Serum Trace Element Levels in Febrile Convulsion

Amiri, Mojtaba; Farzin, Leila; Moassesi, Mohammad Esmail; Sajadi, Fattaneh

doi:10.1007/s12011-009-8487-6

Cited by 54 publications

(61 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The changes in bio-elements in FS explained the respond of the metabolism. Amiri et al found signifi cantly low levels of Se and Zn in patients with FS (21).…”

Section: Discussionmentioning

confidence: 98%

Major and minor bio-element status in children with febrile seizure

Akbayram¹,

Cemek²,

Büyükben³

et al. 2012

BLL

View full text Add to dashboard Cite

Febrile seizures (FS) are the most common cause of seizures in children. The exact etiopathogenesis is unknown but involves factors like genetic predisposition and alterations in the levels of neurotransmitters and some trace elements. The study includes 48 consecutive children with FS, and 55 healthy age matched control subjects. Calcium, magnesium and potassium concentrations in the febrile study group were lower than in the control group (p<0.05). Iron and Gallium levels in the study group were lower than in the control group (p<0.01). Serum Selenium (p<0.001), Zinc (p<0.001) and Strontium (p<0.05) levels were signifi cantly decreased in the study group when compared to the control group. There was no signifi cant difference between the control and study groups in Serum Barium, Beryllium and Copper levels (p>0.05). The aim of the present prospective analytical case-control study was to determine whether there was any change in element levels in children with FS (Ref. 33). Full Text in PDF www.elis.sk.

show abstract

“…The changes in bio-elements in FS explained the respond of the metabolism. Amiri et al found signifi cantly low levels of Se and Zn in patients with FS (21).…”

Section: Discussionmentioning

confidence: 98%

Major and minor bio-element status in children with febrile seizure

Akbayram¹,

Cemek²,

Büyükben³

et al. 2012

BLL

View full text Add to dashboard Cite

show abstract

“…The findings are consistent with some previous studies. 5,[9][10][11][12][13]19,20 Hypozincemia in present study was found to be more prevalent in children with simple febrile seizures compared to the control group. However, no classical clinical manifestations of hypozincemia like diarrhoea, impaired appetite, decreased growth velocity, acroorificial skin lesions, delayed wound healing, dysguesia and hypoguesia were present in these patients, demonstrating purely biochemical hypozincemia.…”

Section: Discussionmentioning

confidence: 64%

“…4,5 Zinc has an important role in various processes at the cellular level. It is involved in cellular growth and differentiation, is an important cofactor in various enzymatic activities taking place in different organs, proteins and cellular metabolism.…”

Section: Introductionmentioning

confidence: 99%

Relationship between serum zinc levels and simple febrile seizures: hospital based case control study

Hubaira¹,

Wani²,

Qadri³

2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Owing to the excessive susceptibility of the immature brain to temperature, febrile seizures remain one of the common neurological conditions of childhood. Although simple febrile seizures do not pose any increased neurological problems in adult life, but the anxiety, hospitalization and prophylaxis for the episode do call for a genuine concern. A correlation between zinc deficiency and febrile seizures has been proposed and a few studies undertaken have shown mixed conclusions. This case control study was undertaken to compare the serum Zinc levels in patients with simple febrile seizures against the controlled patients with short febrile illness without seizures and to find the correlation if any between simple febrile seizures and serum zinc levels.Methods: The hospital based, observational case control study was done in Batra Hospital and Medical research Centre, New Delhi. A total of 200 children aged 6 months to 6 years admitted in the hospital with history of short pyrexia (fever for 2 days or less) and fulfilling our inclusion criteria were enrolled for the study after taking an informed consent from their attendants and classified into 2 groups of 100 each as cases and controls. Patients with history of simple febrile seizures as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. The data was analysed on SPSS 17.Results: Our results showed a mean of serum zinc levels in cases as 61.53±15.87 mcg/dl which was found to be lower compared to controls as 71.90+18.50 mcg /dl. Further the difference was found to be statistically significant (P<0.05).Conclusions: Low serum zinc levels in the patients of simple febrile seizures in association with other risk factors may enhance the occurrence of seizures triggered by fever. Thus, a possible correlation exists between the mean serum zinc level and simple febrile seizures.

show abstract

“…3 Many studies have shown an association between low serum selenium levels and febrile seizures equally. [3][4][5] Some studies have shown no association. 6 Hence our study is an attempt to evaluate the association between the serum selenium level and febrile seizures.…”

Section: Introductionmentioning

confidence: 99%

Association between serum selenium levels and febrile seizures in Indian children: a case control study

Khadria

Jaidev

Vidya

2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Febrile seizures are the most common form of childhood seizures. Children are at particular risk for selenium deficiency. There was various hypothesis about the co-relation between selenium levels and febrile seizures. The aim of the present study was to determine whether there were any changes in serum selenium levels in children with febrile seizures when compared to children with febrile illness without seizures.Methods: This was a hospital based prospective case control study, consisting of 40 children (20 cases and 20 controls) aged between 6 months to 60 months. The serum selenium level was measured in each of them by atomic absorption spectrophotometer. Data was analysed by using frequency percentage and pearson’s chi square test.Results: Out of the 40 children included in the study, serum selenium level was lower in febrile seizure group (80%) when compared to controls (20%) which was statistically significant (P value: 0.003). Also, there was no statistically significant difference between males and females.Conclusions: In the present study, we found significantly low serum selenium levels in children with febrile seizures as compared to the children with febrile illness with no seizures. Decreased levels of selenium in children with febrile seizures may be the result of oxidative damage, occurring in the neuronal cells. In our study, a significant co-relation between low levels of selenium and febrile seizures have been observed in children. However, since the numbers are small, further studies with larger sample size are recommended.

show abstract

Serum Trace Element Levels in Febrile Convulsion

Cited by 54 publications

References 18 publications

Major and minor bio-element status in children with febrile seizure

Major and minor bio-element status in children with febrile seizure

Relationship between serum zinc levels and simple febrile seizures: hospital based case control study

Association between serum selenium levels and febrile seizures in Indian children: a case control study

Contact Info

Product

Resources

About