Serum transferrin receptors: Distribution and diagnostic performance in pre-school children

Chouliaras, Giorgos; Premetis, Evangelos; Tsiftis, George; Drosatou, Panayiota; Papassotiriou, Ioannis; Stamoulakatou, Alexandra; Lycopoulou, Lilia

doi:10.1016/j.bcmd.2009.03.007

Cited by 11 publications

(10 citation statements)

References 32 publications

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“…Thus, several studies have found no sex differences for sTfR and sTfR-F index [21,[28][29][30], although others have reported a higher prevalence of ID and higher sTfR values in male infants and children [31,37]. In our study, the sTfR and sTfR-F index values were higher in males but the differences were slight; although statistically significant, they were not clinically relevant.…”

Section: Discussioncontrasting

confidence: 79%

“…Published sTfR and sTfR-F index data for healthy Downloaded by [RMIT University Library] at 05:48 10 March 2016 children have consistently reflected decreasing values with age [21,22,[29][30][31]. Corroborating these earlier findings, in our study the values of both parameters gradually decreased; although the changes observed were statistically significant, the variations for sTfR were very slight, and more marked for sTfR-F index ( Table 2).…”

Section: Discussionsupporting

confidence: 60%

“…Heterogeneous results have been reported, with differences in the measurement method used, the source of subjects (there are very few population-based studies), age range, and diagnostic criteria to define ID [21,22,25,[28][29][30][31] (most studies have used serum ferritin as the only marker of ID). Similarly few studies, besides iron parameters, include data about the degree of erythropoietic activity, another determinant factor of sTfR values, or data on adiposity, an individual condition that, like age and sex, can affect body iron status.…”

Section: Introductionmentioning

confidence: 97%

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Reference values of serum transferrin receptor (sTfR) and sTfR/log ferritin index in healthy children

Vázquez-López

López-Ruzafa

Lendínez-Molinos

et al. 2016

Pediatric Hematology and Oncology

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ABSTARCT The aims of this study were to determine appropriate reference ranges for serum transferrin receptor (sTfR) and sTfR/log ferritin (sTfR-F index) in healthy children and their relationship with iron parameters, erythropoiesis, and other conditions presented by the subject. A total of 902 children with normal iron status, aged 1-11 years, were included in a cross-sectional study. A physical examination was conducted and z-score of body mass index (zBMI) obtained. Complete blood count, iron biomarkers, erythropoietin, C-reactive protein, sTfR, and sTfR/log ferritin were determined. Linear multiple regression was applied to identify the factors that determined sTfR and sTfR-F index variability. Mean values for sTfR and sTfR-F index were 1.22 ± 0.28 mg/L (95% confidence interval [CI]: 1.2-1.23) and 0.87 ± 0.25 (95% CI: 0.85-0.88). The reference intervals (2.5th to 97.5th percentiles [P2.5-P97.5]) were 0.78-1.9 mg/L and 0.49-1.46, respectively. sTfR and sTfR-F values decreased with age (P <.03 and P <.0001, respectively). No changes were observed with sex. Changes in sTfR and sTfR-F index were consistent with ferritin and erythropoietin variations. Iron biomarkers, erythropoietin, and zBMI predicted 19% and 18.1% of the sTfR and sTfR-F index variability. The results provide reference ranges for sTfR and sTfR-F index in healthy children for clinical use in the assessment of body iron status. Both biomarkers are predicted by iron parameters, erythropoietin, and zBMI.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 97%

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Reference values of serum transferrin receptor (sTfR) and sTfR/log ferritin index in healthy children

Vázquez-López

López-Ruzafa

Lendínez-Molinos

et al. 2016

Pediatric Hematology and Oncology

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“…In our study, age and gender factors were not statistically significant, which is in agreement with the literature. In defining the correct diagnosis for IDA, one study affirmed that measuring sTfR and ferritin levels together was more valuable than measurement of sTfR levels alone [13]. Similar studies reported that the accuracy of sTfR and sTfR/ SF (serum ferritin) rates and the Log (sTfR/SF) to reflect iron deficiency were as high as 83% and 99%, respectively [14].…”

