shown in subjects with a positive skin-prick test index (ST+) than in those with a negative skin-prick test index (ST-). There was a significant relationship of total IgE levels with skin reactivity to pollens and house-dust mites. In both sexes higher values of IgE were found in current smokers than in ex-nonsmokers, regardless of skin-test reactivity. There was no significant difference in IgE values between ex- and nonsmokers. Passive smoking and occupational exposure were significantly related to increased IgE values. Our results confirm that in a general population sample immunoglobulin E concentrations are related not only to skin-prick test reactivity to common aeroallergens, but also to other risk factors for chronic obstructive lung diseases, such as sex, active/ passive smoking and occupational exposure.

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Section: Discussionsupporting

confidence: 83%

mentioning

confidence: 99%

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The Po River Delta Respiratory Epidemiological Survey: an analysis of factors related to level of total serum IgE

Sapigni¹,

Biavati²,

Simoni³

et al. 1998

Eur Respir J

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“…Although the values of total IgE were transformed to logarithmic scale (log IgE), the antilog values of the mean log IgE (i.e., the geometric mean) are reported (27).…”

Section: Discussionmentioning

confidence: 99%

“…The method for obtaining allergen from grain and grain storage mite was described in an earlier paper (26,27). All other commercially available preparations in single batches were supplied by Hollister-Stier Laboratories, Mississauga, Ontario.…”

Section: Skin Testingmentioning

confidence: 99%

Acute Symptoms Following Exposure to Grain Dust in Farming

Manfreda¹,

Holford-Strevens²,

Cheang³

et al. 1986

Environmental Health Perspectives

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History of acute symptoms (cough, wheezing, shortness of breath, fever, stuffy nose, and skin itching/ rash) following exposure to grain dust was obtained from 661 male and 535 female current and former farmers. These symptoms were relatively common: 60% of male and 25% of female farmers reported at least one such symptom on exposure to grain dust. Association of cough, wheezing, shortness of breath, and stuffy nose with skin reactivity and capacity to form IgE is consistent with an allergic nature of these symptoms. Barley and oats dust were perceived as dust most often producing symptoms. On the other hand, grain fever showed a different pattern, i.e., it was not associated with either skin reactivity or total IgE. Smoking might modify the susceptibility to react to grain dust with symptoms. Only those who reported wheezing on exposure to grain dust may have an increased risk to develop chronic airflow obstruction.

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Life history, immune function, and intestinal helminths: Trade‐offs among immunoglobulin E, C‐reactive protein, and growth in an Amazonian population

Blackwell

Snodgrass

Madimenos

et al. 2010

American J Hum Biol

114

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Objectives Infection with helminths is associated with shifts in host immunity, including increased production of immunoglobulin E (IgE) and reduced inflammation. Given limited energy budgets, these shifts may involve changes in energy allocation toward competing demands. Here we test for potential trade-offs between growth, IgE, and the inflammatory marker C-reactive protein (CRP). Methods Dried blood spots and anthropometrics were collected from 162 Shuar forager-horticulturalists from a village in southeastern Ecuador. Enzyme-linked immunosorbent assays (ELISAs) were used to measure IgE and CRP. Relationships among IgE, CRP, and anthropometrics were examined in three groups: children aged 2–7 years (n = 63), children aged 8–15 (n = 61), and adults over age 18 (n = 37). Results Geometric mean IgE was 1,196 IU ml−1 while geometric mean CRP was 1.33 mg l−1. In children, IgE and CRP were negatively correlated (r = −0.21, P = 0.02, df = 122). Controlling for fat stores and age, IgE was associated with lower stature in children (t = −2.04, P = 0.04, df = 109), and adults (t = −3.29, P < 0.01, df = 33). In children there was a significant interaction between age and CRP, such that in younger children CRP was associated with shorter stature, but in older children was associated with greater stature (t = 2.15, P = 0.04, df = 109). Conclusions These results suggest that infection with helminths may have hidden costs associated with immunological changes, and that these costs may ultimately affect growth and other life history parameters.

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Serum total immunoglobulin E levels in Canadian adults

Cited by 81 publications

References 21 publications

The Po River Delta Respiratory Epidemiological Survey: an analysis of factors related to level of total serum IgE

The Po River Delta Respiratory Epidemiological Survey: an analysis of factors related to level of total serum IgE

Acute Symptoms Following Exposure to Grain Dust in Farming

Life history, immune function, and intestinal helminths: Trade‐offs among immunoglobulin E, C‐reactive protein, and growth in an Amazonian population

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