Serum Transaminase Concentrations and the Presence of Irritable Bowel Syndrome Are Associated with Serum 25-Hydroxy Vitamin D Concentrations in Adolescent Girls Who Are Overweight and Obese

Abstract

Background/Aims: Vitamin D deficiency has become endemic globally and its etiology is complex. Few studies have investigated the determinants of serum 25-hydroxy vitamin D (25-OH D). The aim of this study was to investigate the association between lifestyle patterns, liver functional tests (LFTs), and the presence of irritable bowel syndrome (IBS) with serum 25-OH D in apparently healthy girls. Methods: This cross-sectional study was undertaken in 965 adolescent girls aged 12–18 years. IBS was diagnosed using the Rome III questionnaire. An electrochemiluminescence method was used to measure serum 25-OH D. LFTs were measured using commercial kits and an auto analyzer. Linear regression and univariate analyses were performed to determine the association between continuous and categorical variables with serum 25-OH D respectively. Results: Serum 25-OH D was significantly higher in normal weight subjects compared to either overweight or obese subjects (9.5 ± 7.02 vs. 7.9 ± 5.7 ng/mL, p = 0.03). Physical activity level was positively associated with serum 25-OH D in overweight and obese subjects (β = 0.15, p < 0.05). An inverse relationship was found between the presence of IBS and 25-OH D in both normal (β = –1.95, p < 0.05), overweight and obese subjects (β = –1.83, p < 0.05). Serum alanine transaminase (ALT; β = –0.19, p < 0.05) and aspartate transaminase (β = –0.17, p < 0.05) were inversely associated with serum 25-OH in overweight and obese subjects. Conclusions: Individuals with IBS had significantly lower serum 25-OH D concentrations. In addition, there was an inverse association between serum ALT and 25-OH D. Prospective studies, and perhaps interventional trials, will be required to clarify these associations.

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks

“…This cross-sectional study was undertaken in adolescent female students aged between 12 and 19 years old in January 2015 (Bahrami et al, 2018; Khayyatzadeh et al, 2017). In brief, participants were recruited from six geographic areas in two cities from north-eastern Iran, Mashhad and Sabzevar, using a multi-stage cluster sampling way.…”

A Comprehensive Review of Transaminitis and Irritable Bowel Syndrome

“…By initial screening of the titles and abstracts, a further 237 articles were removed and 89 articles were filtered out for full-text screening. After reviewing the full text of these articles, a total of 83 studies were eliminated and, lastly, three studies (Lee et al, 2016, Fouad et al, 2010and Khayyatzadeh et al, 2017) were selected for this systematic review for quantitative and qualitative analysis. Figure 1 shows the utilization of the PRISMA 2009 flow diagram, demonstrating the process of screening these articles.…”

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High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea, and premenstrual syndrome in adolescents

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