Section: Discussionmentioning

confidence: 61%

The Significance of Serum Transferrin Receptor Levels in the Diagnosis of the Coexistence of Anemia of Chronic Disease and Iron Deficiency Anemia

Yokuş¹,

Yılmaz²,

Albayrak³

et al. 2011

EAJM

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Objective: Iron defi ciency anemia is the most common cause of microcytic anemia throughout the world. Ferritin levels are good indicators of iron stores; however, levels may increase irrespective of iron stores in cases of chronic disease. Therefore, it is diffi cult to diagnose iron defi ciency anemia coexisting with anemia of chronic disease. Materials and Methods:To determine the level of transferrin receptor in subjects, 30 patients with iron defi ciency anemia, 30 patients with anemia of chronic disease and 30 patients with both diseases were included in the study. Results:Mean serum transferrin receptor levels were 5.99±2.98 mg/L in the iron defi ciency anemia group, 1.90±1.15 mg/L in the anemia of chronic disease group and 3.07±0.90 mg/L in the combination group. Comparing groups with each other revealed signifi cant diff erences (p<0.05). Conclusion:It is concluded that the assessment of serum transferrin receptor levels is a useful method for the diagnosis of iron defi ciency anemia in patients.Key Words: Anemia of chronic disease, Iron defi ciency anemia, Serum transferrin receptor level Özet Amaç: Demir eksikliği anemisi tüm dünyada en sık görülen mikrositer anemi sebebidir. Ferritin düzeyi demir depolarının iyi bir göster-gesi olmasına rağmen kronik hastalık durumlarında demir depoların-dan bağımsız olarak yükselebilmektedir. Bu yüzden kronik hastalık anemisiyle birlikte olan demir eksikliği anemisinin tanısını koymak zordur. Gereç ve Yöntem:Transferrin reseptör düzeyinin yararını değerlen-dirmek amacıyla demir eksikliği anemisi, kronik hastalık anemisi ve kombine olmak üzere her gruptan 30'ar hasta çalışmaya alındı. Bulgular:Ortalama serum transferrin reseptör düzeyleri demir eksikliği anemisinde 5.99±2.98 mg/L, kronik hastalık anemisinde 1.90±1.15 mg/L ve kombine olan grupta ise 3.07±0.90 mg/L olarak bulundu. Gruplar birbirleri ile karşılaştırıldığında aralarında anlamlı farklılık saptandı (p<0.05). Sonuç:Hastalarda demir eksikliği anemisini tespit etmede, serum transferrin reseptör düzeyinin değerlendirilmesinin oldukça faydalı bir yöntem olduğu sonucuna varılmıştır.

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“…Detailed description regarding enrolment, exclusion criteria and definition of groups has been published elsewhere [3]. In brief, informed consent was obtained from the parents of 521 children aged 1-6 years from eight day-care centres in Athens, blood samples were drawn and a panel of haematological and biochemical parameters was determined.…”

Section: Methodsmentioning

confidence: 99%

Age, beta thalassaemia trait, and iron-deficient anaemia significantly affect reticulocyte indices in pre-school children

et al. 2010

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Serum transferrin receptors: Distribution and diagnostic performance in pre-school children

Cited by 11 publications

References 32 publications

Reference values of serum transferrin receptor (sTfR) and sTfR/log ferritin index in healthy children

Reference values of serum transferrin receptor (sTfR) and sTfR/log ferritin index in healthy children

The Significance of Serum Transferrin Receptor Levels in the Diagnosis of the Coexistence of Anemia of Chronic Disease and Iron Deficiency Anemia

Age, beta thalassaemia trait, and iron-deficient anaemia significantly affect reticulocyte indices in pre-school children

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